This study illustrates the importance of assessing mixture toxicity of commonly used products whose components have only been evaluated individually
- Tested the reproductive toxicity of a common disinfectant used in many commercial and residential products.
- Disinfectant contained the active ingredients: alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC).
- Mouse breeding pairs were dosed with ADBAC + DDAC at 0, 60 or 120 mg/kg/day in the feed for 6 months.
- Long term exposure decreased fertility and fecundity and caused dam mortality in a dose dependent manner.
- This study highlights the importance of testing the toxicity of mixtures over individual compounds.
Sources and More Information:
- Exposure to common quaternary ammonium disinfectants decreases fertility in mice, Reproductive Toxicology, article/pii/S0890623814001920, DOI: 10.1016/j.reprotox.2014.07.071
- Quats quagmire: Common disinfectants cause reproductive problems in mice, study says, Lindsey Konkel, Environmental Health News, August 13, 2014.