Cervical Screening and general Physical Examination Behaviors of Women exposed to DES

One third of DES-exposed women are not receiving annual Pap smear examinations

DES Follow-up Study Summary

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One third of DES-exposed women are not receiving annual Pap smear examinations.

In this study we evaluated whether women who were exposed in utero to Diethylstilbestrol (DES) follow the recommendations for cervical screening and general physical examinations.

DES-exposed (3140) and unexposed women (826) from the Houston, Boston, Rochester and Los Angeles sites reported on the 1994 questionnaire how frequently over the preceding five years (1990-1994) they had Papanicolau (Pap) smears and general physical examinations.

The study found that DES-exposed women exceeded the recommended frequency of Pap smear screenings compared to unexposed women. The DES exposed women also exceeded the annual recommendations for physical examinations among women without a history of chronic disease when compared to unexposed women. Whereas most DES-exposed women are receiving cervical cancer screening at recommended intervals, a third are not having these annual Pap smear examinations.

2008 Study Abstract

Objective:
To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women.

Materials and Methods:
1994 Diethylstilbestrol Adenosis cohort data are used to assess the degree of recommended compliance of cervical screenings found in 3,140 DES-exposed and 826 unexposed women. Participants were enrolled at 4 sites: Houston, Boston, Rochester, and Los Angeles. Logistic regression modeling was used to analyze mailed questionnaire data, which included reported frequency over the preceding 5 years (1990-1994) of Papanicolaou smears and general physical examinations.

Results:
Diethylstilbestrol-exposed women exceeded the recommended frequency of Papanicolaou smear screenings [adjusted odds ratio (aOR) = 2.15, 95% CI (confidence interval) = 1.60-2.88] compared to the unexposed. This association held among those without a history of cervical intraepithelial neoplasia (aOR = 1.88, 95% CI = 1.35-2.62). Diethylstilbestrol-exposed women exceeded annual recommendations for physical examinations (aOR = 2.27, 95% CI = 1.16-4.43) among women without a history of chronic disease when compared to unexposed women.

Conclusions:
Most DES-exposed women are receiving cervical cancer screening at least at recommended intervals, but one third of the women are not receiving annual Papanicolaou smear examinations.

Sources

  • Cervical screening and general physical examination behaviors of women exposed in utero to diethylstilbestrolNCBI, PMID: 18369304, 2008 Apr;12(2):111-7. doi: 10.1097/LGT.0b013e31815ae980.
  • NCI, DES Follow-up Study Published Papers.
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Author: DES Daughter

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.

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