Why You should Join the [X]PendaPalooza14 Social Event this Weekend #EmpireAvenue #SocialNetworking

If you’re not yet on #EmpireAvenue, [X]Pendapalooza FOURTEEN is this weekend ! It’s a wonderful opportunity to join #EAv, it is a FREE event, it is safe and it is FUN.

EAv started in 2010 when someone very special called Dups launched a new social media platform. Soon Empire Avenue went beyond the value of a real virtual currency, as it became the place to expand, engage, evaluate your Social Networks.

Amongst the years, EAv has been the theatre of many FUN things such as virtual luxury items, mystery and special achievements and the Xbar Vs ZEN battle to name a few…

The outstanding EAv event which stands above all is called [X]PendaPalooza.

banner of [X]PendaPalooza 14
Why You should Join the [X]PendaPalooza 14 Social Event this Weekend #EmpireAvenue #SocialNetworking

[X]PendaPalooza FOURTEEN is this weekend !

  1. If you’re not yet on Empire Avenue, it’s a wonderful opportunity to join EAv => here.
  2. Then, join the community => here.
  3. Get tips on how to use the platform => here.
  4. Look at the generous give-away missions => here.
  5. Leave any comment(s) on this blog post for any question/help needed.

[X]PendaPalooza14 is a FREE event, it is safe and it is FUN.

Related articles from various bloggers
  • Why Should You Join Or Come Back To Empire Avenue, Road2Social, by Erin Boykin.
  • How to Pay it Forward at [X]Pendapalooza, TheSocialMediahat,
    Preparing for [X]Pendapalooza, TheSocialMediahat,
    How To Capitalize on [X]Pendapalooza Gains, TheSocialMediahat,
    all by Tammi Kibler.
  • [X]Pendapalooza Hyper network with folks on Empire Avenue, The7PillarsBook, by Michael Q Todd
  • Empire Avenue’s [X]PendaPalooza upens to limited media fanfare, but lots of grass rooters rooting!, Inventorspot, by Ron Callari.

Mieux connaître votre avis sur l’automédication

Une enquête de l’UPMC Sorbonne Paris

image de l' UPMC - Paris
UPMC – Université Pierre et Marie Curie – 1ère université française en sciences et médecine.

Dans le cadre du Master Marketing de la Santé de l’UPMC et en collaboration avec l’AFIPA, le Germs réalise une enquête afin de mieux connaître votre avis sur l’automédication.

Il n’y a ni bonnes ni mauvaises réponses. Votre collaboration est essentielle pour la réalisation et la poursuite de cette recherche – concernant l’utilisation de médicaments en Francenous vous remercions donc par avance d’y consacrer un peu de votre temps et de votre attention.

Vos réponses seront bien entendu strictement anonymes et votre contribution ne prendra que quelques minutes. ”

Sources et enquête: SurveyMonkey Automedication.

Meet the twelve known Toxic Chemicals that damage our Children’s Brains

Illustration by Jackie Lay for The Atlantic post:
The Toxins That Threaten Our Brains

neurotoxins infographics
Leading scientists recently identified a dozen chemicals as being responsible for widespread neurodevelopmental disabilities, including #autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments.

Leading scientists recently identified a dozen chemicals as being responsible for widespread neurodevelopmental disabilities, including autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments.
But the scope of the chemical dangers in our environment is likely even greater.

In 2006, Dr Philippe Grandjean did a systematic review and identified six industrial chemicals as developmental neurotoxicants:

  • arsenic
  • ethanol
  • lead
  • methylmercury
  • polychlorinated biphenyls PCBs
  • and toluene.

Seven years later, the number of chemicals known to be toxic to children’s developing brains has doubled with these six additional ones:

  • chlorpyrifos,
  • dichlorodiphenyltrichloroethane DDT/DDE,
  • fluoride,
  • manganese,
  • tetrachloroethylene PERC,
  • and the polybrominated diphenyl ethers PBDEs.

Dr Philippe Grandjean – who wrote the book Only One Chance, how to protect the Brains of the Next Generation – assumes that even more neurotoxicants remain undiscovered and proposes a global prevention strategy.

Sources and Press Articles:
  • The Toxins That Threaten Our Brains, The Atlantic 284466, by James Hamblin, MARCH 18, 2014.
  • Neurobehavioural effects of developmental toxicity, NCBI, PMID: 24556010, 2014 Feb 17.
  • Full text: The Lancet Neurology, Volume 13, Issue 3, Pages 330 – 338, March 2014, doi:10.1016/S1474-4422(13)70278-3
  • More Toxic Chemicals Damaging Children’s Brains, HuffingtonPost, n_4790229, by Lynne Peeples, 02/14/2014
  • Putting the next generation of brains in danger, CNNchemicals-children-brains, by Saundra Young, February 17, 2014

Choosing and taking Vitamins and Mineral Supplements can be incredibly confusing

Will someone tell Judith Potts which vitamin pills actually work?

image of Judith Potts
Judith Potts says she is paying for something about which there is little published evidence of effectiveness. Will someone tell her which vitamin pills actually work?

” … Iron and Calcium should not be taken together because Calcium inhibits absorption of the Iron. Calcium should be taken in the evening because it is best utilised at night and Iron should be taken in the morning on an empty stomach. Zinc should not be taken with Calcium or Iron but must be taken in the afternoon. Vitamin D (which is much in the news) works best if taken with a meal in the early afternoon – because this avoids its “negative influences on sleep” and the same applies to Co-enzyme Q10. Vitamin K should be taken with vitamins D and C plus Calcium and these should be taken with dietary fats – ie milk with cereal, nuts, yoghurt and avocado. Vitamin C only lasts a few hours in the body and, therefore, the doses need to be split throughout the day … ”

Read Will someone tell me which vitamin pills actually work?
The Telegraph, Health and lifestyle 100259778
by Judith PottsFebruary 18th, 2014.

Proliferative Lesions and Reproductive Tract Tumors in Male Descendants of Mice exposed to DES

Increased incidence of proliferative lesions of the rete testis and tumors of the reproductive tract observed in DES lineage mice, apparently transmitted to subsequent generations

Abstract

image of PubMed NCBI The Endocrine Society logo
Increased susceptibility to tumor formation is apparently transmitted to subsequent generation.

Prenatal exposure to Diethylstilbestrol (DES) is associated with reproductive tract abnormalities,  subfertility and neoplasia in experimental animals and humans. Studies using experimental animals suggest that the carcinogenic effects of DES may be transmitted to succeeding generations. To further evaluate this possibility and to determine if there is a sensitive window of exposure, outbred CD-1 mice were treated with DES during three developmental stages: group 1 was treated on days 9-16 of gestation (2.5, 5 or 10 microg/kg maternal body weight) during major organogenesis; group II was treated once on day 18 of gestation (1000 microg/kg maternal body weight) just prior to birth; and group III was treated on days 1-5 of neonatal life (0.002 microg/pup/day). DES-exposed female mice (F(1)) were raised to maturity and bred to control males to generate DES-lineage (F(2)) descendants. The F(2) males obtained from these matings are the subjects of this report; results in F(2) females have been reported previously [Newbold et al. (1998) CARCINOGENESIS:, 19, 1655-1663]. Reproductive performance of F(2) males when bred to control females was not different from control males. However, in DES F(2) males killed at 17-24 months, an increased incidence of proliferative lesions of the rete testis and tumors of the reproductive tract was observed. Since these increases were seen in all DES treatment groups, all exposure periods were considered susceptible to perturbation by DES. These data suggest that, while fertility of the DES F(2) mice appeared unaltered, increased susceptibility for tumors is transmitted from the DES ‘grandmothers’ to subsequent generations.

Sources:
  • Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol, NCBI, PMID: 10874014, 2000 Jul;21(7):1355-63.
  • Full text – Carcinogenesis Volume 21, Issue 7Pp. 1355-1363, OxfordJournals, 21/7/1355.long 2000.
More DES DiEthylStilbestrol Resources

BigPharma: Le contexte international du marché du médicament

Lisez Politiques mondiales du médicament : la régulation indésirable, une édifiante histoire canadienne, par Claudina Michal Teitelbaum pour le Blog du Docteurdu16

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Touvez de la médecine générale sur Docteurdu16.Blogspot.Fr
La médecine générale est une spécialité non enseignée, non publiée (ou presque) et elle souffre d’un manque de reconnaissance lié à son manque d’ambitions éditoriales.

” … C’est dans cette province que s’est produite une attaque sévère et sournoise aux politiques de régulation du marché du médicament, mettant potentiellement en danger la santé et la sécurité des citoyens… … Parmi les tactiques mises en oeuvre par Big Pharma pour s’opposer à la diffusion des génériques, nous pouvons citer:

  • Négociations menées au sein de l’Organisation Mondiale du Commerce lors des cycles de négociations internationales.
  • Demandes d’autorisation de mise sur le marché pour des médicaments de marque brevetés proches de médicaments de référence déjà existants, n’apportant pas d’amélioration significative au plan thérapeutique.
  • Elargissement des patients – via façonnage de maladies – et donc du marché.
  • Développement de marchés de l’espoir – de la dernière chance face à des maladies graves pour lesquelles on ne dispose pas de traitement efficace.

Lisez Politiques mondiales du médicament : la régulation indésirable, une édifiante histoire canadienne, par Claudina Michal Teitelbaum pour le Blog du docdu16.

How the Plastic Particles in Your Food and Water are killing You

BPA and EDCs are associated with many health issues

Aaron Dykes hosts a segment on Bisphenol A, the dangerous estrogenic in plastic drinking bottles and food containers. BPA is a known toxic substance outlawed in Canada and Europe, but still used in the United States, even though the FDA raised concerns regarding exposure of fetuses, infants and young children to the substance.

More information

Pregnant Women who take Antibiotics could be putting their unborn Children at Risk of Disease

When you interrupt the pattern of colonization, you make the babies more susceptible to infection

The Children's Hospital of Philadelphia logo
The Children’s Hospital of Philadelphia is one of the leading pediatric hospitals and research facilities in the world.

Babies who are born preterm, in addition to them having less ability to fight infection, are more likely to get infected, either as a consequence of being born premature or exposure to microbes from the mother’s womb…

By adulthood, a community of a hundred trillion microbes form along a person’s gastrointestinal tract, but at birth, the gut is sterile. Microbial colonization of the gut starts upon an infant’s arrival into the world, initiating an immune response…

Pregnant women who take antibiotics could be putting their unborn children at risk of disease. When you interrupt the pattern of colonization, either by giving antibiotics or some other mechanism, you make the babies more susceptible to infection ..”

Sources:
  • Going With the Gut to Build Preterm Infants’ Immunity, The Children’s Hospital of Philadelphia, Blog, 21 Apr 2014
  • New Study of Gut Microbes, Antibiotics Offers Clues to Improving Immunity in Premature Infants, PRWEB, 11781673, 21 Apr 2014
  • The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice, Nature Medecine, doi:10.1038/nm.3542, 20 April 2014
  • Antibiotics in pregnancy may harm a baby’s immune system by killing the germs that will help make it stronger, DailyMail, health/article-2609737, 22 Apr 2014

Increased Tumors in the Female Descendants of Mice exposed developmentally to DiEthylStilbestrol

An increased incidence of malignant reproductive tract tumors, including uterine adenocarcinoma, was seen in DES lineage mice, apparently transmitted to subsequent generations

Abstract

image of PubMed NCBI The Endocrine Society logo
Increased susceptibility to tumor formation is apparently transmitted to subsequent generation.

Prenatal exposure to Diethylstilbestrol (DES) has been associated with the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia, in experimental animals and humans. Experimental animal studies with chemical carcinogens have raised the possibility that adverse effects of DES may be transmitted to succeeding generations. To evaluate this possibility and to determine if there is a sensitive window of developmental exposure, outbred CD-1 mice were treated with DES during three stages of development: group 1 was treated on days 9-16 of gestation (2.5, 5 or 10 microg/kg maternal body wt), the time of major organogenesis; group II was treated once on day 18 of gestation (1000 microg/kg maternal body wt) just prior to birth; group III was treated on days 1-5 of neonatal life (0.002 microg/pup/day). Female mice (F1) in each group were raised to sexual maturity and bred to control males. As previously reported, fertility of the F1 DES-exposed females was decreased in all groups. Female offspring (DES lineage or F2) from these matings were raised to maturity and housed with control males for 20 weeks. The fertility of these DES lineage female mice was not affected by DES exposure of their ‘grandmothers’. DES lineage mice were killed at 17-19 and 22-24 months of age. An increased incidence of malignant reproductive tract tumors, including uterine adenocarcinoma, was seen in DES lineage mice but not in corresponding controls; the range and prevalence of tumors increased with age. Because uterine adenocarcinomas were seen in all three DES groups, all developmental exposure periods were considered susceptible to the adverse effects of DES. These data suggest that the reduced fertility observed in the DES F1 female mice was not transmitted to their descendants; however, increased susceptibility to tumor formation is apparently transmitted to subsequent generations.

Sources:
  • Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol, NCBI, PMID: 9771938, 1998 Sep;19(9):1655-63.
  • Full text – Carcinogenesis vol.19 no.9 pp.1655–1663, OxfordJournals, 19/9/1655.long 1998.
More DES DiEthylStilbestrol Resources

Isotrétinoine, Roaccutane, grossesses: risque de malformations estimé à 30% chez la femme enceinte

Communiqués ANSM 2002, 2007, 2009

ansm logo
Isotrétinoïne orale: renforcement du Programme de Prévention des Grossesses et rappel sur la survenue éventuelle de troubles psychiatriques par l’ANSM

Les médicaments à base d’isotrétinoine administrés par voie orale sont indiqués dans le traitement de l’acné sévère et de l’acné ayant résisté à un traitement classique d’au moins 3 mois. En raison du risque de malformations chez l’enfant à naître exposé au cours du 1er trimestre de grossesse, l’isotrétinoine est contre-indiquée chez la femme enceinte et, en l’absence de moyen de contraception efficace, chez la femme en âge de procréer. Le risque de malformations est estimé à 30%.

Depuis l’arrêt de la commercialisation de Roaccutane® par les laboratoires Roche, 4 spécialités sont disponibles en France : Curacné® des laboratoires Pierre-Fabre depuis 2002, Procuta® des laboratoires Expanscience depuis 2002, Contracné® des laboratoires Bailleul-Biorga depuis 2005, et Isotrétinoïne Teva® des laboratoires Téva depuis 2008.

L’ANSM rappelle aux médecins prescripteurs :

  • la nécessité absolue de renforcer auprès des patientes en âge de procréer, l’information sur le risque tératogène. Toute prescription d’isotrétinoine doit avoir fait l’objet d’un accord de soins et de contraception signé par chaque patiente. Le médecin doit s’assurer de la bonne compréhension du risque par la patiente
  • avant toute prescription de Roaccutane ou d’un de ses génériques, une brochure d’information, comportant les informations contenues dans la notice de l’AMM, doit être remise à chaque patient, homme ou femme pour préciser les conditions de bon usage de ces médicaments et leurs effets indésirables potentiels.
Communiqués ANSM:
  • Isotrétinoïne orale: renforcement du Programme de Prévention des Grossesses et rappel sur la survenue éventuelle de troubles psychiatriques, ANSM, 28/05/2009
  • Isotrétinoine administrée par voie orale : renforcement des règles de prescription et de délivrance, ANSM, 11/02/2002
  • Isotrétinoïne et effets psychiatriques, ANSM, 22/11/2007
Articles de Presse:
  • Grossesse : trop de femmes s’exposent au danger du Roaccutane, PourquoiDocteur, 10 Avril 2014
  • Médicaments anti-acné : l’ANSM précise les précautions d’usage, PourquoiDocteur, 29 Octobre 2013