The key recommendation is to build meals around fruits, vegetables, and legumes
Six dietary guidelines – for anyone concerned about their cancer risk – are unveiled in the June 30 issue of the Journal of the American College of Nutrition.
The key recommendation is to build meals around fruits, vegetables, and legumes.
Limit dairy products (prostate cancer)
Limit alcohol (cancers of the mouth, pharynx, larynx, esophagus, colon, rectum, and breast)
Limit red and processed meats (cancers of the colon and rectum)
Limit grilled, fried, and broiled meats (cancers of the colon, rectum, breast, prostate, kidney, and pancreas)
Eat more soy products (breast cancer)
Eat more fruits and vegetables (several common forms of cancer)
Read Researchers Unveil Six Dietary Guidelines for Cancer Prevention, Physicians Committee for Responsible Medicine, News Release, June 9, 2014
Diethylstilboestrol is a synthetic estrogen associated with adverse effects on reproductive organs
2013 Study Abstract
Diethylstilbestrol DES-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle
BACKGROUND: Diethylstilboestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes.
OBJECTIVES: We examined a role for nuclear receptor activity in association with DNA methylation and altered gene expression.
METHODS: We used the neonatal DES exposure mouse model to examine DNA methylation patterns via bisulfite conversion sequencing in SVs of wild-type (WT) and ERα-knockout (αERKO) mice.
RESULTS: The DNA methylation status at four specific CpGs (-160, -237, -306, and -367) in the Svs4 gene promoter changed during mouse development from methylated to unmethylated, and DES prevented this change at 10 weeks of age in WT SV. At two specific CpGs (-449 and -459) of the Ltf gene promoter, DES altered the methylation status from methylated to unmethylated. Alterations in DNA methylation of Svs4 and Ltf were not observed in αERKO SVs, suggesting that changes of methylation status at these CpGs are ERα dependent. The methylation status was associated with the level of gene expression. In addition, gene expression of three epigenetic modifiers-DNMT3A, MBD2, and HDAC2-increased in the SV of DES-exposed WT mice.
CONCLUSION: DES-induced hormonal toxicity resulted from altered gene expression of Svs4 and Ltf associated with changes in DNA methylation that were mediated by ERα. Alterations in gene expression of DNMT3A, MBD2, and HDAC2 in DES-exposed male mice may be involved in mediating the changes in methylation status in the SV.
CITATION: Li Y, Hamilton KJ, Lai AY, Burns KA, Li L, Wade PA, Korach KS. 2014. Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle.
Sources:
Diethylstilbestrol (DES)-stimulated hormonal toxicity is mediated by ERα alteration of target gene methylation patterns and epigenetic modifiers (DNMT3A, MBD2, and HDAC2) in the mouse seminal vesicle, NCBI, PMD: 24316720, 2014 Mar;122(3):262-8. doi: 10.1289/ehp.1307351. Epub 2013 Dec 5.
Full Text EHP1307351 Environ Health Perspect; DOI:10.1289/ehp.1307351
The drug industry is constantly trying to convince you that drugs are good for your health while nutritional supplements and healthy foods are somehow bad for you. This same line of nonsense is also repeated by the FDA, which goes out of its way to censor the truth about the healing properties of natural foods like walnuts, cherries and berries
Friday 13th of June : join our #SocialMedia event taking place at each Full Moon – via #EAv – and give a boost to your social networking! #FullMoonEngageMe #SocialNetworking
Mea Culpa, in May, I relied on my wall planner icons and mismatched the new moon with the full moon date. This time I checked better the Full Moon Calendar Dates… and can confirm it will start on Friday 13th of June at 12:00 noon UTC until Monday the 16th in HERE. The 4 weeks gap between each event will be respected from now on…
Please use the comment section to ask any question about the event.
You can join – for FREE – Empire Avenue at anytime – before and after any FullMoon EngageMe Social Media Event. You can use this link – with no strings attached – to get some extra “eaves” at start ! See you soon 🙂
Includes Living with the “Truths” of DES : Toward an Anthropology of Facts
Includes Living with the “Truths” of DES : Toward an Anthropology of Facts
by Robbie Davis-Floyd and Joseph Dumit
As we are faced with reproductive choices connected directly with technologies, we often have trouble gaining perspective on our own cultural co-dependency with these very same technologies. Our notions of fetal health, maternal risk and child IQ are inseparable from them.
Chapter 10 includes Living with the “Truths” of DES : Toward an Anthropology of Facts.
All trials past and present should be registered, and the full methods and the results reported
It is time all clinical trial results are reported. Results from around half of clinical trials have never been published. Information on what was done and what was found in these trials could be lost forever to doctors and researchers, leading to bad treatment decisions, missed opportunities for good medicine, and trials being repeated. The contributions of the hundreds of thousands of patients who took part in those trials remain unused and unusable.
A number of ASD cases might be prevented by reducing SSRI exposure in pregnancy…
A number of ASD cases might be prevented by reducing SSRI exposure in pregnancy – @DrexelNews logo
A new study from researchers at Drexel University adds evidence that using common antidepressant medications during pregnancy may contribute to a higher risk of autism spectrum disorders (ASD) in children, although this risk is still very small.
A number of ASD cases might be prevented by reducing SSRI exposure in pregnancy…
2014 Study Abstract
We investigated whether there is an association between increased risk for autism spectrum disorders (ASD) and selective serotonin reuptake inhibitors (SSRIs) used during pregnancy. This study used Denmark’s health and population registers to obtain information regarding prescription drugs, ASD diagnosis, and health and socioeconomic status. There were 1.5 % of cases and 0.7 % of controls exposed to SSRIs during the pregnancy period, and higher effect estimates observed with longer use. We found evidence that in utero exposure to SSRIs increases a child’s risk associated with ASD. These results, while adding to the limited knowledge on prenatal pharmacological exposures as potential ASD risk factors, need to be balanced against the benefits of indicated medication use by pregnant mothers.
Sources
In Utero Exposure to Antidepressants May Influence Autism Risk, DrexelNow, news-media, June 2, 2014
In Utero Exposure to Selective Serotonin Reuptake Inhibitors and Risk for Autism Spectrum Disorder, Springer, Journal of Autism and Developmental Disorders, 10.1007%2Fs10803-014-2128-4
BPA is a reproductive toxicant because it impacts female reproduction, and has the potential to affect male reproductive systems in humans and animals
Abstract
EHP Report: BPA is a female reproductive toxicant.
Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction.
Objective: This review summarizes the data obtained since 2007, focusing on:
findings from human and animal studies,
the effects of BPA on a variety of reproductive endpoints,
and mechanisms of BPA action.
Methods: We reviewed the literature using a PubMed search from 2007-2013 based on keywords related to BPA and male and female reproduction.
Discussion: BPA is an ovarian toxicant because it affects the onset of meiosis in both animal and in vitro models, interferes with germ cell nest breakdown in animal models, accelerates follicle transition in several animal species, alters steroidogenesis in multiple animal models and women, and reduces oocyte quality in animal models and women undergoing IVF. BPA is a uterine toxicant because it impairs uterine endometrial proliferation, decreases uterine receptivity, and increases implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm whether this is the case. BPA is a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, placenta, and pubertal development.
Conclusion: BPA is a reproductive toxicant because it impacts female reproduction, and has the potential to affect male reproductive systems in humans and animals.
Sources
Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013, Environ Health Perspect ; DOI:10.1289/ehp.1307728, 4 June 2014
