Significant Relationship between Children Urinary BPA Levels and Asthma Diagnosis

Kids exposed to a commonplace chemical early in life are more likely to have asthma

Read New Study Links BPA and Childhood AsthmaLast week, a study of hundreds of children in New York City showed a significant relationship between levels of urinary BPA at ages 3, 5, and 7 and asthma diagnosis at ages 5-12.
Previous studies with laboratory animals have found a similar link…

Abstract

Background:
Bisphenol A (BPA) is used widely to manufacture food container linings. Mouse models suggest exposure to BPA might increase allergic inflammation.

Objectives:
We hypothesized that BPA exposure, as assessed based on urinary BPA concentrations, would be associated with increased odds of wheeze and asthma and increased fraction of exhaled nitric oxide (FENO) values in children.

Methods:
The Columbia Center for Children’s Environmental Health recruited pregnant women for a prospective birth cohort study (n 5 568). Mothers during the third trimester and children at ages 3, 5, and 7 years provided spot urine samples. Total urinary BPA concentrations were measured by using online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry. Wheeze in the last 12 months was measured by using questionnaires at ages 5, 6, and 7 years. Asthma was determined by a physician once between ages 5 and 12 years. FENO values were measured at ages 7 to 11 years.

Results:
Prenatal urinary BPA concentrations were associated inversely with wheeze at age 5 years (odds ratio [OR], 0.7; 95% CI, 0.5-0.9; P 5 .02). Urinary BPA concentrations at age 3 years were associated positively with wheeze at ages 5 years (OR, 1.4; 95% CI, 1.1-1.8; P 5 .02) and 6 years (OR, 1.4; 95% CI, 1.0-1.9; P 5.03). BPA concentrations at age 7 years were associated with wheeze at age 7 years (OR, 1.4; 95% CI, 1.0-1.9; P 5 .04) and FENO values (b 5 0.1; 95% CI, 0.02-0.2; P 5 .02). BPA concentrations at ages 3, 5, and 7 years were associated with asthma (OR, 1.5 [95% CI, 1.1-2.0], P 5 .005; OR, 1.4 [95% CI, 1.0-1.9], P 5 .03; and OR, 1.5 [95% CI, 1.0-2.1], P 5 .04, respectively).

Conclusions:
This is the first report of an association between postnatal urinary BPA concentrations and asthma in children. (J Allergy Clin Immunol 2013;131:736-42.)

  • Read New Study Links BPA and Childhood Asthmascientificamerican, March 1, 2013.
  • Read Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children, environmentalhealthnews, 2013.

Endocrine-disrupting Chemicals impact on Obesity for those exposed in-Utero

Developmental exposure to estrogenic compounds and obesity

Chemicals May Play Role in Rise in ObesityA 2005 NIEHS Study where DES appears to permanently disrupt the hormonal mechanisms regulating body weight…

… ” Exposure to tributyltin is increasing the number of fat cells, so the individual will get fatter faster as these cells produce more of the hormones that say ‘feed me ” … ” Once these genetic changes happen in utero, they are irreversible and with the individual for life ” …

Abstract

Taken together, our data support the idea that brief exposure to low levels of environmental estrogens early in life increases body weight as the mice age. Whether our results can be extrapolated to humans, as in the reproductive abnormalities from the DES mouse model, remains to be determined, but this is a fruitful area for further research. In addition, the use of this mouse model to study mechanisms involved in altered weight homeostasis (direct and/or endocrine feedback loops, e.g., ghrelin, leptin) by environmental endocrine disrupting chemicals is an important basic research area that may shed light on the future prevention and treatment of obesity.

DES and Obesity

More DES DiEthylStilbestrol Resources

International Women’s Day!

Celebrate DES Mothers and Daughters advocating for all DES Victims

International #WomensDay! Celebrate DES Mothers and Daughters advocating for all DES VictimsWho’s the woman who has inspired you the most and why? Personally I’m celebrating these women on the collage who are truly amazing and a true inspiration and that includes my Mum! … Happy Women’s Day!
See more DES Activists on Pinterest Follow DES Daughter on Pinterest

More DES DiEthylStilbestrol Resources

Exposure to the Chemicals in everyday Objects poses a hidden Health Threat

Toxins All around Us

Read Toxins All around Us by Patricia HuntScientists have become increasingly worried that even extremely low levels of some environmental contaminants may have significant damaging effects on our bodies—and that fetuses are particularly vulnerable to such assaults. ”

Scientists and clinicians across diverse disciplines are concerned that the efforts of the EPA and the FDA are insufficient in the face of the complex cocktail of chemicals in our environment. ”

Read Toxins All around Us by Patricia Hunt, October 1, 2011

Breast Cancer Insurance Coverage: Breast Cancer Genetic Testing covered by Health Care Reform

Breast Cancer Genetic Testing Gets Covered by Health Care ReformGenetic testing for breast cancer will be covered under the Affordable Care Act, potentially saving women who need the test thousands of dollars.

Read Breast Cancer Genetic Testing Gets Covered by Health Care Reform by Rachael Rettner, MyHealthNewsDaily

FDA: if BPA does not belong to Baby Bottles, why does it belong to Food Packaging?

Studies have linked BPA to everything from increased risks of certain cancers, to diabetes, reproductive abnormalities, infertility, heart disease…

FDA Finally Decides That BPA Doesn’t Belong In Baby Bottles… it was announced that baby bottles and sippy cups can no longer contain BPA. ”

Even though the FDA proudly declared that “Consumers can be confident that these products do not contain BPA,” it then adds, “The agency continues to support the safety of BPA for use in products that hold food.”  So the FDA is saying we should feel confident it banned the use of a chemical it doesn’t actually believe is dangerous?

Read FDA Finally Decides That BPA Doesn’t Belong In Baby Bottles, consumerist, July 17, 2012.

Apology overdue to Victims of Miscarriage Drug

A Sept 2002 letter by Carol Devine, DES Action Australia-NSW

Apology overdue to victims of miscarriage drugThe drug company Grunenthal’s ”apology” goes beyond being insulting to all the unfortunate victims of thalidomide –  read Thalidomide maker’s apology ‘insulting’  – This company has set the benchmark in deceitful spin for all future ”apologies” for drug disasters.

Millions of dollars have been paid out by drug companies in US out-of-court settlements to people exposed in the womb to the anti-miscarriage drug DES (diethylstilboestrol). Yet, not one drug company has ever apologised for the DES tragedy. The DES case exposed between 6 million and 12 million people in the US and many thousands outside America, including the estimated 740,000 in Australia. ” a Sept 2002 letter by Carol Devine, DES Action Australia-NSW.

DES DiEthylStilbestrol Resources

Probably what Doctors would prescribe more often if not pressured by Pharmaceutical Companies

We know it and still ignore it…

Probably what doctors would prescribe more often if not pressured by pharmaceutical companies ...

See more Comics – about Doctors and Medical Representatives
Our posts about prescriptions drugs – the FDA and the Pharmaceutical Industry

Eating fresh, local and organic might not be sufficient to avoid Bisphenol A and Phthalates

Buying Local and Organic? You’re Still Eating Plastic Chemicals

Eating fresh, local and organic might not be sufficient to avoid Bisphenol A (BPA) and PhthalatesA team led by Sheela Sathyanarayana of University of Washington’s Seattle Children’s Research Institute performed a “dietary intervention” on two sets of five local families… …using urine tests to establish baseline BPA and phthalate levels for each group… ”

The lesson is that you can try to reduce exposure, but there are unknown sources of phthalates that could be very large lurking in the food chain. ”

These results add to a weight of evidence that should push the FDA to take action on the role of plastic conditioners in food processing and packaging. ”

Read Buying Local and Organic? You’re Still Eating Plastic Chemicals, MotherJones, MAR. 4, 2013.