Poisoned by every Day Life: PLOS One Landmark Study

Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations

Chemicals found in every home may cause breast cancer, asthma, infertility and birth defects, global health chiefs said yesterday

Poisoned by every day life: Landmark study warns gender bending chemicals in your home, food and car ARE linked to a huge range of diseases  Read more: http://www.dailymail.co.uk/news/article-2281394/Poisoned-day-life-Landmark-study-warns-gender-bending-chemicals-home-food-car-ARE-linked-huge-range-diseases.html#ixzz2LfOpgG2J  Follow us: @MailOnline on Twitter | DailyMail on Facebook

  • Phthalates is used to soften plastic and improve consistency of cosmetics
  • Chemical commonly found in children’s toys, make up, cars and PVC flooring
  • Could cause breast cancer, asthma, infertility and birth defects, WHO says

Read Poisoned by every day life: Landmark study warns gender bending chemicals in your home, food and car ARE linked to a huge range of diseases.

PLOS One Study Abstract

Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1–F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived endocrine disruptor compounds bisphenol-A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP) at two different doses promoted epigenetic transgenerational inheritance of adult onset disease and associated DNA methylation epimutations in sperm. Gestating F0 generation females were exposed to either the “plastics” or “lower dose plastics” mixture during embryonic days 8 to 14 of gonadal sex determination and the incidence of adult onset disease was evaluated in F1 and F3 generation rats. There were significant increases in the incidence of total disease/abnormalities in F1 and F3 generation male and female animals from plastics lineages. Pubertal abnormalities, testis disease, obesity, and ovarian disease (primary ovarian insufficiency and polycystic ovaries) were increased in the F3 generation animals. Kidney and prostate disease were only observed in the direct fetally exposed F1 generation plastic lineage animals. Analysis of the plastics lineage F3 generation sperm epigenome previously identified 197 differential DNA methylation regions (DMR) in gene promoters, termed epimutations. A number of these transgenerational DMR form a unique direct connection gene network and have previously been shown to correlate with the pathologies identified. Observations demonstrate that a mixture of plastic derived compounds, BPA and phthalates, can promote epigenetic transgenerational inheritance of adult onset disease. The sperm DMR provide potential epigenetic biomarkers for transgenerational disease and/or ancestral environmental exposures.

Read Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations, PLOS one, January 24, 2013.

You Never know how STRONG you are until being STRONG is the Only Choice you have

Strength: a River cuts through a Rock not because of its Power but its Persistence

644382_564223063589915_1385702627_nDES victims have no other choice than being strong … A big THANK YOU to all the DES activists out there who are speaking up on behalf of the families affected by the DES drug tragedy.

 It’s Time for Actions: did you SIGN THE PETITION ?

The Mammogram I have Not had

Exactly the struggles DES Daughters are experiencing in the UK

Read The Mammogram I Have Not Had by DaphneA brilliant blog post which shows exactly the struggles DES Daughters like me and others are experiencing in the UK when it comes to getting breast screenings

Thanks Daphne! Read The Mammogram I Have Not Had.
All posts tagged Breast Cancer.

DES and Breast Cancer (UK)

More DES DiEthylStilbestrol Resources

Distilbène 25 mg DES Drug Tablets manufactured by Ucepha on Flickr

 Distilbène 25 mg DES Drug Bottle manufactured by Ucepha on FlickrDid your mum take DES? This Distilbene 25mg drug tablets image could help you ask and find out…

See more DES drugs photo set on flick DES Diethylstilbestrol's photostream on Flickr

If you already have a flick account,
add us as a contact
Email your photos to des.daughter@gmail.com with a short description and title :-) – it’s Time for Actions: did you SIGN THE PETITION ?

Will @LillyPad pull a @LanceArmstrong : call @Oprah , admit to the Lies about DES? #KeepLillyHonest

Read Maybe DES Will Finally Get its Day by Caitlin McCarthyDES Activist and DES Daughter Caitlin McCarthy says:
Lilly should just admit that DES has been shown to cause breast cancer and honor its promise to settle lawsuits. They’ve been saying this for more than a year now, and they haven’t done it. This is just going to get more embarrassing if they don’t. Lilly’s CEO needs to pull a Lance Armstrong, call Oprah Winfrey, and admit to the lies about DES
Read her post Maybe DES Will Finally Get its Day
It’s Time for Actions: did you SIGN THE PETITION ?

More about Eli Lilly

More about Caitlin McCarthy

IVF on Steroids: the Dangerous Off-Label use of ‘Dex’ during Pregnancy

It also sounded too close to the history of DES (diethylstilbestrol)

IVF on Steroids: The Dangerous Off-Label Use of 'Dex' During Pregnancy

Fertility clinics across the U.S. are prescribing a medication with a seriously concerning safety profile and no proven benefits

Will the lessons from the DES drug tragedy ever be learned? …
Read IVF on Steroids: The Dangerous Off-Label Use of ‘Dex’ During Pregnancy
theatlantic, JAN 16, 2013.

DES Pregnancy – Time for Actions: did you SIGN THE PETITION ?

It is estimated that one in six Women who were prescribed DES will develop Breast Cancer

DES and Breast Cancer

DES and Breast Cancer

It is estimated that one in six women who were prescribed DES will develop breast cancer, whereas one in eight women in the general population will develop the disease

More DES DiEthylStilbestrol Resources

Diethylstilbestrol, No Pregnancy, No Motherhood

DES : a LifeTime Poisonous Ball and Chain to Carry…

Diethylstilbestrol DES, No Pregnancy, No Motherhood, but a LifeTime Poisonous Ball and Chain to CarryDES Pregnancy – Time for Actions: did you SIGN THE PETITION ?

Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…

More DES DiEthylStilbestrol Resources

Seven Tips to reduce your Number One Source of BPA Exposure

How to reduce BPA levels by 60 percent in 3 days

How to reduce BPA levels by 60 percent in 3 days
How to reduce BPA levels by 60 percent in 3 days

BPA is a toxic chemical used in the lining of most food cans. Bisphenol-A is a synthetic estrogen like DES, linked to breast cancer, reproductive problems, obesity, ADHD, immune system harm and other serious health issues.

You can easily reduce your BPA exposure by avoiding consumption of canned foods that are acidic, salty or fatty, because BPA is more likely to leach from can linings into these kinds of foods.

Read How to reduce BPA levels by 60 percent in 3 days,
by breastcancerfund, March 29, 2011.