Diethylstilbestrol DES, the “safe and effective” multi-generational catastrophe
” Prenatal exposure to the once-popular synthetic estrogen drug DES caused a wide variety of developmental disturbances, including urogenital abnormalities, birth defects, infertility, altered gender behavior and identification, autoimmune diseases, psychiatric problems, vaginal cancer, cervical cancer, and breast cancer. Damage is now also confirmed in the grandchildren of the women who took the drugs. Though autism per se is not connected with this particular drug, the DES story provides an illustration of unforeseen multigenerational epigenetic impacts of synthetic hormone exposure. ”
Mothers of multiples are at 44% higher breast cancer risk than women who had singleton pregnancies with IVF
Breast cancer risk is higher for women with twins, triplets, or more via in vitro fertilization (IVF), a population-based study showed, although it also suggested the fertility treatment may not be at fault.
The explanation for the association may not be the multiple pregnancy, but a maternal trait related to a higher implantation potential and to breast cancer itself.
Breast cancer risk is temporarily increased after a full-term pregnancy and declines thereafter, possibly due to increased levels of gonadal and placental hormones during pregnancy. Inconsistent results, however, have been reported after twin pregnancies with higher hormone levels. Among women treated with in vitro fertilisation (IVF), for whom the number of embryos available for implantation is known, we recently observed that a multiple birth after implantation of all transferred embryos is associated with higher levels of vascular endothelial growth factor (VEGF). As VEGF is involved in breast cancer progression, we studied the effects of embryo implantation and a multiple birth on breast cancer risk in a nationwide Dutch cohort of IVF-treated women.
We performed a cohort analysis among 12,589 women who had been treated with IVF between 1983 and 1995 and completed a risk factor questionnaire between 1997 and 1999. Data on IVF treatment were obtained from medical records. Breast cancer cases were ascertained through linkage with the population-based Netherlands Cancer Registry. Breast cancer risks associated with singleton and multiple births were estimated with Cox regression.
There were 1688 women (13.4%) with multiples, 6027 (47.9%) with singletons and 4874 (38.7%) nulliparous women. Breast cancer occurred in 317 women of whom 57 had multiples. Breast cancer risk was 1.44 times higher in mothers of multiples than in mothers of singletons (95% confidence interval (CI) 1.06-1.97). Risk was highest in women who gave birth to multiples from all embryos transferred (adjusted hazard ratio (HR) 1.86, 95% CI 1.01-3.43), and lower for those with multiples after incomplete embryo implantation (adjusted HR 1.31, 95% CI 0.76-2.25).
A woman’s potential to implant all transferred embryos may be associated with breast cancer risk. Further research is needed to confirm our results and to identify the underlying biological mechanisms.
Sadly for many DES daughters having their own children is not possible! Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…
Bisphenol A (BPA) is a component of polycarbonate and other plastics including resins that line food and beverage containers. BPA is known to leach from products in contact with food and drink, and is therefore thought to be routinely ingested. In a recent cross sectional study, BPA was detected in urine samples from 92.6% of the US population examined. The potential for BPA to influence body weight is suggested by in vitro studies demonstrating effects of BPA on adipocyte differentiation, lipid accumulation, glucose transport and adiponectin secretion. Data from in vivo studies have revealed dose-dependent and sex dependent effects on body weight in rodents exposed perinatally to BPA. The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed.
BPA as an estrogen
BPA’s actions as an estrogen may contribute to effects on body weight. Sex-dependent and dose-dependent differences in body weight in response to early postnatal exposure to DES, an estrogenic compound with structural similarities to BPA have been reported. Those studies demonstrated increased body weight at 4 months of age in females exposed to DES (1 μg DES/day) from postnatal days 1 through 5. In contrast, males exposed to DES during that time period demonstrated a decrease in body weight relative to controls at 4 months of age. The administration of another estrogenic compound, the soy isoflavone, genistein to 4 week old male and female mice (in doses of 50–200,000 μg/kg/day for 15 days) also revealed dose and sex-dependent effects on adipose tissue deposition. In this specific paradigm, the males proved to be more sensitive to the effects of genistein showing increased adipose tissue deposition following treatment with nutritional doses of genistein and a significant decrease in fat pads when they were treated with pharmacological doses of the compound. It is intriguing to note that continuous exposure of male mice from conception through adulthood to a high phytoestrogen diet (containing high levels of genistein as well as diadzein) resulted in decreased adiposity, increased energy expenditure, and improved glucose and lipid metabolism. These data further suggest the importance of the dose and the precise timing of exposure to estrogenic compounds as well as the compounds themselves in determining their effects on adiposity and glucose homeostasis.
British doctors reveal important research that could help thousands of women at risk
Scientists at Warwick University have developed a £10 test that gives advance warning of postnatal depression, which will allow women to have early treatment that could even stop the condition taking hold. The test could be in widespread use within five years and the researchers said it could revolutionise care of pregnant women. Given early in pregnancy, it uses a few drops of blood to determine whether a woman has faulty genes that put her at risk.
A new study published in PlosOne provides evidence of a relationship between dietary patterns, fish intake or n-3 PUFA intake from seafood and symptoms of anxiety in pregnancy, and suggests that dietary interventions could be used to reduce high anxiety symptoms during pregnancy.
According to researchers who questioned 9,500 women about their diet, women who eat fish regularly are 50% less likely to have high anxiety levels at 32 weeks’ gestation (than women who never eat fish).
Little is known about relationships between dietary patterns, n-3 polyunsaturated fatty acids (PUFA) intake and excessive anxiety during pregnancy.
To examine whether dietary patterns and n-3 PUFA intake from seafood are associated with high levels of anxiety during pregnancy.
Pregnant women enrolled from 1991–1992 in ALSPAC (n 9,530). Dietary patterns were established from a food frequency questionnaire using principal component analysis. Total intake of n-3 PUFA (grams/week) from seafood was also examined. Symptoms of anxiety were measured at 32 weeks of gestation with the Crown-Crisp Experiential Index; scores ≥9 corresponding to the 85th percentile was defined as high anxiety symptoms. Multivariate logistic regression models were used to estimate the OR and 95% CI, adjusted by socioeconomic and lifestyle variables.
Multivariate results showed that women in the highest tertile of the health-conscious (OR 0.77; 0.65–0.93) and the traditional (OR 0.84; 0.73–0.97) pattern scores were less likely to report high levels of anxiety symptoms. Women in the highest tertile of the vegetarian pattern score (OR 1.25; 1.08–1.44) were more likely to have high levels of anxiety, as well as those with no n-3 PUFA intake from seafood (OR 1.53; 1.25–1.87) when compared with those with intake of >1.5 grams/week.
The present study provides evidence of a relationship between dietary patterns, fish intake or n-3 PUFA intake from seafood and symptoms of anxiety in pregnancy, and suggests that dietary interventions could be used to reduce high anxiety symptoms during pregnancy.
One of the many concerns some individuals have about family building using alternate methods is what they will tell their child
Sadly for many DES daughters having their own children is not possible!
Many of us who have experienced miscarriages, want to have kids but are struggling or unable to…
“No one should feel ashamed of how they were conceived and educating our youth about the many ways families are formed and babies are made will help foster greater understanding and acceptance for family diversity”
says Erica Berman, PhD.
Long-term statin use and risk of ductal and lobular breast cancer among women 55 to 74 years of age
A new study published in the journal Cancer Epidemiology, Biomarkers and Prevention indicates that women who are long-term users of statin drugs have between 83-143% increased risk of breast cancer.
Low cholesterol has been found to increase the risk of cancer at all sites, further implicating these cholesterol-lowering agents – such as statin drugs – as possible carcinogens.
Mechanistic studies largely support the chemopreventive potential of statins. However, results of epidemiologic studies investigating statin use and breast cancer risk have been inconsistent and lacked the ability to evaluate long-term statin use.
We used data from a population-based case-control study of breast cancer conducted in the Seattle-Puget Sound region to investigate the relationship between long-term statin use and breast cancer risk. Nine hundred sixteen invasive ductal carcinoma (IDC) and 1,068 invasive lobular carcinoma (ILC) cases in patients 55 to 74 years of age diagnosed between 2000 and 2008 were compared with 902 control women. All participants were interviewed in-person and data on hypercholesterolemia and all episodes of lipid-lowering medication use were collected through a structured questionnaire. We assessed the relationship between statin use and IDC and ILC risk using polytomous logistic regression.
Current users of statins for 10 years or longer had a 1.83-fold increased risk of IDC [95% confidence interval (CI): 1.14-2.93] and a 1.97-fold increased risk of ILC (95% CI: 1.25-3.12) compared with never users of statins. Among women diagnosed with hypercholesterolemia, current users of statins for 10 years or longer had more than double the risk of both IDC (OR: 2.04, 95% CI: 1.17-3.57) and ILC (OR: 2.43, 95% CI: 1.40-4.21) compared with never users.
In this contemporary population-based case-control study, long-term use of statins was associated with increased risks of both IDC and ILC.
Additional studies with similarly high frequencies of statin use for various durations are needed to confirm this novel finding
HuffPost Politics, by Diana Bianchini, September 2010
” All families have secrets. Some stay buried forever. Some rise to the surface with each successive generation. Today as a culture, country (family) and an evolved modern society, we realize that education can stop the conspiracy of silence, generate changes and ultimately lead to learning, healing and forgiveness. When secrets are revealed, apologies need to happen. ”