FACSaware aims to raising global awareness of Fetal Anti Convulsant Syndromes and other Teratogen related syndromes. The Fetal AntiConvulsant Trust (F.A.C.T.) was set up in 2011 to campaign for responsibility from the government and drug company.
Chicks are “vaccinated” as soon as their eggs are laid and before they even hatch
Today, large-scale poultry production has precious little to do with green fields and ruddy-cheeked farmers. Every year, more than 40 billion chickens are slaughtered worldwide for meat, the vast majority of them intensively factory-farmed.
They are often also dosed up with antibiotics — a preventative measure that is easier and cheaper than dealing with individual illnesses at a later date. Now experts are warning that the overuse of antibiotics in poultry farms around the world is creating a generation of superbugs that are resistant to treatment by virtually every drug in the medical establishment’s armoury.
With up to 80 per cent of the raw chicken on sale in some countries carrying these resistant bacteria, they can be transferred to humans during the handling of infected meat or the eating of undercooked produce.
Les résultats sont clairs, le Valproate agit sur l’intelligence des fœtus
Une étude publiée le 16 avril 2009 dans le New England Journal of Medicine conclut que des enfants âgés de trois ans, exposés au Valproate lorsqu’ils étaient dans l’utérus de leur mère, ont des scores de QI neufs points plus faibles que d’autres enfants du même âge exposés à d’autres antiépileptiques.
Il a été démontré que le médicament cause, chez environ 10% des enfants exposés, des défauts congénitaux et ce dès la naissance.
” My name is Theresa and my husband’s name is Matteo.
We have a beautiful little girl named Malia who just had her third birthday.
Matteo and I started trying for a baby when I was 35 years old – once we both finished school, got our careers established and did some of the travelling we both love to do.
Time seemed to fly by and suddenly when I hit my 35th birthday we realized we better get moving on starting our family. ”
DES has terrible side-effects in DES Daughters, DES Sons, DES Grand-Children…
Intrauterine exposure to diethylstilbestrol (DES) has been associated with this subsequent rare development of clear cell adenocarcinoma of the vagina and cervix in exposed female progeny. These tumors have been seen thus far in patients between the ages of 7 and 29 years. In addition, nonmalignant epithelial and structural genital alterations have been frequently observed. The epithelial changes of adenosis, ectropion, metaplasia, and potential neoplasia are considered. Thus far, no increased risk of squamous cell neoplasia has been demonstrated in DES-exposed subjects. However, increased pregnancy wastage, including premature birth, does appear to be more common among DES-exposed women; this increase may be related to the structural uterine and cervical changes that have occurred. DES-exposed men have been demonstrated to have anatomic genital changes, but the effects of these changes, if any, on male infertility are not known. Masculinization of the female external genitalia, including phallic enlargement and labioscrotal fusion, has been reported following intrauterine exposure to certain progestational agents and androgens.
Frozen Embryos ‘More Successful Than Fresh’ For IVF Pregnancies
Frozen embryos are more likely to produce successful, complication-free IVF pregnancies than those that are fresh, research suggests. Using stored embryos cuts the risk of bleeding in pregnancy, premature birth, and giving birth to an underweight baby by almost a third, a study has found.
Does exposure to bisphenol-A (BPA) affect the maturation of human oocytes in vitro?
There was a dose-response association of BPA exposure with altered human oocyte maturation in vitro.
WHAT IS KNOWN ALREADY
There is widespread exposure of the general population to BPA. BPA has been detected in the human follicular fluid. Animal studies have shown that BPA exposure is associated with maturation arrest and spindle abnormalities in maturing oocytes.
STUDY DESIGN, SIZE, DURATION
A randomized trial, using 352 clinically discarded oocytes from 121 patients.
PARTICIPANTS/MATERIALS, SETTING, METHODS
The study population was drawn from patients undergoing IVF/ICSI cycles in our program at Brigham and Women’s Hospital from March 2011 to April 2012. Oocytes from only one cycle for each patient were included in the study. Cycles with at least two germinal vesicle stage oocytes were included with random allocation of one oocyte to culture for 30 h without BPA and remaining sibling oocytes to medium-containing BPA (20, 200 ng/ml or 20 µg/ml). Oocytes were fixed and labeled for tubulin, actin and chromatin and examined with immunofluorescence and confocal microscopy. Oocytes were assessed for meiotic stage (n = 292), and those at metaphase II (MII, n = 175) were further classified according to their spindle configurations and patterns of chromosome alignment. McNemar’s test was used to compare dichotomized maturation status. Generalized estimating equations were used to account for the correlation between oocytes from the same woman and for the spindle analysis.
MAIN RESULTS AND THE ROLE OF CHANCE
As the BPA dose increased, there was a decrease in the percentage of oocytes that progressed to MII (P = 0.002) and increases in the percentage of oocytes that were degenerated (P = 0.01) or that had undergone spontaneous activation (P = 0.007). Among MII oocytes, as the BPA dose increased, there was a significant trend (by test for trend) for a decreased incidence of bipolar spindles (P < 0.0001) and aligned chromosomes (P = 0.02).
LIMITATIONS, REASONS FOR CAUTION
Although we used sibling oocytes to overcome potential confounders, such as infertility diagnosis and maternal age, additional studies with a larger number of oocytes are required to confirm the present results. Having access only to clinically discarded oocytes, we were limited to evaluating only those oocytes that failed to mature in vivo despite having been exposed to gonadotrophin stimulation and the ovulatory trigger of HCG.
WIDER IMPLICATIONS OF THE FINDINGS
To our knowledge, this is the first study investigating the effect of BPA on oocyte meiotic maturation, spindle morphology and chromosome alignment in human oocytes. Together with prior animal studies, the data support the negative influences of BPA on cell cycle progression, spindle architecture and chromosome organization during oocyte maturation. Furthermore, the increased rates of abnormal maturation in oocytes exposed to BPA may be relevant to our understanding of the decrease in fertility reported in the last decades.
The majority of these mothers who said they did not take DES were indeed DES positive by written records…
The written obstetric records of maternal exposure to diethylstilbestrol (DES) were used as a criterion standard and compared with the DES exposure history recalled by mothers of women with vaginal, cervical, or indeterminable vaginal/exocervical clear cell adenocarcinoma.
Among cervical cases, the sensitivity of maternal recall was 50% (N = 2), and its specificity was 100%. Among vaginal and vaginal/exocervical cases, this sensitivity was 72%; specificity was 60%; and the majority of these mothers who said they did not take DES were DES positive by written records.
Thus investigators should avoid using maternal recall alone to measure DES exposure. Among subjects for whom written maternal obstetric records were available, 88% of vaginal cases and 46% of cervical cases were DES positive. The authors conclude that few cases of vaginal clear cell adenocarcinoma should occur in young women as the cohort of women exposed in utero to DES continues to age, whereas cases of cervical origin may continue to occur.