American is a nation of pill poppers. Nearly 13 prescriptions were prescribed per man, woman, and child last year. We’re one of only two countries in the world who allow direct-to-consumer Rx advertising; and Rx have slowly grown to be the third highest medical cost. Welcome to the pill nation. Sources and full article on TheNursingBible and Janice_Flahiff on WordPress.
To examine whether induced (stimulating uterine contractions prior to the onset of spontaneous labor) and/or augmented (increasing the strength, duration, or frequency of uterine contractions with spontaneous onset of labor) births are associated with increased odds of autism.
Design, Setting, and Participants
We performed an epidemiological analysis using multivariable logistic regression modeling involving the North Carolina Detailed Birth Record and Education Research databases. The study featured 625 042 live births linked with school records, including more than 5500 children with a documented exceptionality designation for autism.
Induced or augmented births.
Main Outcomes and Measures
Autism as assessed by exceptionality designations in child educational records.
Compared with children born to mothers who received neither labor induction nor augmentation, children born to mothers who were induced and augmented, induced only, or augmented only experienced increased odds of autism after controlling for potential confounders related to socioeconomic status, maternal health, pregnancy-related events and conditions, and birth year. The observed associations between labor induction/augmentation were particularly pronounced in male children.
Conclusions and Relevance
Our work suggests that induction/augmentation during childbirth is associated with increased odds of autism diagnosis in childhood. While these results are interesting, further investigation is needed to differentiate among potential explanations of the association including underlying pregnancy conditions requiring the eventual need to induce/augment, the events of labor and delivery associated with induction/augmentation, and the specific treatments and dosing used to induce/augment labor (eg, exogenous oxytocin and prostaglandins).
Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990-1998) and Education Research (1997-2007) Databases
Women exposed to DES in utero develop abnormalities, including cervicovaginal adenosis that can lead to cancer
Women exposed to diethylstilbestrol (DES) in utero develop abnormalities, including cervicovaginal adenosis that can lead to cancer. We report that transient disruption of developmental signals by DES permanently changes expression of p63, thereby altering the developmental fate of Müllerian duct epithelium. The cell fate of Müllerian epithelium to be columnar (uterine) or squamous (cervicovaginal) is determined by mesenchymal induction during the perinatal period. Cervicovaginal mesenchyme induced p63 in Müllerian duct epithelium and subsequent squamous differentiation. In p63(-/-) mice, cervicovaginal epithelium differentiated into uterine epithelium. Thus, p63 is an identity switch for Müllerian duct epithelium to be cervicovaginal versus uterine. P63 was also essential for uterine squamous metaplasia induced by DES-exposure. DES-exposure from postnatal day 1 to 5 inhibited induction of p63 in cervicovaginal epithelium via epithelial ERalpha. The inhibitory effect of DES was transient, and most cervicovaginal epithelial cells recovered expression of p63 by 2 days after discontinuation of DES-treatment. However, some cervicovaginal epithelial cells failed to express p63, remained columnar and persisted into adulthood as adenosis.
NCBI, PMID: 14998922, Apr 2004 – Full article The Company of Biologists Limited131/7/1639 15 Dec 2003.
Systematic screen of chemotherapeutics in Drosophila stem cell tumors
” In this article we report a large-scale chemical screen in adult Drosophila to find inhibitors of stem-cell–derived tumors. To our surprise, we found that some Food and Drug Administration-approved chemotherapy drugs have the dual property of reducing growth of stem-cell–derived tumors while also stimulating hyperproliferation of their wild-type counterparts. Since hyperproliferation is one of the hallmarks of cancer cells, this side effect could contribute to refueling the growth of the very tumors that these chemotherapeutics are intended to inhibit. We show that this side effect is driven by the evolutionarily conserved Janus kinase-signal transducers and activators of transcription (JAK-STAT) inflammatory pathway, raising the possibility that the JAK-STAT pathway may also be activated in humans who are treated with some chemotherapeutics. ”
BPA and DES exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo
” UT Arlington biochemists say their newly published study brings researchers a step closer to understanding how the commonly used synthetic compound bisphenol-A, or BPA, may promote breast cancer growth.
Researchers saw similar results when they exposed HOTAIR to a synthetic estrogen called diethylstilbestrol (DES). DES has been shown to increase risks of breast cancer and other health problems in women who used it and their daughters. It was formerly used as a hormone replacement and as an attempt to prevent pregnancy complications. ”
The astronomically high health care costs in the United States explained…
You really think that you have a say in how your government functions, think again. This report describes a shocking revolving door system that works beyond our control.
The amount of money spent on lobbying and political contributions by the pharmaceutical industry has continued to increase since.
It is why you can’t pay your medical bills.
And it is happening behind the scenes so you never see it.
This report is a rare glimpse into how we lost our democracy.
Alors que l’actualité a révélé au grand jour des scandales médicamenteux, le docteur Bernard Dalbergue brise la loi du silence. Cet ancien cadre qui a travaillé pour plusieurs laboratoires pharmaceutiques dévoile une des causes de ces drames : le soutien d’experts médicaux rémunérés peut biaiser la politique de santé. Un secret de famille souvent tu. Le jour où il a refusé de jouer le jeu, la carrière du docteur Dalbergue s’est arrêtée net. Son témoignage, sincère et percutant, dresse un constat terrible : obnubilée par un marketing débridé, surfant sur les failles du système de sécurité du médicament, l’industrie perd parfois de vue sa mission principale, soigner. La journaliste Anne-Laure Barret étoffe ce récit d’une enquête où elle revisite le scandale oublié du Vioxx et montre comment le vaccin Gardasil a été recommandé à la population contre l’avis de nombreux spécialistes.
Première partie : témoignage de Bernard DALBERGUE.
Deuxième partie : Deux enquêtes de Anne Laure BARRET sur le Vioxx® et le vaccin Gardasil® (87 pages), 2 produits phares du dernier employeur de B DALBERGUE et qui posent des questions3.