What is DES and why you should care

EDCs like DES impact human health in ways we are only just beginning to understand

“Yes, there are third generation effects from this drug. Researchers are just beginning to untangle the third generation effects. In women, menstrual irregularities appear more common as do the various forms of cancer, but the data are unclear. In men, hypospodias may be more frequent, but again the data are mixed.”

What is DES and why you should care by @ChanatLucine and @LucineWoman on PinterestRead What is DES and why you should care
by Chandler Marrs MS, MA, PhD Hormone Matter.

More DES DiEthylStilbestrol Resources

We all have #Kred somewhere… Get your Social Analytics, join @DES_Journal

@DES_Journal Kred DashboardWe all have “Kred” somewhere… Analyze your recent activity and learn about your sphere of influence… Guick Start Guide  – Kred.com

Pacific Cod Fish Protein should be a promising antimetastatic Agent for various Cancer Treatments

The use of natural dietary products with anti-tumor activity is an important and emerging field of research

New Study: Fish Protein may Slow Down Cancer MetastasisResearch published in Proceedings of the National Academy of Sciences (PNAS) claims that protein derived from Pacific cod fish may suppress Prostate Cancer and perhaps other cancers from spreading. The research carried out by the researchers at the University Of Maryland School Of Medicine. ”

Read New Study: Fish Protein may Slow Down Cancer Metastasis , DNA, 20 Mar 2013.

Bisphenol A (BPA) found in Ocean Water and Sand, contaminating for long into the Future

BPA contamination likely comes from a mix of boat paint and plastic

Chemical From Plastic Water Bottles Found Throughout OceansA survey of 200 sites in 20 countries around the world has found that bisphenol A (BPA), an estrogen-like endocrine-disrupting chemical like DES that is linked to developmental disorders, is not only affecting our health but our oceans and its wildlife

Read Chemical from plastic water bottles found throughout oceans
by Brandon Keim, wired, 03.24.10.

Fetal Surgery Researchers looking for Ways to reduce Risks, operate earlier, treat more Conditions

The Tiniest Patients: Fetal Surgery Delivers Big Results

The Tiniest Patients: Fetal Surgery Delivers Big ResultsThe Future of Fetal Surgery

Efforts under way in fetal surgery involve using less invasive or earlier treatments. One hope is that procedures done today for fetuses who are twentysome weeks old could be done sooner, with greater benefit. ”

Read The Tiniest Patients: Fetal Surgery Delivers Big Results
by Joseph Brownstein, livescienc, July 17, 2012.

Statistics prove that Prescription Drugs are 16,400% more deadly than Terrorists…

The corruption in the pharmaceutical industry and in America’s healthcare system poses a far greater threat to the health, safety and welfare of Americans today than terrorism

Statistics prove that Prescription Drugs are 16,400% more deadly than Terrorists...

On Flickr®

2013 Model may help predict Women’s final Menstrual Period, Researchers reported

Could it help patients and researchers estimate the time to FMP?

Model May Predict Final Menstrual PeriodPredicting the final menstrual period (FMP) would help women know when their menopause transition will be completed. A new model using levels of two hormones may help predict when perimenopausal women will have their final period, researchers reported.

Read Model May Predict Final Menstrual Period
by Kristina Fiore, MedPage Today, March 28, 2013.

Abstract

Context:
Predicting the final menstrual period (FMP) would help women know when their menopause transition will be completed. Additionally, biological changes, such as accelerated bone loss, precede the FMP by at least 1 year.

Objective:
Our objective was to assess whether FSH, estradiol, or urinary N-telopeptide predict where an individual is on her timeline to FMP.

Methods:
The sample was 554 women from the Study of Women’s Health Across the Nation. We modeled the probability of having crossed specified landmarks: 2 years before, 1 year before, and the FMP. We also modeled the probability of being in narrower intervals: 2 to1 year before FMP, 2 years before FMP and FMP, or 1 year before FMP and FMP. We determined the candidate markers that best predicted having crossed each landmark, with the optimum defined as the greatest area under the receiver-operator curve; created formulas for the probability of having crossed each landmark; and calculated sensitivity and specificity.

Results:
Final models included current estradiol and FSH (each as a fraction of 1 previous reference measure), age, menopause transition stage, race/ethnicity, and whether serum was collected during the early follicular phase. Areas under the receiver-operator curves of final models that predicted the probability of a woman having crossed 2 years before, 1 year before, and the FMP itself were 0.902, 0.926, and 0.945, respectively. If we classified women as having crossed the 2 years before the FMP landmark when predicted probability exceeded 0.3, sensitivity was 85% and specificity 77%.

Conclusion:
This model could help patients and researchers estimate the time to FMP.

Sources: Predicting the Timeline to the Final Menstrual Period:
The Study of Women’s Health Across the Nation

“Nice study but will it predict it in the DES Exposed…” said DES Info

Le Distilbène Etude 3 Générations, portée par Réseau DES France et l’ ANSM

Les résultats sont maintenant publiés ; téléchargez le guide pratique

Distilbène Etude 3 Générations, portée par Réseau DES France et l'ANSM... sur FlickrL’Association Réseau DES France

Les résultats publiés

Le Distilbène DES, en savoir plus
Rejoigez-nous sur Flick

Cancer Monitoring by identifying tiny circulating Bits of Tumor DNA

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

Circulating Tumor DNA posted by Jamie ColbertWhat if instead of looking for circulating tumor surrogates, we actually tried to identify circulating bits of actual tumor?

One method to do this is to assay for pieces of circulating tumor DNA.

Read Circulating Tumor DNA posted by Jamie Colbert.

Abstract

BACKGROUND
The management of metastatic breast cancer requires monitoring of the tumor burden to determine the response to treatment, and improved biomarkers are needed. Biomarkers such as cancer antigen 15-3 (CA 15-3) and circulating tumor cells have been widely studied. However, circulating cell-free DNA carrying tumor-specific alterations (circulating tumor DNA) has not been extensively investigated or compared with other circulating biomarkers in breast cancer.

METHODS
We compared the radiographic imaging of tumors with the assay of circulating tumor DNA, CA 15-3, and circulating tumor cells in 30 women with metastatic breast cancer who were receiving systemic therapy. We used targeted or whole-genome sequencing to identify somatic genomic alterations and designed personalized assays to quantify circulating tumor DNA in serially collected plasma specimens. CA 15-3 levels and numbers of circulating tumor cells were measured at identical time points.

RESULTS
Circulating tumor DNA was successfully detected in 29 of the 30 women (97%) in whom somatic genomic alterations were identified; CA 15-3 and circulating tumor cells were detected in 21 of 27 women (78%) and 26 of 30 women (87%), respectively. Circulating tumor DNA levels showed a greater dynamic range, and greater correlation with changes in tumor burden, than did CA 15-3 or circulating tumor cells. Among the measures tested, circulating tumor DNA provided the earliest measure of treatment response in 10 of 19 women (53%).

CONCLUSIONS
This proof-of-concept analysis showed that circulating tumor DNA is an informative, inherently specific, and highly sensitive biomarker of metastatic breast cancer. (Funded by Cancer Research UK and others.)

Sources – the NEJM new proof-of-concept study:
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer, March 28, 2013.

Chemotherapy damages healthy Cells; boosts Tumour Growth, Resistance to further Cancer Treatment

Chemotherapy can backfire and make Cancer worse by triggering Tumor Growth

Surprised? US Scientists Find That Chemotherapy Boosts Cancer GrowthChemotherapy can damage healthy cells? Say it isn’t so? You don’t need a degree to figure this one out. Poison kills indiscriminately– always has and always will. While damaging healthy cells, chemotherapy also triggers them to secrete a protein that sustains tumour growth and resistance to further treatment. Researchers in the United States made the “completely unexpected” finding they claimed while seeking to explain why cancer cells are so resilient inside the human body when they are easy to kill in the lab.”

Read Surprised? US Scientists Find That Chemotherapy Boosts Cancer Growth

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