Bisphenol A: Perinatal Exposure and Body Weight

BPA explained ; go more in depth

Abstract

Bisphenol A: Perinatal Exposure and Body Weight
Chemical structures of BPA, DES and estradiol

Bisphenol A (BPA) is a component of polycarbonate and other plastics including resins that line food and beverage containers. BPA is known to leach from products in contact with food and drink, and is therefore thought to be routinely ingested. In a recent cross sectional study, BPA was detected in urine samples from 92.6% of the US population examined. The potential for BPA to influence body weight is suggested by in vitro studies demonstrating effects of BPA on adipocyte differentiation, lipid accumulation, glucose transport and adiponectin secretion. Data from in vivo studies have revealed dose-dependent and sex dependent effects on body weight in rodents exposed perinatally to BPA. The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed.

Read Bisphenol A: Perinatal Exposure and Body Weight
NCSI, March 9 2009.

After watching “Bisphenol A explained on Video… What is BPA and where is it used?“, you can go more in depth and find all you need to know about the endocrine disruptor BPA. The 2nd paragraph covers the similarities between BPA and DES!

DES DiEthylStilbestrol Resources

Author: DES Daughter

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.

3 thoughts on “Bisphenol A: Perinatal Exposure and Body Weight”

  1. From that paper, “… the lowest-observable-adverse-effect-level (LOAEL) for BPA was determined at 50 mg/kg BW/day”. For a 100 kilogram human being, that translates into a daIly dose of 5 grams (about a teaspoonful) to produce any observable effects! Compare that with DES, where a single dose of 10 micrograms – 10 millionths of a gram – is enough to produce clinically observable estrogenic effects. DES is literally a million times more potent as an estrogen than BPA!

    Those two dimensional representations of the molecules you’ve shown make the structures of BPA and DES look very similar, but in reality their 3 dimensional structures will be completely different.

    DES contains two phenyl groups joined by an ethylene bridge, and molecules containing that particular strucure have the ability to interfere with microtubule synthesis and produce cells with abnormal numbers of chromosomes. These cells can later become cancerous, which is why DES is carcinogenic. Although BPA contains two phenyl groups also, they’re not joined by an ethylene bridge and so BPA is unlikely to be carcinogenic (or if it is, it’ll be through some different mechanism).

    In other words, DES and BPA are two totally different things, and yet there seems to be a major effort underway to conflate the two in the public consciousness. Who’s behind it? My guess is that it’s the pharmaceutical industry, and that they’re trying to make DES and EDCs one and the same as far as the public are concerned. Then, in 20 or 30 years time when most of us are dead, they’ll grandly unmask EDCs as a hoax, and that’ll be that as far as DES is concerned (and probably a few other nasties from the wonder drug years that they’ve swept under the EDCs umbrella as well!).

    Well, maybe I’m being a bit paranoid there, but the fact remains that there’s really no comparing environmental toxins with high dosage medical hormone exposure. They’re two completely different things!

    1. This is so complex. It is my understanding that even though DES and BPA are different in many ways they both work as endocrine disruptors and this is why they’re often compared. I see your point though about the pharmaceutical industry’s motivations. Once again, thanks for sharing your knowledge and expertise about DES.

  2. Just to add to what I was saying, if you look on Wikipedia at the molecular representations for DES and BPA
    you’ll see that they are in fact two completely differently shaped molecules, DES having a flat planar shape quite similar to estradiol whereas BPA is kinked into a V shape and bears no resemblance to estradiol at all!

    Unfortunately, there’s a lot of fake scientific research around that was ghostwritten in the marketing departments of pharmaceutical companies, e.g.Ghost-Written Article at Heart of Pharma Fraud Case and One in Five Medical Journal Articles Include Honorary and Ghost Authors, Study Finds

    Perhaps this paper is one of these phoney ghostwitten articles? It’s basically trying to make out that DES is no more harmful than a widely used, relatively nontoxic industrial chemical that people are exposed to every day without suffering any obvious ill effects. That’s the story the pharmaceutical companies would no doubt like people to hear, but it’s completely untrue and I don’t think we should go along with it!

Have your say! Share your views

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s