A 2005 NIEHS Study where DES appears to permanently disrupt the hormonal mechanisms regulating body weight…
… ” Exposure to tributyltin is increasing the number of fat cells, so the individual will get fatter faster as these cells produce more of the hormones that say ‘feed me ” … ” Once these genetic changes happen in utero, they are irreversible and with the individual for life ” …
Taken together, our data support the idea that brief exposure to low levels of environmental estrogens early in life increases body weight as the mice age. Whether our results can be extrapolated to humans, as in the reproductive abnormalities from the DES mouse model, remains to be determined, but this is a fruitful area for further research. In addition, the use of this mouse model to study mechanisms involved in altered weight homeostasis (direct and/or endocrine feedback loops, e.g., ghrelin, leptin) by environmental endocrine disrupting chemicals is an important basic research area that may shed light on the future prevention and treatment of obesity.
- Read Chemicals May Play Role in Rise in Obesity
by Elizabeth Grossman, TheWashingtonPost, March 2007.
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.