A new research, on a group of women who had a history of miscarriages and difficulties conceiving, suggests that high levels of Bisphenol-A (BPA) – chemical found in many plastics and canned food – might raise the risk of miscarriage up to 80 percent greater – in women prone to that problem or having trouble getting pregnant.
To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk.
Retrospective cohort of prospectively collected serum samples.
Academic fertility center.
Women presenting for early pregnancy monitoring with singleton pregnancies.
Stored serum samples from 4 to 5 weeks’ gestation analyzed for conjugated serum BPA concentrations.
Main Outcome Measure(s)
Live birth, miscarriage, and chromosome content of miscarriage.
With the 115 women included in the study, there were 47 live births and 68 clinical miscarriages (46 aneuploid and 22 euploid). Median conjugated BPA concentrations were higher in the women who had miscarriages than in those who had live births (0.101 vs. 0.075 ng/mL). Women with the highest quartile of conjugated BPA had an increased relative risk of miscarriage (1.83; 95% CI, 1.14–2.96) compared with the women in the lowest quartile. We found a similar increase risk for both euploid and aneuploid miscarriages.
Maternal conjugated BPA was associated with a higher risk of aneuploid and euploid miscarriage in this cohort. The impact of reducing individual exposure on future pregnancy outcomes deserves further study.
- Canned foods, plastic containers and receipts all increase risk of miscarriage for pregnant women, scientists warn
The Independent, 15 Oct 2013.
- Pregnant women warned of 80pc increased risk of miscarriage from food heated in plastic
The Telegraph, 14 Oct 2013.
- BPA Exposure Linked to Higher Rate of Miscarriage
LiveScience, 14 Oct 2013.
- Tags BPA – Endocrine Disruptors – Pesticides – Phthalates.