Taking anti-depressants in early Pregnancy linked to Child Heart Defects

Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study

Anti-depressants pregnancy 'risk'
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Children born to women taking anti-depressants in early pregnancy have a small but important increased risk of heart defects, Danish researchers say.

Abstract

Objective
To investigate any association between selective serotonin reuptake inhibitors (SSRIs) taken during pregnancy and congenital major malformations.

Design
Population based cohort study.

Participants
493 113 children born in Denmark, 1996-2003.

Main outcome measure
Major malformations categorised according to Eurocat (European Surveillance of Congenital Anomalies) with additional diagnostic grouping of heart defects. Nationwide registers on medical redemptions (filled prescriptions), delivery, and hospital diagnosis provided information on mothers and newborns. Follow-up data available to December 2005.

Results
Redemptions for SSRIs were not associated with major malformations overall but were associated with septal heart defects (odds ratio 1.99, 95% confidence interval 1.13 to 3.53). For individual SSRIs, the odds ratio for septal heart defects was 3.25 (1.21 to 8.75) for sertraline, 2.52 (1.04 to 6.10) for citalopram, and 1.34 (0.33 to 5.41) for fluoxetine. Redemptions for more than one type of SSRI were associated with septal heart defects (4.70, 1.74 to 12.7)). The absolute increase in the prevalence of malformations was low—for example, the prevalence of septal heart defects was 0.5% (2315/493 113) among unexposed children, 0.9% (12/1370) among children whose mothers were prescribed any SSRI, and 2.1% (4/193) among children whose mothers were prescribed more than one type of SSRI.

Conclusion
There is an increased prevalence of septal heart defects among children whose mothers were prescribed an SSRI in early pregnancy, particularly sertraline and citalopram. The largest association was found for children of women who redeemed prescriptions for more than one type of SSRI.

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Author: DES Daughter

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.

2 thoughts on “Taking anti-depressants in early Pregnancy linked to Child Heart Defects”

  1. That’s an amazing study. It’s amazing how much children can suffer from what there mothers do during pregnancy. Babies with defects such as this could really stand to seek treatment from nyc cardiology experts. You should never slack on treatment, so why not go to the best. Thanks for posting.
    Steve

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