Significant proportion of boys exhibiting hypospadias in DES GrandSons
Prenatal Diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males.
This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
Quand il faut évaluer la toxicité des médicaments, les humains ne sont pas des rats de 70 kilos ! Il est temps de dépasser le paradigme actuel d’évaluation de la toxicité des médicaments. La première étape serait de supprimer les exigences réglementaires pour des tests sur des animaux et remplacer ces tests par des méthodes scientifiques du 21ème siècle.
Study Clarifies Link Between Fertility Treatments and Neurological Problems In Kids
The effect of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) on the developing human brain is unclear. The objective of this study is to evaluate neurodevelopmental (ND) outcome of children born following these techniques.
This systematic review includes studies which compare a group of children born following IVF/ICSI to children born after natural conception by assessing outcome in terms of neuromotor development, cognition, speech/language and behaviour. Specific attention is paid to the studies’ methodological quality based on study design, attrition, blinding of the assessor, validity of ND tests used, confounders included and group size or power analysis.
Twenty-three out of 59 studies had a good methodological quality including 9 register-based (RB) and 14 controlled studies. RB studies suggested that IVF/ICSI per se does not increase the risk for severe cognitive impairment (i.e. mental retardation) or neuromotor handicaps such as cerebral palsy (CP), the association of IVF/ICSI and CP being brought about by the association of assisted conception with risk factors, like preterm birth. In general, controlled studies of good quality did not report an excess of ND disorders in IVF/ICSI-children. However, the majority of studies followed the children during infancy only, thereby precluding pertinent conclusions on the risk of ND disorders that come to the expression at older ages, such as fine manipulative disability or dyslexia.
A negative effect of assisted conception on the developing human brain is not identified; however, further research of high methodological quality in children beyond pre-school age is needed.
Wolfgang Dekant and 16 others had collaborations with companies and industry trade groups
Wolfgang Dekant, a German scientist critical of the European Union’s plan to regulate chemicals, with extensive financial ties to regulated industries has resigned from a key scientific committee of the European Commission.
Conjugated bisphenol A in maternal serum in relation to miscarriage risk
A new research, on a group of women who had a history of miscarriages and difficulties conceiving, suggests that high levels of Bisphenol-A (BPA) – chemical found in many plastics and canned food – might raise the risk of miscarriage up to 80 percent greater – in women prone to that problem or having trouble getting pregnant.
To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk.
Retrospective cohort of prospectively collected serum samples.
Academic fertility center.
Women presenting for early pregnancy monitoring with singleton pregnancies.
Stored serum samples from 4 to 5 weeks’ gestation analyzed for conjugated serum BPA concentrations.
Main Outcome Measure(s)
Live birth, miscarriage, and chromosome content of miscarriage.
With the 115 women included in the study, there were 47 live births and 68 clinical miscarriages (46 aneuploid and 22 euploid). Median conjugated BPA concentrations were higher in the women who had miscarriages than in those who had live births (0.101 vs. 0.075 ng/mL). Women with the highest quartile of conjugated BPA had an increased relative risk of miscarriage (1.83; 95% CI, 1.14–2.96) compared with the women in the lowest quartile. We found a similar increase risk for both euploid and aneuploid miscarriages.
Maternal conjugated BPA was associated with a higher risk of aneuploid and euploid miscarriage in this cohort. The impact of reducing individual exposure on future pregnancy outcomes deserves further study.
by Jane Kay, feat. Jill Escher “Autism Exposed” interview
” Three years ago, Jill Escher had an epiphany, one that now consumes her waking hours and night time dreams. After prodding her mother for clues from her past, Jill discovered some hidden history: Her mother had sought help conceiving at a fertility clinic. As she grew in her mother’s womb, Jill was bombarded with synthetic hormones and other drugs.
Now Jill Escher‘s dogged quest to unravel why this happened to her children has drawn the attention of scientists, and may ultimately lead to a greater understanding of how prescription drugs — and perhaps chemicals in the environment — may secretly and subtly harm the health of generations to come. ”
Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal exposure are uncertain. We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age.
In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) between October, 1999, and February, 2004, at 25 epilepsy centres in the UK and the USA. Our primary outcome was intelligence quotient (IQ) at 6 years of age (age-6 IQ) in all children, assessed with linear regression adjusted for maternal IQ, antiepileptic drug type, standardised dose, gestational birth age, and use of periconceptional folate. We also assessed multiple cognitive domains and compared findings with outcomes at younger ages. This study is registered with ClinicalTrials.gov, number NCT00021866.
We included 305 mothers and 311 children (six twin pairs) in the primary analysis. 224 children completed 6 years of follow-up (6-year-completer sample). Multivariate analysis of all children showed that age-6 IQ was lower after exposure to valproate (mean 97, 95% CI 94–101) than to carbamazepine (105, 102–108; p=0·0015), lamotrigine (108, 105–110; p=0·0003), or phenytoin (108, 104–112; p=0·0006). Children exposed to valproate did poorly on measures of verbal and memory abilities compared with those exposed to the other antiepileptic drugs and on non-verbal and executive functions compared with lamotrigine (but not carbamazepine or phenytoin). High doses of valproate were negatively associated with IQ (r=−0·56, p<0·0001), verbal ability (r=−0·40, p=0·0045), non-verbal ability (r=−0·42, p=0·0028), memory (r=−0·30, p=0·0434), and executive function (r=−0·42, p=0·0004), but other antiepileptic drugs were not. Age-6 IQ correlated with IQs at younger ages, and IQ improved with age for infants exposed to any antiepileptic drug. Compared with a normative sample (173 [93%] of 187 children), right-handedness was less frequent in children in our study overall (185 [86%] of 215; p=0·0404) and in the lamotrigine (59 [83%] of 71; p=0·0287) and valproate (38 [79%] of 40; p=0·0089) groups. Verbal abilities were worse than non-verbal abilities in children in our study overall and in the lamotrigine and valproate groups. Mean IQs were higher in children exposed to periconceptional folate (108, 95% CI 106–111) than they were in unexposed children (101, 98–104; p=0·0009).
Fetal valproate exposure has dose-dependent associations with reduced cognitive abilities across a range of domains at 6 years of age. Reduced right-handedness and verbal (vs non-verbal) abilities might be attributable to changes in cerebral lateralisation induced by exposure to antiepileptic drugs. The positive association of periconceptional folate with IQ is consistent with other recent studies.
La prévalence de l’autisme se développe trop rapidement pour qu’elle soit une maladie génétique. Au lieu de cela, il est probablement causée par l’exposition du fétus à des substances nocives.
Les causes de l’autisme sont à rechercher dès avant la naissance mais pas en termes de facteurs génétiques. L’exposition de la mère à certaines substances chimiques pourrait expliquer le trouble chez son enfant. A peine créée, Antidote Europe avait déjà montré que des substances très présentes dans notre environnement pouvaient affecter le développement du système nerveux du foetus.