Dietary supplements: vitamins can do more Harm than good…
Beginning in February 2013, Dr. Kenneth Spaeth began seeing the first of a group of patients that shared similar symptoms and abnormalities in laboratory tests of the liver, thyroid and cholesterol levels. They came to see him concerned that it was an exposure to pesticides or some other chemical that had caused those signs and symptoms. It turned out that the only commonality was the vitamin supplements they took: same brand and same type…
Can drugs shield sensitive gastrointestinal tract from toxic effects?
Scientists may have found a way of protecting cancer patients from the lethal effects of radiotherapy and chemotherapy using drugs that shield the sensitive gastrointestinal tract from the toxic effects of the treatment.
Pregnancy outcomes in DES-exposed women are worse than those in unexposed women
2000 Study Abstract
To evaluate long-term pregnancy experiences of women exposed to diethylstilbestrol (DES) in utero compared with unexposed women.
This study was based on diethylstilbestrol-exposed daughters, the National Collaborative Diethylstylbistrol Adenosis cohort and the Chicago cohort, and their respective nonexposed comparison groups. Subjects who could be traced were sent a detailed questionnaire in 1994 that contained questions on health history, including information on pregnancies and their outcomes. We reviewed 3373 questionnaires from exposed daughters and 1036 questionnaires from unexposed women.
The response rate was 88% among exposed and unexposed women. Diethylstilbestrol-exposed women were less likely than unexposed women to have had full-term live births and more likely to have had premature births, spontaneous pregnancy losses, or ectopic pregnancies. Full-term infants were delivered in the first pregnancies of 84.5% of unexposed women compared with 64. 1% of exposed women identified by record review (relative risk [RR] 0.76, confidence interval [CI] 0.72, 0.80). Preterm delivery of first births occurred in 4.1% of unexposed compared with 11.5% of exposed women, and ectopic pregnancies in 0.77% of unexposed compared with 4.2% of exposed women. Spontaneous abortion was reported in 19.2% of DES-exposed women compared with 10.3% in control women (RR 2.00, CI 1.54, 2.60). According to complete pregnancy histories (many women had more than one pregnancy), preterm births were more common in DES-exposed women (19.4% exposed versus 7.5% unexposed (RR 2.93 CI 2.23, 3.86). Second-trimester spontaneous pregnancy losses were more common in DES-exposed women (6.3% versus 1.6%; RR 4.25, CI 2.36, 7.66). More first-trimester spontaneous abortions occurred in DES-exposed women than in controls (RR 1.31, CI 1.13, 1.53), and DES-exposed women had at least one ectopic pregnancy more often than unexposed women (RR 3.84, CI 2.26, 6.54).
Pregnancy outcomes in DES-exposed women were worse than those in unexposed women.
Children who were breast-fed for longer as babies do better on a test of language comprehension at age three, and intelligence at age seven, according to a new study. The researchers looked at many potential confounding factors, but the link held, they said.
” Dr. J. Michael Gaziano, a cardiologist at Brigham and Women’s Hospital and the V.A. Boston Healthcare System who is the lead author of a recent multivitamin study, said the main reason to take a multivitamin was, and continues to be, to prevent nutritional deficiencies. He was reluctant to speculate about how a multivitamin might curb cancer. One of the dominant hypotheses, he noted, is that certain vitamins are antioxidants that protect aging cells against oxidative damage caused by free radicals, harmful molecules resulting from metabolic processes within cells. ”
Currently, over 400 cases of clear cell adenocarcinoma of the vagina and cervix occurring in females born after 1940 have been accessioned into the Registry for Research on Hormonal Transplacental Carcinogenesis. Cases have been identified throughout the United States as well as Australia, Canada, Mexico, and Europe. Intrauterine exposure to DES and similar nonsteroidal estrogens have been uncovered in about two-thirds of the cases with an available maternal history. A peak in the age incidence curve of the DES-related cases has been observed at about 19 years with the age range being 7-30 years. The five-year survival for 400 patients has been 80%. Numerous nonmalignant epithelial changes have been observed. It appears that there has not been an increase in the occurrence of premalignant or malignant squamous cell lesions among the DES exposed. Premature birth has been more common among DES-exposed women. For those in whom there is evidence of a midpregnancy loss or premature ripening of the cervix during pregnancy, a cerclage procedure has been effective in producing a desirable outcome.
Aujourd’hui, on étudie enfin les effets à long terme du DES
Regardez la page n°5 de l’article paru dans La Recherche mensuel n°476 daté juin 2013, composé par Emmanuelle Fillion, sociologue de la santé, maître de conférences à la Maison des sciences sociales du handicap (CNSA/EHESP) et Didier torny, sociologue, directeur de recherche à l’Institut national de la recherche agronomique.
Effects of prenatal exposures to drugs on childhood development
” When a pregnant woman takes a drug, three generations are exposed simultaneously: the mother, the fetus, and, due to the fetal germline exposure, the future grandchildren. Far from being inert marbles of imperturbable DNA, fetal egg and sperm are sensitive and responsive to the uterine environment. This is largely due to a molecular phenomenon called “epigenetics,” which refers to the complex landscape of countless millions of tiny chemical switches that control gene expression. ”
Higher infertility rate and abnormalities found in the DES Daughters
Infertility was examined among 343 diethylstilbestrol-exposed and 303 unexposed daughters whose mothers participated in an evaluation of diethylstilbestrol use during pregnancy 35 years ago. Of the married individuals who were not using contraception and who were actively trying to conceive, a greater proportion of diethylstilbestrol-exposed women than unexposed subjects experienced primary infertility (33% versus 14%, p less than 0.001). Among those with primary infertility, abnormal hysterosalpingograms were observed in 46% of the diethylstilbestrol-exposed group and in none of the unexposed group (p less than 0.02), while tubal abnormalities were found in 42% of the exposed and in none of the unexposed (p = 0.02). First pregnancies were achieved by 40 (58%) women exposed to diethylstilbestrol and 18 (64%) unexposed subjects. Twenty-four (60%) of the exposed women and 15 (83%) of the unexposed individuals who conceived had a live-born infant who survived. The estimated cumulative rate of first pregnancy was 16% for the exposed group and 36% for the unexposed group at 12 months after the diagnosis of primary infertility (p less than 0.05).
Aujourd’hui, on étudie enfin les effets à long terme du DES
Regardez la page n°4 de l’article paru dans La Recherche mensuel n°476 daté juin 2013, composé par Emmanuelle Fillion, sociologue de la santé, maître de conférences à la Maison des sciences sociales du handicap (CNSA/EHESP) et Didier torny, sociologue, directeur de recherche à l’Institut national de la recherche agronomique.