Will DES Action groups succeed in getting DES acknowledged as a risk factor?
The Breast Cancer Risk Assessment Tool is an interactive tool designed by scientists at the National Cancer Institute (NCI) and the National Surgical Adjuvant Breast and Bowel Project (NSABP) to estimate a woman’s risk of developing invasive breast cancer. The tool has been updated for African American women based on the Contraceptive and Reproductive Experiences (CARE) Study, and for Asian and Pacific Islander women in the United States based on the Asian American Breast Cancer Study (AABCS).
How Environmental Pollution Impairs Brain Development — and How to Protect the Brains of the Next Generation
by Philippe Grandjean
Professor and Chair of Environmental Medicine at the University of Southern Denmark and Adjunct Professor of Environmental Health in the Department of Environmental Health at Harvard School of Public Health, Philippe Grandjean has devoted his career to studying how environmental chemicals affect children and their brain development. His studies on mercury triggered an international response that led to a United Nations agreement to control mercury pollution. Philippe Grandjean has studied children in the U.S. and Denmark, in the Faroe Islands, and countries in South America and Asia, and he has published about 500 scientific papers on his findings.
27% increased breast cancer risk in DES-exposed women
2001 Study Abstract
From 1940 through the 1960s, diethylstilbestrol (DES), a synthetic oestrogen, was given to pregnant women to prevent pregnancy complications and losses. Subsequent studies showed increased risks of reproductive tract abnormalities, particularly vaginal adenocarcinoma, in DES-exposed daughters. An increased risk of breast cancer in the DES-exposed mothers was also found in some studies. In this report, we present further follow-up and a combined analysis of two cohorts of women who were exposed to DES during pregnancy. The purpose of our study was to evaluate maternal DES exposure in relation to risk of cancer, particularly tumours with a hormonal aetiology. DES exposure status was determined by a review of medical records of the Mothers Study cohort or clinical trial records of the Dieckmann Study. Poisson regression analyses were used to estimate relative risks (RR) and 95% confidence intervals (CI) for the relationship between DES and cancer occurrence. The study results demonstrated a modest association between DES exposure and breast cancer risk, RR = 1.27 (95% CI = 1.07-1.52). The increased risk was not exacerbated by a family history of breast cancer, or by use of oral contraceptives or hormone replacement therapy. We found no evidence that DES was associated with risk of ovarian, endometrial or other cancer.
Long-term cancer risk in women given diethylstilbestrol (DES) during pregnancy,NCBI, PMID: 11139327, 2001 Jan 5;84(1):126-33. and PMC2363605 2001. doi: 10.1054/bjoc.2000.1521. Full text PDF link.
Valproate should not be used as a first-choice drug in women of childbearing potential
Fetal exposure of animals to antiepileptic drugs at doses lower than those required to produce congenital malformations can produce cognitive and behavioral abnormalities, but cognitive effects of fetal exposure of humans to antiepileptic drugs are uncertain.
Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom. The primary analysis is a comparison of neurodevelopmental outcomes at the age of 6 years after exposure to different antiepileptic drugs in utero. This report focuses on a planned interim analysis of cognitive outcomes in 309 children at 3 years of age.
At 3 years of age, children who had been exposed to valproate in utero had significantly lower IQ scores than those who had been exposed to other antiepileptic drugs. After adjustment for maternal IQ, maternal age, antiepileptic-drug dose, gestational age at birth, and maternal preconception use of folate, the mean IQ was 101 for children exposed to lamotrigine, 99 for those exposed to phenytoin, 98 for those exposed to carbamazepine, and 92 for those exposed to valproate. On average, children exposed to valproate had an IQ score 9 points lower than the score of those exposed to lamotrigine (95% confidence interval [CI], 3.1 to 14.6; P=0.009), 7 points lower than the score of those exposed to phenytoin (95% CI, 0.2 to 14.0; P=0.04), and 6 points lower than the score of those exposed to carbamazepine (95% CI, 0.6 to 12.0; P=0.04). The association between valproate use and IQ was dose dependent. Children’s IQs were significantly related to maternal IQs among children exposed to carbamazepine, lamotrigine, or phenytoin but not among those exposed to valproate.
In utero exposure to valproate, as compared with other commonly used antiepileptic drugs, is associated with an increased risk of impaired cognitive function at 3 years of age. This finding supports a recommendation that valproate not be used as a first-choice drug in women of childbearing potential.
Listen to “Culture of Silence on sex hormone link to cancer“ , a Radio Interview about DES featuring Carol Devine and Dr Jules Black, produced by Annamarie Reyes, April 05th, 2011.
A recording published on SoundCloudDES axareness playlist
Luc Gaudreau et son équipe de biologistes de l’université de Sherbrooke (Québec) vient de mettre en évidence un mécanisme qui explique comment certains pesticides contribuent au développement de la maladie du cancer du sein.
L’étude à l’origine de cette découverte est basée sur environ une vingtaine de pesticides, couramment utilisés en agriculture.
Intended as a message of hope rather than a ‘how to’ book, A Dream Come True is the inspiring story of one woman’s path to motherhood via fertility treatment using a donated embryo.
Kitty Alexander describes the torment of not being able to have a child naturally, the other routes to parenthood she tried and considered and the process of her fertility treatment. She then moves on to describe the joy of pregnancy and birth, and to the way she has told her son the truth about his origins.
A Dream Come True includes the story she wrote for her son in which she explains everything to him. A deeply positive book, the author hopes it will inspire women who, like her, know what it is like to be faced with an unstoppable tide of longing to become a parent.
Help EDC Free Europe let your governments know that we want an EDC Free Future. Show them you are concerned about where EDCs might be lurking by uploading or liking a photo, and they’ll take it to the decision makers.
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Download the arrow with the slogan ‘Is this disrupting me?’
Tell us what’s disrupting you by holding up the slogan pointed at a product or object that you are concerned about and take a photo!
Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland
Herein we describe a protocol to deliver various reagents to the mouse mammary gland via intraductal injections. Localized drug delivery and knock-down of genes within the mammary epithelium has been difficult to achieve due to the lack of appropriate targeting molecules that are independent of developmental stages such as pregnancy and lactation. Herein, we describe a technique for localized delivery of reagents to the mammary gland at any stage in adulthood via intraductal injection into the nipples of mice. The injections can be performed on live mice, under anesthesia, and allow for a non-invasive and localized drug delivery to the mammary gland. Furthermore, the injections can be repeated over several months without damaging the nipple. Vital dyes such as Evans Blue are very helpful to learn the technique. Upon intraductal injection of the blue dye, the entire ductal tree becomes visible to the eye. Furthermore, fluorescently labeled reagents also allow for visualization and distribution within the mammary gland. This technique is adaptable for a variety of compounds including siRNA, chemotherapeutic agents, and small molecules.