Ségolène Royal a accueilli et présidé le conseil national sur la transition écologique ce mardi 29 avril. La thématique environnementale à l’ordre du jour, concerne les perturbateurs endocriniens à l’origine de maladies chroniques. Une consultations publiques avait été ouverte sur le sujet. Le CNTE, conseil qui constitue un véritable dialogue environnementale, permet aujourd’hui d’aborder cette problématique et de se concerter sur les solutions envisagées : mobiliser la recherche, expertiser certaines substances, remplacer celles qui sont nocives, former des professionnels et informer les citoyens. Le rôle clé des entreprises a été souligné en matière de santé et d’environnement concernant la recherche et la mise en oeuvre de produit non toxique. Cette stratégie, véritable moteur pour l’innovation, devrait s’inscrire dans une démarche à l’échelle Européenne. Les enjeux sont tant des enjeux sanitaires qu’économiques.
Comprendre les 5 axes de la stratégie nationale sur les perturbateurs endocriniens:
soutenir la recherche pour mieux connaître les perturbateurs endocriniens et leurs effets sur la santé et l’environnement, notamment en finançant des programmes de recherche et en mettant en place une plateforme public-privé qui permettra de réduire les délais des tests sur les substances chimiques ;
développer l’innovation dans l’industrie, en stimulant la mise en œuvre de produits de substitution innovants et non toxiques ;
renforcer l’expertise et lancer dès cette année l’analyse d’au moins huit substances chimiques par an suspectées d’être des perturbateurs endocriniens ;
porter ce sujet majeur de santé publique au niveau européen et faire de la France un pays moteur de la protection de la santé et l’environnement en Europe ;
améliorer l’information des citoyens, dans leur vie quotidienne comme sur les lieux de travail.
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Expected Release: May 06, 2014.
A Healthy Baby Girl is an inter-generational story of one family’s response to an ethical and technological crisis, experienced from their home in Merrick, Long Island. Intimate and humorous, it’s also a searing exploration of what happens when science, marketing, and corporate power enter our deepest family relationships. Judith‘s video diary, A Healthy Baby Girl, was shot over five years and goes beyond loss to document mother-daughter love, family renewal, survival, political awakening, and community activism.
Young patients aged 10 to 24 years who began treatment with higher-than-recommended doses of antidepressants were more than twice as likely to try to harm themselves as those who were initially treated with the same drugs at lower, recommended doses – while there was no such effect found in patients aged 25 to 64 years.
How diethylstilbestrol DES and other endocrine disrupting chemical EDCs affect murine female reproductive tract development and cancer at the molecular level
Growing concerns over endocrine disrupting chemicals (EDCs) and their effects on human fetal development and adult health have promoted research into the underlying molecular mechanisms of endocrine disruption. Gene targeting technology has allowed insight into the genetic pathways governing reproductive tract development and how exposure to EDCs during a critical developmental window can alter reproductive tract development, potentially forming the basis for adult diseases. This review primarily uses Diethylstilbestrol (DES) as a model agent for EDCs and discusses the recent progress elucidating how DES and other EDCs affect murine female reproductive tract development and cancer at the molecular level.
Endocrine disruptors in female reproductive tract development and carcinogenesis, NCBI, PMID: 19709900, 2009 Sep;20(7):357-63. doi: 10.1016/j.tem.2009.03.009. Epub 2009 Aug 25.
Full text – NCBI, PMC2774851 Trends Endocrinol Metab. Sep 2009; 20(7): 357–363.
Promising new approach targets cancer protein to slow tumor growth: a novel DNA fusion vaccine – called TEM1-TT – targeting the blood vessels that keep tumor cells alive
Sometimes a full-on assault is not the best approach when dealing with a powerful enemy. A more effective approach, in the long run, may be to target the support system replenishing the supplies that keep your foe strong and ready for battle. A group of researchers from the Abramson Cancer Center and the Perelman School of Medicine is pursuing this strategy by employing a novel DNA fusion vaccine – called TEM1-TT – to kill cancer, not by attacking tumor cells, but targeting the blood vessels that keep them alive. The vaccine also indirectly creates an immune response to the tumor itself, amplifying the attack by a phenomenon called epitope spreading. In mouse models of three cancer types, tumor formation was delayed or prevented in mice vaccinated with the vaccine. Specifically, they found that the mouse tumors had suppressed growth, decreased tumor vessel formation, and increased infiltration of immune cells into tumors.
Attacking Cancer Indirectly: Penn Researchers Generate Immunity Against Tumor Vessel Protein, Penn Medicine, News_Releases, 25.04./2014
Full study: Tumor endothelial marker 1–specific DNA vaccination targets tumor vasculature, Journal of Clinical Investigation, Volume 124, Issue 4, doi:10.1172/JCI67382, April 1, 2014
Written info for patients: what’s balanced? what’s neutral?
Parents who are facing decisions about life-sustaining treatment for their seriously ill or dying child are supported by their child’s doctors and nurses. They also frequently seek other information sources to help them deal with the medical and ethical questions that arise. This might include written or web-based information. As part of a project involving the development of such a resource to support parents facing difficult decisions, some ethical questions emerged. Should this information be presented in a strictly neutral fashion? Is it problematic if narratives, arguments or perspectives appear to favour stopping over continuing life-sustaining treatment? Similar questions might arise with written materials about decisions for adults, or for other ethically contentious decisions. This paper explores the meaning of ‘balance’ in information provision, focusing particularly on written information about life-sustaining treatment for children. We contrast the norm of non-directiveness in genetic counselling with the shared decision-making model often endorsed in end-of-life care. We review evidence that parents do not find neutrality from medical professionals helpful in discussions. We argue that balance in written information must be understood in the light of the aim of the document, the most common situation in which it will be used, and any existing biases. We conclude with four important strategies for ensuring that non-neutral information is nevertheless ethically appropriate.
Balancing obligations: should written information about life-sustaining treatment be neutral?, NCBI, PMID: 24763219, 2014 Apr 24 doi: 10.1136/medethics-2013-101965.
Excerpts from written information for parents about end-of-life decisions
Neutrality in information provision
Balance in information provision
In favour of the ‘balanced’ approach for counselling about life-sustaining treatment
Concerns about non-neutrality
Inappropriate withdrawal/limitation of treatment
Balancing obligations: should written information about life-sustaining treatment be neutral?, BMJ, medethics-2013-101965, 24 April 2014 doi:10.1136.
A Chinese herb that is safe, easy to use, affordable, and has great promise in cancer treatment
Wormwood is a Chinese herb that is thousands of years old that has applications for malaria and the treatment of cancer. It is safe, easy to use, affordable, and has great promise in the treatment of cancer. Video by DoctorSaputo, published on 26 Jul 2011.
More info and Videos
There are three forms of wormwood extract: artemisinin, artsunate, and artemether. It can be given either orally or by rectal suppository and should be pulsed with several days on and several off if taken by mouth because of intestinal tolerance. It is non-toxic and has been used on over 4000 patients without problems.
The authors describe a 15-year-old girl with small cell carcinoma of the ovary whose maternal grandmother had been taking DES while she was pregnant with the patient’s mother.
This case, while anecdotal, suggests that a transgenerational history of DES exposure should be noted, and that granddaughters with persistent abdominal pain even during childhood may need evaluation for genital tract abnormalities.
Ovarian carcinoma in an adolescent with transgenerational exposure to diethylstilbestrol, NCBI, PMID: 12902917, 2003 Aug;25(8):635-6.
Full text – Clinical and Laboratory Observations Volume 25 – Issue 8, Lippincott Williams & Wilkins, pp 635-636 2003.
Full text – A case of small cell carcinoma of the ovary hypercalcemic variant in a teenager, ScienceDirect, S2211338X12000622 2012.