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Month: February 2013
2011 DES Symposium acknowledges worldwide DES Tragedy
The Boston USA 2011 DES Symposium acknowledged that the diethylstilbestrol pregnancy drug worldwide tragedy is not something of the past …
See DES (Diethylstilbestrol) Symposium – the DES Tragedy Is Far From Over on Care2 community
Time for Actions: did you SIGN THE PETITION ?
Adverse Effects of a synthetic Oestrogen prescribed to Millions… A Selection of Books on Pinterest
My Pinterest selection of books about the adverse effects of a synthetic oestrogen prescribed to millions …
DES Daughter‘s Pinterest Boards
Time for Actions: did you SIGN THE PETITION ?
CALLING ALL DES Daughters in the UK for Media Opportunity about Breast Cancer Victims
A UK journalist who has been trying to get TV channels interested in a programme on DES Daughters for more than a year has now got a proposal under consideration, following the out of court settlement in the US which related to breast cancer claimants. He needs to find a British breast cancer victim who can show, without doubt, that her mother took DES. This is a unique opportunity. If you can help please contact us or by email des.daughter@gmail.com
Scientists grow Cells capable of fighting Cancer and HIV
Immune system ‘booster’ may hit cancer
Vast numbers of cells that can attack cancer and HIV have been grown in the lab, and could potentially be used to fight disease …
2013 Study Summary
Adoptive immunotherapy with functional T cells is potentially an effective therapeutic strategy for combating many types of cancer and viral infection. However, exhaustion of antigen-specific T cells represents a major challenge to this type of approach. In an effort to overcome this problem, we reprogrammed clonally expanded antigen-specific CD8+ T cells from an HIV-1-infected patient to pluripotency. The T cell-derived induced pluripotent stem cells were then redifferentiated into CD8+ T cells that had a high proliferative capacity and elongated telomeres. These “rejuvenated” cells possessed antigen-specific killing activity and exhibited T cell receptor gene-rearrangement patterns identical to those of the original T cell clone from the patient. We also found that this method can be effective for generating specific T cells for other pathology-associated antigens. Thus, this type of approach may have broad applications in the field of adoptive immunotherapy.
- Read Immune system ‘booster’ may hit cancer
by James Gallagher, Health and science reporter, BBC News. - Sources Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation, Science Direct, Volume 12, Issue 1, 3 January 2013, Pages 114–126 – Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells, Science Direct, Volume 12, Issue 1, 3 January 2013, Pages 31–36.
Le Distilbène DES et les Réunions Juridiques d’Information et de Débat 2011 / 2012
Réunion du 11 mai 2012
- Que nous apprend la jurisprudence?
- La procédure engagée par les “filles DES” américaines ayant eu un cancer du sein
- La “class action” en France
- Télécharger le compte-rendu de cette réunion
Réunion du 1er juillet 2011
- Dossier Distilbène® touchant à la 3ème génération
- La “class action” en France
- Télécharger le compte-rendu de cette réunion
Endocrine-Disrupting Chemicals Identification Protocols are inadequate
Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society
Diethylstilbestrol DES is the first synthetic estrogen and the first chemical known to act as an endocrine disruptor.
In a Statement of Principles unveiled today, The Endocrine Society proposes a streamlined definition for endocrine-disrupting chemicals (EDCs) and offers recommendations that will strengthen the ability of current screening programs to identify EDCs.
Read Experts Say Protocols for Identifying Endocrine-Disrupting Chemicals Inadequate.
Abstract
An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential for deleterious effects of EDC must be considered relative to the regulation of hormone synthesis, secretion, and actions and the variability in regulation of these events across the life cycle. The developmental age at which EDC exposures occur is a critical consideration in understanding their effects. Because endocrine systems exhibit tissue-, cell-, and receptor-specific actions during the life cycle, EDC can produce complex, mosaic effects. This complexity causes difficulty when a static approach to toxicity through endocrine mechanisms driven by rigid guidelines is used to identify EDC and manage risk to human and wildlife populations. We propose that principles taken from fundamental endocrinology be employed to identify EDC and manage their risk to exposed populations. We emphasize the importance of developmental stage and, in particular, the realization that exposure to a presumptive “safe” dose of chemical may impact a life stage when there is normally no endogenous hormone exposure, thereby underscoring the potential for very low-dose EDC exposures to have potent and irreversible effects. Finally, with regard to the current program designed to detect putative EDC, namely, the Endocrine Disruptor Screening Program, we offer recommendations for strengthening this program through the incorporation of basic endocrine principles to promote further understanding of complex EDC effects, especially due to developmental exposures.
Read Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society, Endocrinology. doi: 10.1210/en.2012-1422, 2012 Sep; 153(9): 4097–4110.
Your Relationships after a Baby… Things no one tells you about…
Do you have some tips to share? Let us know in the comments!
Bringing a baby into the home has been likened to throwing a hand grenade in between you and your partner
Read Things No One Tells You About Relationships After Baby,
pregnancy.org, 2013.
Stilboestrol 1 mg, in 1cc – “Poison”
By Ward, Blekinshop & Co. Ltd, London, Liverpool, made in England
Did your mum take DES?
This Stilboestrol 1mg drug box image could help you ask and find out…
Find more DES drugs images and photo sets on Flickr
If you already have a Flickr® account, add us as a contact – Email your photos to des.daughter@gmail.com with a short description and title
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.
Is the 2012 Boston Case the first major Litigation alleging a Link between DES and Breast Cancer in DES Daughters?
2012 Boston lawsuit claims DES-breast cancer link
” The characteristics of my cancer were for women over 60 typically. It wasn’t the type of cancer a 40-year-old or a 44-year-old woman gets.
When I read the research that’s been done, I found I had more chance of getting it because my mom took DES ”
said Arline MacCormack, one of 53 women from the USA who are suing Eli Lilly manufacturer of the DES drug.
- Read Boston lawsuit claims DES-breast cancer link.
- Watch Arline MacCormack interview: Eli Lilly @LillyPad_Media Lawsuit – Arline @amaccormack Interview – Boston DES Breast Cancer Trial.
More about Eli Lilly lawsuit
- Boston DES Breast Cancer trial – The Melnick sisters interview.
- When the Melnick sisters’ trial began – The McCarthy family interview.
- When the Melnick sisters reached a settlement with the drug company.
- Time for Actions : did you SIGN THE PETITION?
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.