Six Dietary Guidelines for Cancer Prevention

The key recommendation is to build meals around fruits, vegetables, and legumes

Six dietary guidelines – for anyone concerned about their cancer risk – are unveiled in the June 30 issue of the Journal of the American College of Nutrition.

Six Dietary Guidelines for Cancer Prevention
The key recommendation is to build meals around fruits, vegetables, and legumes.
  1. Limit dairy products (prostate cancer)
  2. Limit alcohol (cancers of the mouth, pharynx, larynx, esophagus, colon, rectum, and breast)
  3. Limit red and processed meats (cancers of the colon and rectum)
  4. Limit grilled, fried, and broiled meats (cancers of the colon, rectum, breast, prostate, kidney, and pancreas)
  5. Eat more soy products (breast cancer)
  6. Eat more fruits and vegetables (several common forms of cancer)

Read Researchers Unveil Six Dietary Guidelines for Cancer Prevention, Physicians Committee for Responsible Medicine, News Release, June 9, 2014

Let’s keep Nature’s Best Food, Free of Toxic Chemicals

Research finds Round Up chemical in breast milk, what’s next?

Roundup chemical found in breast milk
Round Up chemical in breast milk, what’s next?

Glyphosate Testing Full Report: Findings in American Mothers’ Breast Milk, Urine and Water.

  • Herbicides and water quality & wildlife
  • Public health impacts of residential herbicide use

Research finds Round Up chemical in breast milk, what’s next?

All our posts about breast feeding, EDCs, pesticides, phthalates and SaferChemicals.

On Flickr®

DES Role for Nuclear Receptor Activity in Association with DNA Methylation, Altered Gene Expression

Diethylstilboestrol is a synthetic estrogen associated with adverse effects on reproductive organs

2013 Study Abstract

image of PubMed NCBI The Endocrine Society logo
Diethylstilbestrol DES-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle

BACKGROUND:
Diethylstilboestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes.

OBJECTIVES:
We examined a role for nuclear receptor activity in association with DNA methylation and altered gene expression.

METHODS:
We used the neonatal DES exposure mouse model to examine DNA methylation patterns via bisulfite conversion sequencing in SVs of wild-type (WT) and ERα-knockout (αERKO) mice.

RESULTS:
The DNA methylation status at four specific CpGs (-160, -237, -306, and -367) in the Svs4 gene promoter changed during mouse development from methylated to unmethylated, and DES prevented this change at 10 weeks of age in WT SV. At two specific CpGs (-449 and -459) of the Ltf gene promoter, DES altered the methylation status from methylated to unmethylated. Alterations in DNA methylation of Svs4 and Ltf were not observed in αERKO SVs, suggesting that changes of methylation status at these CpGs are ERα dependent. The methylation status was associated with the level of gene expression. In addition, gene expression of three epigenetic modifiers-DNMT3A, MBD2, and HDAC2-increased in the SV of DES-exposed WT mice.

CONCLUSION:
DES-induced hormonal toxicity resulted from altered gene expression of Svs4 and Ltf associated with changes in DNA methylation that were mediated by ERα. Alterations in gene expression of DNMT3A, MBD2, and HDAC2 in DES-exposed male mice may be involved in mediating the changes in methylation status in the SV.

CITATION:
Li Y, Hamilton KJ, Lai AY, Burns KA, Li L, Wade PA, Korach KS. 2014. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle.

Sources:
  • Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle, NCBI, PMD: 24316720, 2014 Mar;122(3):262-8. doi: 10.1289/ehp.1307351. Epub 2013 Dec 5.
  • Full Text EHP 1307351 Environ Health Perspect; DOI:10.1289/ehp.1307351
More DES DiEthylStilbestrol Resources

Things You might Not know about Miscarriage

Miscarriage is so common, it could happen to you…

Health magazine
Health Magazine and Health.com inspire you to live better and look and feel your best.
  • Your weight matters.
  • Sex doesn’t cause it.
  • It’s not the mother’s fault.
  • Smoking is a known risk factor.
  • You may not know you’ve miscarried.
  • Older women are more likely to miscarry.
  • Fertility treatments may raise your risk.
  • One miscarriage doesn’t mean you’ll have more but also doesn’t mean you’re not going to have another.
  • Miscarriage happens early in pregnancy.
  • Miscarriage happens more often than you think.
  • It’s normal to grieve after a miscarriage.

Read 11 Things You Didn’t Know About Miscarriage,
NewsHealth, News & Views, by Amanda Gardner, June 4, 2014.

Pharmacies vs. Health Food Stores

Dan Berger is Cartoonist behind Natural News

Pharmacies vs. Health Food Stores
Find your local health food store and give them a visit!

Dan Berger is Cartoonist behind Natural News.

The drug industry is constantly trying to convince you that drugs are good for your health while nutritional supplements and healthy foods are somehow bad for you. This same line of nonsense is also repeated by the FDA, which goes out of its way to censor the truth about the healing properties of natural foods like walnuts, cherries and berries

  • The choice is up to you
  • Keeping you ignorant
  • Change your decisions and you’ll change your life

Continue reading: Pharmacies vs. Health Food Stores
by Mike Adams, the Health Ranger.

All our posts about big pharmadrugs, DrugMoney, the FDA.
See more comics

On Flickr®

Watch the Diaporama, and the health comics album on  DES Diethylstilbestrol's photostream on Flickr

If you already have a flickr® account, add us as a contact
Email your photos to des.daughter@gmail.com with a short description and title :-)

#FullMoonEngageMe Social Media Event N°2 – The Strawberry Moon #EAv #SocialNetworking

Friday 13th of June : join our #SocialMedia event taking place at each Full Moon – via #EAv – and give a boost to your social networking! #FullMoonEngageMe #SocialNetworking

Last May, more than 200 people met in the EAv Gangstas community to join the first Full Moon Engage Me Social Media Event.
It was great to read all the positive comments from those happy Empire Avenue players who said “let’s connect” and engage with each other.

The Full Moon Engage Me Social Media Event N°2 Schedule
Strawberry Moon image
Profiles Of Nature, Jerry Goldner, Wildlife Photography © ProfilesOfNature.com

Mea Culpa, in May, I relied on my wall planner icons and mismatched the new moon with the full moon date.
This time I checked better the Full Moon Calendar Dates… and can confirm it will start on Friday 13th of June at 12:00 noon UTC until Monday the 16th in HERE.
The 4 weeks gap between each event will be respected from now on…

The Strawberry Moon

There are native American names for the full moons that you can find here. June Month full moon is called Strawberry Moon!
The picture © above is by Jerry Goldner, during a moonrise over Lake Michigan with untouched moon color.

More information
  • #FullMoonEngageMe SoMe Event – Announcement.
  • #FullMoonEngageMe SoMe Event – Let’s Connect.
  • #FullMoonEngageMe SoMe Event – The FAQs.
  • #FullMoonEngageMe SoMe Event – The Hosts.
  • #FullMoonEngageMe SoMe Event – The Leaders.
  • #FullMoonEngageMe SoMe Event – The Reasons.
  • Please use the comment section to ask any question about the event.
  • You can join – for FREE – Empire Avenue at anytime – before and after any FullMoon EngageMe Social Media Event.
    You can use this link – with no strings attached – to get some extra “eaves” at start !
    See you soon 🙂

Cyborg Babies, from Techno-Sex to Techno-Tots

Includes Living with the “Truths” of DES : Toward an Anthropology of Facts

Cyborg Babies
Includes Living with the “Truths” of DES : Toward an Anthropology of Facts

by Robbie Davis-Floyd and Joseph Dumit

As we are faced with reproductive choices connected directly with technologies, we often have trouble gaining perspective on our own cultural co-dependency with these very same technologies.
Our notions of fetal health, maternal risk and child IQ are inseparable from them.

Chapter 10 includes Living with the “Truths” of DES : Toward an Anthropology of Facts.

On Flickr®
More DES DiEthylStilbestrol Resources

It is Time to Make Clinical Trials Count!

All trials past and present should be registered, and the full methods and the results reported

It is time all clinical trial results are reported. Results from around half of clinical trials have never been published. Information on what was done and what was found in these trials could be lost forever to doctors and researchers, leading to bad treatment decisions, missed opportunities for good medicine, and trials being repeated. The contributions of the hundreds of thousands of patients who took part in those trials remain unused and unusable.

More info and Videos

In Utero Exposure to Antidepressants may Influence Autism Risk

A number of ASD cases might be prevented by reducing SSRI exposure in pregnancy…

Drexel U. News logo
A number of ASD cases might be prevented by reducing SSRI exposure in pregnancy – @DrexelNews logo

A new study from researchers at Drexel University adds evidence that using common antidepressant medications during pregnancy may contribute to a higher risk of autism spectrum disorders (ASD) in children, although this risk is still very small.

A number of ASD cases might be prevented by reducing SSRI exposure in pregnancy…

2014 Study Abstract

We investigated whether there is an association between increased risk for autism spectrum disorders (ASD) and selective serotonin reuptake inhibitors (SSRIs) used during pregnancy. This study used Denmark’s health and population registers to obtain information regarding prescription drugs, ASD diagnosis, and health and socioeconomic status. There were 1.5 % of cases and 0.7 % of controls exposed to SSRIs during the pregnancy period, and higher effect estimates observed with longer use. We found evidence that in utero exposure to SSRIs increases a child’s risk associated with ASD. These results, while adding to the limited knowledge on prenatal pharmacological exposures as potential ASD risk factors, need to be balanced against the benefits of indicated medication use by pregnant mothers.

Sources
  • In Utero Exposure to Antidepressants May Influence Autism Risk, DrexelNow, news-media, June 2, 2014
  • In Utero Exposure to Selective Serotonin Reuptake Inhibitors and Risk for Autism Spectrum Disorder, Springer, Journal of Autism and Developmental Disorders, 10.1007%2Fs10803-014-2128-4

Bisphenol A BPA is a Reproductive Toxicant and has the Potential to affect Male Reproductive System

BPA is a reproductive toxicant because it impacts female reproduction, and has the potential to affect male reproductive systems in humans and animals

Abstract

ehp twitter graphic
EHP Report: BPA is a female reproductive toxicant.

Background:
In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction.

Objective:
This review summarizes the data obtained since 2007, focusing on:

  1. findings from human and animal studies,
  2. the effects of BPA on a variety of reproductive endpoints,
  3. and mechanisms of BPA action.

Methods:
We reviewed the literature using a PubMed search from 2007-2013 based on keywords related to BPA and male and female reproduction.

Discussion:
BPA is an ovarian toxicant because it affects the onset of meiosis in both animal and in vitro models, interferes with germ cell nest breakdown in animal models, accelerates follicle transition in several animal species, alters steroidogenesis in multiple animal models and women, and reduces oocyte quality in animal models and women undergoing IVF. BPA is a uterine toxicant because it impairs uterine endometrial proliferation, decreases uterine receptivity, and increases implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm whether this is the case. BPA is a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, placenta, and pubertal development.

Conclusion:
BPA is a reproductive toxicant because it impacts female reproduction, and has the potential to affect male reproductive systems in humans and animals.

Sources
  • Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013, Environ Health Perspect ; DOI:10.1289/ehp.1307728, 4 June 2014
  • Full text PDF
  • Supplemental Material PDF