An introduction to Persistent Organic Pollutants POPs

Why they are harmful to human health and the environment

This short animation from IPEN – Working Together for a Toxics-Free Future – provides an introduction to Persistent Organic Pollutants (POPs) and why they are harmful to human health and the environment.

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Cancer is the World’s Biggest Killer

Sign the declaration for a cancer free world!

Cancer is the World's Biggest Killer infographic
Sign Now the World Cancer Declaration : a tool to help bring the growing cancer crisis to the attention of government leaders and health policymakers in order to significantly reduce the global cancer burden by 2025.

This infographic – to download here – was developed to highlight some key figures from the World Cancer Report.
Sign Now the declaration for a cancer free world !

Sources: World Cancer Day 2014 resources.

All our posts tagged cancerinfographicsWorld Cancer Day 2014.

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Bisphenol A Exposure – The More BPA detected in the Women’s Blood, the Higher Risk of Miscarriage

Miscarriage risk rises with BPA exposure, study finds

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Since 2002, Environmental Health News has covered the most important stories on environmental and health issues every day.

Women exposed to high levels of bisphenol-A (BPA) early in their pregnancy had an 83 percent greater risk of miscarriage than women with the lowest levels, according to new research.

The scientists said their new study adds to evidence that low levels of the ubiquitous chemical, used to make polycarbonate plastic and found in some food cans and paper receipts, may affect human reproduction.

The study involved 115 pregnant women who had visited a Stanford University fertility clinic within about four weeks of fertilization. The more BPA detected in the women’s blood, the higher their risk of miscarriage, according to the researchers.

However, the new study doesn’t mean BPA causes miscarriages…   … more women would need to be tested to see if the results are replicated.

Sources
  • Miscarriage risk rises with BPA exposure, study finds, Environmental Health News,
    ehs/news/2014/apr/bpa-miscarriages, April 29, 2014
  • Conjugated bisphenol A (BPA) in maternal serum in relation to miscarriage risk, Fertility and Sterility,
    S0015-0282(14)00265-9, April 17, 2014

Epigenetic Effects of Maternal Nutrition at Conception

Molecular markers of a mother’s nutrition around the time of conception can be found in her child’s DNA

Maternal nutrition around the time of conception can affect the regulatory tagging of her child’s DNA from the earliest embryonic stages, according to a scientific report which focused on a population of women and children in Gambia.

Abstract

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Molecular markers of a mother’s nutrition around the time of conception can be found in her child’s DNA, a study published in Nature Publishing Gp.

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.

Sources
  • Epigenetic Effects of Mom’s Diet,
    The Scientist, articleNo/39841, 29 April 2014
  • Maternal nutrition at conception modulates DNA methylation of human metastable epialleles, Nature Communications, doi:10.1038/ncomms4746, 29 April 2014
  • Supplementary Figures 1-4 and Supplementary Tables 1-4, Nature CommunicationsPDF files

Le cancer, un fléau qui rapporte

Pédiatre, Oncologue, Nicole Delépine dénonce le basculement de notre système de santé

image du livre: le cancer un fléau qui rapporte
Pédiatre, Oncologue, Nicole Delépine dénonce le basculement de notre système de santé.

Alors que la mortalité par cancer ne cessait de diminuer depuis plus de trente ans, le cancer a été déclaré priorité de santé publique dès 1998 et l objet de plans successifs d organisation extrêmement coûteux (1,97 milliard d euros pour le plan 2009-2014). Le coût du cancer s élève environ à 14 milliards d euros annuels pour 350 000 nouveaux patients par an soit 8% des dépenses de santé pour 2% de la population. Les valeurs boursières pharmaceutiques sont devenues valeurs refuges. La mise à disposition très précoce de nouvelles molécules dites innovantes pour 1 milliard d euros annuel échappe au circuit sécurisé habituel du médicament. Vendues à prix d or avant même les résultats des essais thérapeutiques, elles mettent en péril l équilibre de la Sécurité sociale sans bénéfice majeur pour les patients et posent la question du bien-fondé de ces décisions autocratiques au profit de Big Pharma. Et si le système d organisation des soins et de la recherche en cancérologie mis en place depuis 2005 mettait à mal l indépendance professionnelle du médecin, ruinait le colloque singulier médecin/patient, remplaçait la médecine adaptée à chacun par des recettes obligées venues d en haut et appliquées à tous ? La liberté de soigner est essentielle. Sa perte pose non seulement le problème de la qualité des soins mais aussi celui du totalitarisme rampant qui ronge notre société.

Nicole Delépine – auteure de La face cachée des médicaments – dénonce le basculement de notre système de santé dans le capitalisme financier et le despotisme bureaucratique, et explique que la convergence d intérêts politiques et de lobbies médicopharmaceutiques a conduit à une OPA sur le cancer. Dans ce livre de combat, elle appelle solennellement les citoyens à reprendre en mains leur avenir et plus particulièrement dans le domaine de la Santé en luttant avec détermination contre la perversité des conflits d intérêt. ”

En savoir plus

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Check out some cool Phone Apps that could benefit your Health

While there may be some phone apps you can live without, there are some that can keep you healthy!

When it comes to your phone, do you suffer from app overload? While there may be some  phone apps you can live without, there are some that can really help you on your road to staying healthy! Joyce Evans gives us a nice list of things you can use to lose weight, check your pulse, eat right and so much more.

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Long-Term Effects on the Female Mouse Genital Tract associated with Prenatal Exposure to DES

Such prenatal studies with DES in mice may be helpful in understanding the role of estrogens in the functional development of the genital tract

Abstract

The association between treatment of pregnant women with Diethylstilbestrol (DES) and reproductive tract abnormalities in their female offspring is well known.
Reports of comparable in utero exposure in animals are few.

image of PubMed NCBI The Endocrine Society logo
Understanding the role of estrogens in the functional development of the genital tract.

In this paper, pregnant outbred mice were treated s.c. with daily doses of DES ranging from 0.01 to 100 µg/kg on Days 9 to 16 of gestation. This period corresponds with major organogenesis of the reproductive tract in the mouse. Additional groups of pregnant mice were treated during the same time interval with 100-µg/kg doses of either dimethylstilbestrol (DMS), a weakly estrogenic estructural analog of DES, or 17β-estradiol, a potent steroidal estrogen. When female offspring of mice gestationally exposed to DES were sacrificed at 12 to 18 months of age, lesions were found throughout their reproductive tracts. The vagina was characterized by excess keratinization and female hypospadias, and, at the dose of 100 µg/kg, 5 of 20 mice had epidermoid tumors of the vagina; in one of the 35 mice derived from mothers treated with DES (10 µg/kg), vaginal adenocarcinoma was observed. The cervix in the DES-exposed offspring was enlarged, even though the size of its lumen was not different from that in the controls. Stromal stimulation of the cervix was apparent, and a low incidence of benign (leiomyoma, papilloma) as well as malignant (stromal cell sarcoma, leiomyosarcoma) tumors were seen. There was evidence of stimulation in the epithelium, and stroma of the uterus and cystic endometrial hyperplasia was common; a low incidence of benign (leiomyomas) and malignant (adenocarcinoma, stromal cell sarcoma) tumors was observed. The ovaries of prenatally DES-treated females were cystic more often than were those of the corresponding controls; at the highest dose, three ovarian tumors were noted, and the fallopian tubes were inflamed and congenitally malformed. Genital tract tumors were not seen in 85 control females or in the 12 or 10 females exposed prenatally to estradiol or DMS, respectively. In fact, in 12- to 13-month-old females derived from mice exposed during pregnancy to DES (100 µg/kg), common findings, which were absent or in very low incidence in control, estradiol-treated, or DMS-treated mice, included: vaginal concretions and excess keratinization; cervical enlargement; uterine squamous metaplasia and cystic endometrial hyperplasia; and oviductal malformations. The differences in effects among DES, estradiol, and DMS may be linked to differences in relative bioavailability of the compounds to the fetal target tissue.

The results presented suggest a role for different embryonic rudiments as well as for tissue components in the observed long-term effects of gestational exposure to DES on the female reproductive tract. Moreover, such prenatal studies with DES in mice may be helpful in understanding the role of estrogens in the functional development of the genital tract and may ultimately provide a useful experimental model.

Sources:
  • Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol, NCBI, PMID: 7193511, 1980 Nov;40(11):3988-99. Newbold RR.
  • Full text – American Association for Cancer Research, 40/11/3988 Cancer Res, 1980; 40:3988-3999.
More DES DiEthylStilbestrol Resources

Trois décisions concrètes contre les perturbateurs endocriniens

Prévention des risques, Ministère de l’écologie, du développement durable et de l’énergie

Réuni par Ségolène Royal le 29 avril, le Conseil national de la transition écologique a émis un avis favorable sur la stratégie nationale contre les perturbateurs endocriniens et annonçé trois décisions concrètes:

1. Éliminer le bisphénol A des tickets de caisse

logo du Ministere_DD
Trois décisions concrètes contre les perturbateurs endocriniens du Ministère de l’Écologie, du Développement durable et de l’Énergie.

Sans attendre l’issue de cette démarche que la France va entamer au niveau européen pour demander la substitution du Bisphenol-A (BPA) dans les “tickets thermiques” (qui désignent notamment les tickets de caisse et les reçus de carte bancaire) et qui devrait déboucher à la fin 2015, Ségolène Royal souhaite que les entreprises de distribution et grande distribution ainsi que les banques puissent s’engager de façon volontaire dans la suppression du bisphénol A dans leurs tickets, à l’instar de la démarche menée par certains distributeurs précurseurs.

2. Dans les jouets, cibler les contrôles sur les phtalates et accélérer la substitution du bisphénol A

Pour renforcer la protection de la santé des enfants, proposition est faite de cibler les contrôles sur les phtalates dans les jouets, en particulier les jouets importés.
Concernant le bisphénol A, des analyses seront réalisées dans des jouets mis sur le marché français. Il est prévu que la France propose à l’Union européenne de revoir la directive jouets pour substituer totalement le BPA des jouets
Déjà l’an dernier, 7 000 contrôles documentaires ou prélèvements sur les produits chimiques en général ont été menés, dont 800 prélèvements sur des jouets, notamment des jouets importés.

3. Annonce des cinq substances qui seront expertisées en 2014

Concernant les substances qui seront expertisées dès 2014, Ségolène ROYAL a demandé à l’Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail (Anses) de travailler sur 5 substances suspectées d’être perturbateurs endocriniens:

  • le methylparabène, présent dans des produits cosmétiques et produits d’hygiène ;
  • l’acide orthoborique, présent dans les jouets, les adhésifs et lubrifiants (plusieurs dizaines de milliers de tonnes par an sont utilisées dans l’Union européenne) ;
  • le BHA, utilisé notamment dans les produits cosmétiques et les médicaments ;
  • le DINCH et le DEHTP, substances utilisées pour fabriquer des plastiques dans des produits de consommation courante (jouets, articles de puériculture, etc.).

Sources et articles de presse

Pharmaceutical Pinball

Pharmaceuticals destroy your health in the long run. Say no to Big Pharma’s dangerous medications and look to foods, nutrients, herbal remedies and informed lifestyle choices to take care of your health instead

Dan Berger is Cartoonist behind Natural News.

image of Pharmaceutical Pinball
Stop playing pharmaceutical pinball. No matter how much medication you take, you never win. Only the drug companies win, and the longer you play, the more they win (and the more you lose) – @HealthRanger

There’s a pervasive (but false) idea in western medicine that the more pharmaceuticals you take, the healthier you’ll get. That’s how pharmaceuticals are marketed, in fact: Take these pills if you want to be healthier!

… In the real world, the game of pharmaceutical pinball is destroying people’s health and lives. People get put on one drug for one symptom, and then that drug causes three more symptoms. Then the patient goes to the doctor who medicates those three new symptoms with three more drugs. This silly cycle of drug “treatments” leading to yet more side effects continues until the patient either runs out of money or dies from the side effects of the medications (heart attack, liver failure, stroke, etc.)…

Continue reading: Pharmaceutical pinball by Mike Adams, the Health Ranger.

All our posts about big pharma and drugs. See more comics.

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Watch the Diaporama, and the health comics album on  DES Diethylstilbestrol's photostream on Flickr

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Email your photos to des.daughter@gmail.com with a short description and title :-)

MicroRNA-34 and p53 unlocking Mystery of Thalidomide’s Malformation of Limbs

TAU research pinpoints mechanism causing rare and severe congenital syndrome

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Science Daily news unlocking mystery of thalidomide’s malformation of limbs

Shortly after thalidomide was released to market in the 1950s, a reported 10,000 infants were born with an extreme form of a rare congenital syndrome – phocomelia – which caused death in 50 percent of cases.

Researchers from Tel Aviv University’s Sackler Faculty of Medicine have identified a regulator – microRNA (miRNA) miR-34 family – responsible for the malformation of limbs in phocomelia, pinpointing a specific target for possible future intervention.

The study reflects the role that epigenetic regulation plays in the development of disease. Embryonic development can be caused by a genetic mutation or by turning the genes on or off without any change in the genetic code itself.

2014 Study Abstract

The tumor suppressor protein p53 is a powerful regulator of the embryo’s susceptibility to diverse teratogenic stimuli, functioning both as a teratogenesis inducer and suppressor. However, the targets that p53 engages to fulfill its functions remain largely undefined. We asked whether the microRNA (miRNA) miR-34 family, identified as one of the main targets of p53, mediates its function as a teratogenesis inducer. For this, pregnant ICR-, p53- and miR-34a-deficient mice, as well as rats, were exposed to 5-aza-2′-deoxycytidine (5-aza), a teratogen inducing limb reduction anomalies (LRA) of the hindlimbs in mice and either the hindlimbs or forelimbs in rats. Using hind- and forelimb buds of 5-aza-exposed embryos, we identified that the miR-34 family members are the most upregulated miRNAs in mouse and rat limb buds, with their increase level being significantly higher in limb buds destined for LRA. We showed that p53 mediates the 5-aza-induced miR-34 transcription followed by met proto-oncogene and growth-arrest-specific 1 target suppression in embryonic limb buds. We demonstrated that p53 regulates the teratogenic response to 5-aza acting as a teratogenesis inducer albeit miR-34a deletion does not affect the susceptibility of mice to 5-aza. Overall, our study thoroughly characterizes the expression and regulation of miR-34 family in teratogen-resistant and teratogen-sensitive embryonic structures and discusses the involvement of epigenetic miRNA-mediated pathway(s) in induced teratogenesis.

Sources:
  • Unlocking mystery of thalidomide’s malformation of limbsScienceDaily, releases/2014/05/140501111740, 1 May 2014.
  • MicroRNA-34a is dispensable for p53 function as teratogenesis inducer, SpringerLink, Archives of Toxicology, DOI: 10.1007/s00204-014-1223-9, March 2014