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Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1–F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived endocrine disruptor compounds bisphenol-A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP) at two different doses promoted epigenetic transgenerational inheritance of adult onset disease and associated DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to either the “plastics” or “lower dose plastics” mixture during embryonic days 8 to 14 of gonadal sex determination and the incidence of adult onset disease was evaluated in F1 and F3 generation rats. There were significant increases in the incidence of total disease/abnormalities in F1 and F3 generation male and female animals from plastics lineages. Pubertal abnormalities, testis disease, obesity, and ovarian disease (primary ovarian insufficiency and polycystic ovaries) were increased in the F3 generation animals. Kidney and prostate disease were only observed in the direct fetally exposed F1 generation plastic lineage animals. Analysis of the plastics lineage F3 generation sperm epigenome previously identified 197 differential DNA methylation regions (DMR) in gene promoters, termed epimutations. A number of these transgenerational DMR form a unique direct connection gene network and have previously been shown to correlate with the pathologies identified. Observations demonstrate that a mixture of plastic derived compounds, BPA and phthalates, can promote epigenetic transgenerational inheritance of adult onset disease. The sperm DMR provide potential epigenetic biomarkers for transgenerational disease and/or ancestral environmental exposures.
Strength: a River cuts through a Rock not because of its Power but its Persistence
Exactly the struggles DES Daughters are experiencing in the UK
See more DES drugs photo set on flickr®
DES Activist and DES Daughter Caitlin McCarthy says:
” Lilly should just admit that DES has been shown to cause breast cancer and honor its promise to settle lawsuits. They’ve been saying this for more than a year now, and they haven’t done it. This is just going to get more embarrassing if they don’t. Lilly’s CEO needs to pull a Lance Armstrong, call Oprah Winfrey, and admit to the lies about DES ”
Read her post Maybe DES Will Finally Get its Day
It’s Time for Actions: did you SIGN THE PETITION ?
It also sounded too close to the history of DES (diethylstilbestrol)
Fertility clinics across the U.S. are prescribing a medication with a seriously concerning safety profile and no proven benefits
Will the lessons from the DES drug tragedy ever be learned? …
Read IVF on Steroids: The Dangerous Off-Label Use of ‘Dex’ During Pregnancy
theatlantic, JAN 16, 2013.
It is estimated that one in six women who were prescribed DES will develop breast cancer, whereas one in eight women in the general population will develop the disease
DES : a LifeTime Poisonous Ball and Chain to Carry…
Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…
How to reduce BPA levels by 60 percent in 3 days
BPA is a toxic chemical used in the lining of most food cans. Bisphenol-A is a synthetic estrogen like DES, linked to breast cancer, reproductive problems, obesity, ADHD, immune system harm and other serious health issues.
You can easily reduce your BPA exposure by avoiding consumption of canned foods that are acidic, salty or fatty, because BPA is more likely to leach from can linings into these kinds of foods.
Read How to reduce BPA levels by 60 percent in 3 days,
by breastcancerfund, March 29, 2011.