Engage in Safe Behaviors – infographic

This National Women’s Health Week, we want to help you take control of your health

National Women’s Health Week 2014 - Schedule Your Well-Woman Visit infographic
Watch @DES_Journal diaporama and health infographics album on Flickr.

National Women’s Health Week is an observance led by the U.S. Department of Health and Human Services Office on womens’s health. The goal is to empower women to make their health a priority. The week also serves as a time to help women understand what steps they can take to improve their health.

What steps can I take for better health?

Female Gene Expression in the Seminal Vesicle of Mice after Prenatal Exposure to Diethylstilbestrol

The seminal vesicle of prenatally DES-exposed male mice acquired two key characteristics of female tissues

Abstract

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The seminal vesicle of prenatally DES-exposed male mice has acquired two key characteristics of female tissues.

Previous studies from our laboratory on the feminization of the male mouse reproductive tract after prenatal exposure to Diethylstilbestrol (DES) showed that the mRNA for the major estrogen-inducible uterine secretory protein, lactoferrin (LF), was constitutively expressed in the seminal vesicle of male mice exposed prenatally to DES, but not in the seminal vesicle of control mice. After castration, treatment with 17 beta-estradiol (20 micrograms/kg.day) for 3 days induced the LF mRNA in the seminal vesicle of both control and prenatally DES-exposed mice; however, the levels in DES-treated tissues were approximately 6-fold higher than those in control tissue. This report describes the presence of LF in seminal vesicle tissues and secretions of prenatally DES-exposed mice, as determined by immunohistochemistry and Western blot analysis. Further, these data are correlated with immunolocalization of the estrogen receptor in the seminal vesicle tissue. We conclude that the seminal vesicle of prenatally DES-exposed male mice has acquired two key characteristics of female tissues, namely LF production/regulation and estrogen receptor localization/distribution similar to that in uterine tissues.

Sources:
  • Female gene expression in the seminal vesicle of mice after prenatal exposure to diethylstilbestrol, NCBI, PMID: 2707167, 1989 May;124(5):2568-76.
More DES DiEthylStilbestrol Resources

Eat Healthy – infographic

This National Women’s Health Week, we want to help you take control of your health

National Women’s Health Week 2014 - Eat Healthy infographic
Watch @DES_Journal diaporama and health infographics album on Flickr.

National Women’s Health Week is an observance led by the U.S. Department of Health and Human Services Office on womens’s health. The goal is to empower women to make their health a priority. The week also serves as a time to help women understand what steps they can take to improve their health.

What steps can I take for better health?

L’industrie pharmaceutique dans le business de maintenir la maladie et de contrôle des symptômes

Big Pharma vu par Peter Moore, 2014

Essayez le plugin ProxTube si cette vidéo est bloquée dans votre pays…

Le Distilbène DES, en savoir plus:

Schedule Your Well-Woman – infographic

This National Women’s Health Week, we want to help you take control of your health

National Women’s Health Week 2014 - Schedule Your Well-Woman Visit infographic
Join the National Women’s Health Week celebration and learn what you can do to lead a healthier life at any age..
What steps can I take for better health?

Pharma Firms have used dangerous Tactics to drive Drugs Sales to treat Children

Pharmaceutical companies in 2008 alone spent nearly $800 million on sales representatives making visits to health care professionals for antipsychotics and antidepressants

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The Denver Post, Colorado’s source for breaking news and information.

Pharmaceutical companies wooed academic leaders, ghostwrote articles, suppressed damaging health data and lavished doctors with gifts to make prescribing powerful psychotropic drugs to children a blockbuster profit center, a trail of lawsuits over the past two decades shows.

  • Lucrative drugs
  • $13 billion paid
  • Off-label uses pushed

Read Drug firms have used dangerous tactics to drive sales to treat kids, The Denver Post Investigations, ci_25561024, 04/14/2014

All our posts tagged BigPharma and DrugMoney.

Pay Attention to Your Mental Health – infographic

This National Women’s Health Week, we want to help you take control of your health

National Women’s Health Week 2014 - Pay Attention to Your Mental Health infographic
click to read @womenshealth stress and your health fact sheet

National Women’s Health Week is an observance led by the U.S. Department of Health and Human Services Office on womens’s health. The goal is to empower women to make their health a priority. The week also serves as a time to help women understand what steps they can take to improve their health.

What steps can I take for better health?

EDCs found in ToothPaste, Soap, Plastic Toys directly impair Human Sperm Function, Male Fertility

Certain endocrine disruptors in household products affect human sperm function and impact fertility

Direct action of endocrine disruptors on human sperm
toothpaste image
Some of these endocrine disrupting chemicals include ultraviolet filters such as 4-methylbenzylidene camphor (4-MBC), which is used in some sunscreens, and Triclosan, an anti-bacterial agent used in toothpaste.

A plethora of endocrine-disrupting chemicals (EDCs) – present in food, textiles, drugs, household, and personal-care products such as plastic bottles, plastic toys, soap, sunscreens, toothpaste and cosmetics – interfere with human sperm function in a way that may have a negative impact on fertilization.
The German – Danish recent research suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that has not been recognized until now.

Sources and press releases:
  • A novel import route for an N‐anchor mitochondrial outer membrane protein aided by the TIM23 complex,
    EMBO Reports, embr.201338142, 29.04.2014
  • Endocrine disruptors impair human sperm function,
    EMBO News, research-news-2014, 12 May 2014
  • Chemicals in soap can cause male infertility, claim scientists,
    The Independent, 9353159, 12 May 2014
  • Sperms’ swimming and navigational skills disrupted by common chemicals, TheGuardian, science/2014/may/12, 12 May 2014
  • Toothpaste, sunscreen chemicals ‘interfere with sperm function’, MedicalNewsToday, articles/276700, 12 May 2014

Get Active – infographic

This National Women’s Health Week, we want to help you take control of your health

National Women’s Health Week 2014 - Get Active
click to read @womenshealth physical activity (exercise) fact sheet

National Women’s Health Week is an observance led by the U.S. Department of Health and Human Services Office on womens’s health. The goal is to empower women to make their health a priority. The week also serves as a time to help women understand what steps they can take to improve their health.

What steps can I take for better health?

The Role of the Estrogen Receptor in DiEthylStilbestrol Toxicity

DiEthylStilbestrol studies – DES can induce neoplastic cell transformation, mutagenesis, irreversible binding to DNA and protein and unscheduled DNA synthesis

Estrogen receptor mechanism in uterine target cell. E represents estradiol but can also be substituted by DES. Cytosolic form ofreceptor (RC); activated cytosol receptor (Rc), nuclear receptor (Rn), progesterone receptor (PRc), glucose 6 phosphate dehydrogenase (G6PD), Korach, 1981.

1985 Study Abstract

The site and specificity of the tissue response to a toxicant are of central importance; it is in this area of Diethylstilbestrol (DES) toxicity that the estrogen receptor would appear to play its primary role. Compilation of the various sites of DES toxicity in humans and experimental animals indicates that lesions appear predominantly in estrogen responsive target tissues suggesting that the presence of the estrogen receptor in such target tissues may help govern the tissue specificity of the toxic insult. DES and many of its oxidative metabolites interact with high affinity with the estrogen receptor. Such an interaction may be responsible for localizing DES to target tissues. Autoradiographic and biochemical studies have supported the localization of radiolabeled DES in susceptible tissues. The intracellular mechanism of receptor binding of DES and certain metabolites could then result in mobilization of these compounds to the nucleus. Experimental evidence has shown that DES and a number of its metabolites are able to translocate receptor to the nucleus of uterine cells. Such an action by the receptor results in an increased probability of potential chemical interactions with the genome. The actual induction of a chemical lesion in the target cell may, at this point, proceed by non-receptor mediated mechanisms. For example, studies using in vitro cell culture systems which contain no estrogen receptors have shown that DES can induce neoplastic cell transformation, mutagenesis, irreversible binding to DNA and protein and unscheduled DNA synthesis. These results raise the possibility that a part of DES toxicity may follow pharmacologic principles established for chemical carcinogens. Following induction of the molecular lesion, the role of the receptor continues in this process by mediating increased protein synthesis and mitogenesis in responsive target tissues which ultimately permits a more extensive expression of the toxic effects. It has been demonstrated that DES is a potent mitogen in vivo in both uterine and pituitary tissues, subsequently, the lesion will perpetuate itself through this receptor mediated biological response. This is particularly important since a number of DES induced reproductive tract tumors are expressed only after additional estrogen exposure. While other tumors have been shown to be estrogen sensitive and will regress without continued estrogen stimulation. Therefore, it should be considered that the presence of the estrogen receptor and the estrogen receptor mediated biological responsiveness of a particular tissue are most important in explaining the specificity of DES toxicity.

Sources:
  • The role of the estrogen receptor in diethylstilbestrol toxicity, NCBI, PMID: 3913404, Arch Toxicol Suppl. 1985;8:33-42.
  • Full study, springer, PDF.
More DES DiEthylStilbestrol Resources