Wild Thyme Plant effective for Breast Cancer Treatment

Effects of Thymus serpyllum extract on cell proliferation, apoptosis and epigenetic events in human breast cancer cells

Thyme has long been known as a medicinal plant.
Oncologist researchers at Celal Bayar University in Turkey carried out a study to determine what effect wild thyme (thymus serpyllum) might have on breast cancer activity. Their 2012 study suggested that thyme might be a serious breast cancer fighter…

Abstract:

Fresh Thyme image
A 2012 study in Turkey suggested that wild thyme might be a serious breast cancer fighter…

Thymus (T.) serpyllum (wild thyme) is an aromatic medicinal plant due to its several biological properties, including anticancer activity. Breast cancer is one of the most common malignancies and increasing evidence supports that it is not only a genetic but also an epigenetic disease. Epigenetics investigates changes in gene expression caused by mechanisms that do not involve alterations in DNA sequence. DNA methylation and histone acetylation are the most widely studied epigenetic changes in cancer cells. This study evaluated the effects of T. serpyllum on apoptosis and epigenetic events in breast cancer cells. XTT cell viability assay was used to determine cytotoxicity. DNA fragmentation and caspase 3/7 activity assays were used in the assesment of apoptosis. DNA methyltransferase (DNMT) and histone deacetylase (HDAC) activities were evaluated by ELISA and verified by qRT-PCR. T. serpyllum extract induced significant cytotoxicity in breast cancer cells (MCF-7 and MDA-MB-231) but not in normal cells. It also induced apoptosis and inhibited the DNMT and HDAC activities in MDA-MB-231 cells. In the present study, the first preliminary data on the effects of the methanolic extract of T. serpyllum in normal and breast cancer cells were obtained and suggest that T. serpyllum may be a promising candidate in the development of novel therapeutic drugs for breast cancer treatment.

Sources:
  • Effects of Thymus serpyllum extract on cell proliferation, apoptosis and epigenetic events in human breast cancer cells,
    NCBI, Nutr Cancer. PMID: 23163852, 64(8):1245-50. doi: 10.1080/01635581.2012.719658, 2012.
  • Thyme: A new breast cancer drug?,
    MotherNatureNetwork, health, Jul 29, 2014.

Author: DES Daughter

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.

Have your say! Share your views

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.