Sign the Petition: Public Inquiry into Disabilities caused by AntiEpileptic Medication in Pregnancy

To: Rt Hon Stephen Dorrell MP, Chair of the Health Select Committee

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Sign the Petition created by Janet Stockley-Pollard @JanetSP1968 on 38 Degrees.

Dear Minister,

We are appealing to you on behalf of the Fetal Anti Convulsant Trust and all people affected by Fetal AntiConvulsant Syndromes.

Please could you request a public Inquiry as to why Sodium Valproate (Epilim) has been given out for over 30yrs and is still being given out to women with Epilepsy and other conditions like Bi-Polar, manic Depression, Persistant Headaches, and many more, when there is a chance that they may want to start a family. There needs to be more awareness of the fact that research shows conclusively that there is a 12% risk of the child having Neuro Developmental Problems, with the highest incidence being of an Autistic Spectrum Disorder, and that the risk increases to 15% if on a second medication.The risk factor then rises to 40% if you take into account all physical and cognitive impairments also. Some physical impairments are so severe the child doesn’t survive into adulthood.

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The Story of Cosmetics

The pervasive use of toxic chemicals in our everyday personal care products, from lipstick to baby shampoo

Hosted by Annie Leonard, the seven-minute film by The Story of Stuff Project reveals the implications for consumer and worker health and the environment, and outlines ways we can move the industry away from hazardous chemicals and towards safer alternatives. The film concludes with a call for viewers to support legislation aimed at ensuring the safety of cosmetics and personal care products.

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Prescribed Drug Spending in Canada: a Record $40 Billion in 2017

Canada’s love affair with prescription meds…

Take an in-depth look at prescribed drug spending in Canada and learn more about how different drug classes contribute to current trends in total public drug spending.

In 2013 : $29.3 Billion

Prescribed Drug Spending in Canada 2012 cover image
Canada’s love affair with prescription meds…

Millions of Canadians buy prescription drugs; we spent a record $30 billion in 2013. But the annual rate of growth that year —2.3%— was one of the lowest in more than two decades. This is due in part to an increase in the use of less-expensive generic drugs as well as government policies that help keep prices low. ”

Key findings
  • More than 40% of prescribed drug spending was paid for by the public sector, totalling more than $12 billion. In the public sector, payers include provincial and federal drug programs and social security funds (such as workers’ compensation boards).
  • Generic drugs account for almost three-quarters of use but less than half of spending in public drug programs.
  • The number of Canadians who are taking more than $10,000 worth of prescription drugs every year is on the rise, because public drug programs are spending more on high-cost drugs.
  • In 2012, high-cost beneficiaries accounted for about 25% of public drug spending, compared with only 15% in 2007.
  • Almost half of these people were taking a high-cost drug used to treat conditions such as rheumatoid arthritis, Crohn’s disease and macular degeneration.
Sources

Secret Toxic Chemicals in Tampons

Toxic chemicals do not belong in feminine products.
Tell Tampax to Detox the Box!

Toxic chemicals don’t belong in Tampons. Period.

toxic chemicals in tampons infographics
Toxic chemicals don’t belong in Tampons. Period.

Tampax: Detox the Box!

Women’s Voices for the Earth November 2013 Chem Fatale report found toxic chemicals commonly used in feminine care products like pads and tampons. ” Unfortunately, because pads and tampons are regulated as “medical devices” and not “personal care products,” companies aren’t required by law to disclose any of the ingredients used in these products. We know that Procter & Gamble, makers of Tampax and Always, uses some toxic fragrance chemicals – and we have a right to know what else they’re using in pads and tampons. ”

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Why Autism is more common in Males

The female brain requires more extreme genetic alterations than does the male brain to produce symptoms of ASD or neurodevelopmental disorders

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Why autism is more common in males: Science Daily analyses A Higher Mutational Burden in Females Supports a “Female Protective Model” in Neurodevelopmental Disorders study

Males are at greater risk for neurodevelopmental disorders, such as autism spectrum disorder, than females, but the underlying reasons have been unclear. A large cohort study provides compelling evidence in support of the ‘female protective model,’ which proposes that females require more extreme genetic mutations than do males to push them over the diagnostic threshold for neurodevelopmental disorders. Researchers found that females diagnosed with a neurodevelopmental disorder or ASD had a greater number of harmful CNVs than did males diagnosed with the same disorder. Moreover, females diagnosed with ASD had a greater number of harmful SNVs than did males with ASD. These findings suggest that the female brain requires more extreme genetic alterations than does the male brain to produce symptoms of ASD or neurodevelopmental disorders.

Abstract

Increased male prevalence has been repeatedly reported in several neurodevelopmental disorders (NDs), leading to the concept of a “female protective model.” We investigated the molecular basis of this sex-based difference in liability and demonstrated an excess of deleterious autosomal copy-number variants (CNVs) in females compared to males (odds ratio [OR] = 1.46, p = 8 × 10−10) in a cohort of 15,585 probands ascertained for NDs. In an independent autism spectrum disorder (ASD) cohort of 762 families, we found a 3-fold increase in deleterious autosomal CNVs (p = 7 × 10−4) and an excess of private deleterious single-nucleotide variants (SNVs) in female compared to male probands (OR = 1.34, p = 0.03). We also showed that the deleteriousness of autosomal SNVs was significantly higher in female probands (p = 0.0006). A similar bias was observed in parents of probands ascertained for NDs. Deleterious CNVs (>400 kb) were maternally inherited more often (up to 64%, p = 10−15) than small CNVs < 400 kb (OR = 1.45, p = 0.0003). In the ASD cohort, increased maternal transmission was also observed for deleterious CNVs and SNVs. Although ASD females showed higher mutational burden and lower cognition, the excess mutational burden remained, even after adjustment for those cognitive differences. These results strongly suggest that females have an increased etiological burden unlinked to rare deleterious variants on the X chromosome. Carefully phenotyped and genotyped cohorts will be required for identifying the symptoms, which show gender-specific liability to mutational burden.

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Nine Swedish women receive uterus transplants

Pregnancy after New Womb, the @UniOfGothenburg Live-Donor Uterus Transplant Project, 2014

Nine women in Sweden have received uterus transplants from living relatives in an experimental fertility project. The patients in this trial headed by Mats Brannstrom of the University of Gothenburg are mostly women in their 30s who had lost their uterus to cancer or were born without one. The series of transplants took off in September 2012, with donors including the mothers and relatives of the recipients. These women will soon try to get pregnant, Brannstrom said in a CBS report.
Video by TomoNews US, Published on 13 Feb 2014.


In this procedure, a radical hysterectomy is performed on the donor to remove the uterus, cervix and surrounding blood vessels, which will then be implanted to ensure adequate blood flow needed to sustain the uterus. Since the transplanted womb is not connected to the recipient’s fallopian tubes through which eggs are released, natural fertilisation cannot occur in the uterus. Instead, mature eggs will be extracted from the recipient and implanted to the uterus after performing in vitro fertilisation. When the uterus recipient has carried the fetus to full term, the baby is delivered by Caesarian section. The uterus recipient needs to remain on an extensive anti-rejection drug regimen, and the uterus is expected to be removed after a maximum of two pregnancies so the women can be taken off the anti-rejection drugs.

Mats has done something amazing and we understand completely why he has taken this route, but we are wary of that approach,” said Dr. Richard Smith, head of the U.K. charity Womb Transplant UK. Smith is trying to raise 500,000 pounds ($823,000) to carry out five operations in Great Britain.

Two uterus transplants in Turkey and Saudi Arabia had failed to produce successful pregnancies. Similar procedures are currently under development in Hungary and the UK..

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UCB Pharma comdamné et Victoire de Sylvie (Procès Distilbène)

Une double victoire pour Sylvie Le Cossec, 2014

image de Sylvie et de son fils
Sylvie Le Cossec auteure de: 
Mon fils n’aura Jamais son bac

La justice a condamné ce jeudi le laboratoire UCB Pharma à indemniser à hauteur de 81 910€ Sylvie Le Cossec, “fille Distilbène”, qui a subi une ablation de l’utérus et deux grossesses pathologiques. Son fils Julien est polyhandicapé. ”

Lisez Sylvie, “fille Distilbène”, sera indemnisée
l’Express, par Claire Hache, 6 mars 2014


Ecoutez l’interview de Sylvie par David Cormier pour Le Télégramme.

Le Distilbène DES, en savoir plus

Continuous Decrease in Semen Concentration of about 2% per Year for 17 Years in France

Fetal exposure to endocrine disruptors can impair reproductive outcomes

Abstract
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European Society of Human Reproduction and Embryology | The world’s reference point in reproductive science and medicine

Study Question
Are temporal trends and values of semen quality parameters in France identifiable in partners of totally infertile women?

Summary Answer
Among a sample of 26 609 partners of totally infertile women undergoing an assisted reproductive technology (ART) procedures in the whole of France over a 17-year period, there was a continuous decrease in semen concentration of about 1.9% per year and a significant decrease in the percentage with morphologically normal forms but no global trend for motility.

What is Known Already
A global decrease in human sperm quality is still debated as geographical differences have been shown, and many criticisms have risen concerning studies with small and biased study populations or inappropriate statistical methodology. However, growing biological, toxicological, experimental and human exposure data support the endocrine disruptors’ hypothesis assuming that fetal exposure to endocrine disruptors could impair reproductive outcomes.

Study Design, Size, Duration
This was a retrospective and descriptive study using data registered by Fivnat, the professional association in charge of statistics for ART in France during the 1989–2005 study period. Data were provided by 126 main ART centres over the whole metropolitan territory. The source population included 154 712 men, aged 18–70, who were partners of couples undergoing their first ART cycle and for whom semen quality indicators (concentration, total motility and percentage of morphologically normal forms), measured on fresh ejaculated semen, were available.

Participants/Materials, Setting, Methods
The study population was 26 609 partners of women who had both tubes either absent or blocked. The temporal trends for each indicator of semen quality were modelled using a generalized additive model that allowed for nonlinear relationships between variables and were adjusted for season and age. In-depth sensitivity analyses included the reiteration of the analysis on data from a second spermiogram available for each man and on another subsample of men diagnosed as fertile. Variables such as centre, technique (standard in vitro fertilization or intra-cytoplasmic sperm injection) and an interaction factor between technique and time were also included in the model.

Main Results and The Role of Chance
There was a significant and continuous decrease in sperm concentration of 32.2% [26.3–36.3] during the study period. Projections indicate that concentration for a 35-year-old man went from an average of 73.6 million/ml [69.0–78.4] in 1989 to 49.9 million/ml [43.5–54.7] in 2005. A significant, but not quantifiable, decrease in the percentage of sperm with morphologically normal forms along the 17-year period was also observed. There was no global trend but a slight, significant increase in total motility between 1994 and 1998 was observed. The results were robust after sensitivity analysis.

Limitations, Reasons for Caution
Socioeconomic status could not be controlled for. Despite universal access to medical services in France, couples undergoing ART are expected to have a higher educational level on average compared with those of the general population. Therefore, the real values in the general population could be slightly lower than those presented and the decrease possibly stronger, as the population study is less likely to smoke or be overweight, two factors known to impair semen quality.

Wider Implications of The Findings
As the men were selected without a priori knowledge regarding their semen quality characteristics, the results are expected to be close to the values in the general French population. The very large sample size and the robustness of the results confer great statistical power and credibility to the results. To our knowledge, it is the first study concluding a severe and general decrease in sperm concentration and morphology at the scale of a whole country over a substantial period. This constitutes a serious public health warning. The link with the environment particularly needs to be determined.

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Psychological Side-Effects of Anti-Depressants Worse than thought

Adverse emotional and interpersonal effects reported while taking antidepressants

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Latest news and insight from University of Liverpool, research-led and at the heart of one of the world’s greatest cities.

The adverse effects of antidepressants may be more frequent than previously reported, and include emotional and interpersonal effects…

” Thoughts of suicide, sexual difficulties and emotional numbness as a result of anti-depressants may be more widespread than previously thought, a University of Liverpool researcher has found. In a survey of 1,829 people who had been prescribed anti-depressants, the researchers found large numbers of people – over half in some cases – reporting on psychological problems due to their medication, which has led to growing concerns about the scale of the problem of over-prescription of these drugs. “

New Drugs Cost A Lot to Create

Pill Nation: Are Americans Over-Medicated?

Prescription drugs are the fastest growing sector of US healthcare costs

Are Americans Over-Medicated?

New Drugs Cost A Lot to Create infographics
Pill Nation: New Drugs Cost A Lot to Create.

New Drugs Cost A Lot to Create

American is a nation of pill poppers. Nearly 13 prescriptions were prescribed per man, woman, and child last year. We’re one of only two countries in the world who allow direct-to-consumer Rx advertising; and Rx have slowly grown to be the third highest medical cost. Welcome to the pill nation.
Sources and full article on TheNursingBible and Janice_Flahiff on WordPress.

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All our posts about AEDsbig pharmaDESdoctorsdrug money,drugsEx Pharma Rx Drug Pusher Confessions – Gwen Olsen, the FDAmedical representativesSSRIsthalidomidevalproate. See more infographics.

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