- Your doctor is FAR more likely to kill you than an armed criminal
- Where is the call for “doctor control?”
- Every U.S. hospital is another Sandy Hook
Mike Adams compares deaths by firearms to other causes of death
Mike Adams compares deaths by firearms to other causes of death
This study illustrates the importance of assessing mixture toxicity of commonly used products whose components have only been evaluated individually
2015 video by VitaminDWiki and AmpleEarth
Around 9 out of 10 people you know are deficient in vitamin D, which we get from the sun. Find out why, what that does to you, and what you can do about it, right now by watching this short, stunning animation.
Video published on 24 Apr 2014 by Ample Earth.
This project has the potential to solve problems of micro contaminations in sewage water
The birth control pill is a widespread contraception method. However, large amounts of these modified estrogens leave the body again in urine. The conventional methods in sewage treatment plants are unable to treat this waste water sufficiently because the most frequently used estrogen ethinylestradiol is very difficult to break down. As a result, the hormone finds its way into rivers and lakes and also accumulates in drinking water with serious consequences for fish and other aquatic life. These range from reproductive and severe developmental disorders to the formation of female sexual characteristics in males. The long-term consequences of increasing estrogen pollution for human beings are still largely unknown. Nonetheless, declining sperm counts and thereby increasing infertility in men living in industrial nations may well relate to this hormonal pollution. In addition, testicular and prostate cancers as well as osteoporosis (a reduction in bone density) could be a consequence of overly high concentrations of estrogen in the human body. The goal of the Bielefeld iGEM team is to develop a biological filter in which certain enzymes (so-called laccases) break down the estrogen.
Months of painstaking work in the laboratory at Bielefeld University‘s Center for Biotechnology (CeBiTec) have paid off: the 15 students participating in this year’s ‘international Genetically Engineered Machine competition’ (iGEM) at the Massachusetts Institute of Technology (MIT) have good reason to celebrate. The goal of their project was to develop a biological filter that removes estrogen from drinking water. It was a success: they managed to produce enzymes that break down the hormone. On Monday 5 November, the competition finals came to a close in Boston. From 190 teams throughout the world, Bielefeld’s students made it through to the ‘Sweet Sixteen’, the selection of the 16 best teams in the company of teams from such prestigious universities as Stanford University (USA), the Canadian University of Calgary, and Jiaotong University in Shanghai, China.
More than 70 teams from throughout the world got through to the finals of the top student competition in synthetic biology. The Bielefeld team was one of five German teams at the start. Bielefeld University has now participated in the iGEM competition for the third year running and already succeeded in qualifying for Boston in 2010 and 2011. This year’s team, like its predecessors, made it into the ‘Sweet Sixteen’. ‘We stand in direct comparison with universities like Stanford and Cornell. At first, that seemed very intimidating, but we soon noticed they were having to fight exactly the same problems as we were. And with our know-how, we can match the pace here’, says Moritz Müller, a master student of molecular biotechnology.
Conventional methods of filtering waste water in sewage treatment plants are unable to completely remove medicine residues such as the estrogens in birth control pills. These residues then find their way into rivers and lakes and also accumulate in our drinking water. For fish and other aquatic life, estrogens can lead to reproductive and developmental disorders and even to the formation of female characteristics in males. The potential long-term consequences for human beings – declining sperm counts, infertility, various cancers, and osteoporosis – are still largely unknown.
The Bielefeld iGEM team has developed a biological filter in which specific enzymes (so-called laccases) break down these medicine residues. One known source of particularly efficient laccases is the turkey tail, a type of fungus that grows on trees. Using methods from synthetic biology, the students succeeded in synthesizing this enzyme and applying it to filter material. ‘We didn’t want to invent something totally crazy with our project – just because it’s technically feasible. We wanted to do something that could actually be put to use in the near future, perhaps in 20 years, and be a real benefit’, explains Robert Braun, a master student of molecular biotechnology. ‘The biofilter is such a project. And we have shown that our idea works. In principle, a company could now come along and develop our filter further. We ourselves have got to get back to our studies – most of us have rather neglected them for the last 6 months. However, the experiences we have gathered more than compensate for that’.
The iGEM competition has been held every year since 2003 by the Massachusetts Institute of Technology (MIT) in Boston. Starting as an MIT study course, the number of competitors has grown rapidly from five teams in 2004 to 190 in the present year. All teams face the same task: taking their project from the idea across the laboratory work to gaining funding and communicating the findings. On the student level, the iGEM can be seen as the world championship in synthetic biology that shows the future potential of this still young field of research. The Bielefeld iGEM team is being funded by Bielefeld University‘s Center for Biotechnology (CeBiTec) and the BIO.NRW Cluster Biotechnology North Rhine-Westphalia.
After a year of blood tests, spit tests, Exome sequencing and eventually a trip to Massachusetts General Maya had a diagnosis: ATYPICAL TPP1 DEFICIENCY or SCAR 7
Please help to get this to as many folks as possible.
I am hoping that social networking can help Maya.
For the past year, Maya’s family has been working with doctors to understand Maya “balance issues”.
This past spring, Maya received a diagnosis of Autosomal recessive spinocerebellar ataxia 7 (SCAR7) aka TPP1 Deficiency. SCAR7 is an extremely rare genetic disease. Maya is the 8th reported case in the world. At this stage we are trying to find more people with this disease. Below is a reblog of James’s blog post.
Please give it a read and share it with your network. When we find more people with this disease, then we will be able to get the necessary help from the pharmaceutical and research community.
a blog post by beau james – Saturday, July 26, 2014.
“Loaded for Bear”, definition: To be prepared, mentally and/or physically, for extreme opposition; typically used in reference to an aggressive or potentially violent situation.
Since Maya is the eighth reported SCAR7 case (in the world) she does not “have a community” and science/medicine is slow to catch up to her reality. They consider Maya’s phenotype as “mild”.
I beg to differ… there is nothing “mild” about watching your child slowly lose her ability to walk. To watch your child struggle with her “differences” in school. “Mild” provides little comfort, when she falls, when there is a new scar or when she cries, because she doesn’t understand why her body is revolting against her.
Maya sits between two powerful and mobilized communities in a sort of DMZ. She is between the Batten’s Disease community (a group that is active and hopefully making progress towards meaningful treatment)… read more here and the Ataxia community which appears to believe that SCAR 7 is an ultra-rare disease only occurring in a single Dutch family.
In order to find a cure/help for Maya, we need to find more kids and adults with Maya’s exact phenotype/diagnosis. The more we find, the more science, medicine and the respective communities will pay attention and join the fight.
Ultimately, answers to Maya’s condition will help the Batten’s community (i.e., determining the necessary therapeutic levels of TPP1 replacement enzymes for kids with Battens) and the Ataxia community (i.e., our path to a SCAR7 diagnosis was lucky… I suspect that there are a number of children and adults with Maya’s symptoms (or the natural progression thereof) who are simply un-diagnosed but have TPP1 mutations).
If you are out there, then we need to find you.
BPS is just as potent as BPA in altering brain development and causing hyperactive behavior. It also disrupts heart rhythms, alters cell proliferation leading to cell death…
Currently, no federal agency tests the toxicity of new materials before they are allowed on the market… ! ? ! ?
” … In the current study, the investigators perfused, or flowed, BPS through the arteries of each animal’s pumping heart, after stimulating the heart with the hormone catecholamine to mimic stress. For a control group, 30 rat hearts received only catecholamine and no BPS.
Exposure to BPS rapidly increased the heart rate of female rats and under the stress condition led to arrhythmias—heart rhythm abnormalities—far greater than in the control rats that did not receive BPS, Wang reported. Electocardiograms demonstrated that BPS caused extra heartbeats and a racing heartbeat, also known as ventricular tachycardia. In male rats, BPS reportedly did not have this rapid impact on the heart… ”
” …At the peak time of neuronal birth, the number of neurons in BPA-exposed fish rose 170 percent compared with unexposed fish, Kurrasch stated. In similar experiments using BPS, the number of neurons in exposed fish increased 240 percent. These results, she explained, suggest that BPA and BPS could lead to altered brain connections and might explain the hyperactivity they observed in another experiment. Specifically, the research team used movement tracking software to evaluate behavioral changes in young fish and found that fish exposed during brain development to either BPA or BPS were hyperactive, but unexposed fish were not… ”
Bisphenol-A (BPA) is a well-known endocrine disruptor that imperfectly mimics the effects of physiologic estrogens via membrane-bound estrogen receptors (mERα, mERβ, and GPER/GPR30), thereby initiating nongenomic signaling. Bisphenol S (BPS) is an alternative to BPA in plastic consumer products and thermal paper.
To characterize the nongenomic activities of BPS, we examined signaling pathways it evoked in GH3/B6/F10 rat pituitary cells alone and together with the physiologic estrogen estradiol (E2). Extracellular signal-regulated kinase (ERK)– and c-Jun-N-terminal kinase (JNK)–specific phosphorylations were examined for their correlation to three functional responses: proliferation, caspase activation, and prolactin (PRL) release.
We detected ERK and JNK phosphorylations by fixed-cell immunoassays, identified the predominant mER initiating the signaling with selective inhibitors, estimated cell numbers by crystal violet assays, measured caspase activity by cleavage of fluorescent caspase substrates, and measured PRL release by radioimmunoassay.
BPS phosphoactivated ERK within 2.5 min in a nonmonotonic dose-dependent manner (10–15 to 10–7 M). When combined with 10–9 M E2, the physiologic estrogen’s ERK response was attenuated. BPS could not activate JNK, but it greatly enhanced E2-induced JNK activity. BPS induced cell proliferation at low concentrations (femtomolar to nanomolar), similar to E2. Combinations of both estrogens reduced cell numbers below those of the vehicle control and also activated caspases. Earlier activation of caspase 8 versus caspase 9 demonstrated that BPS initiates apoptosis via the extrinsic pathway, consistent with activation via a membrane receptor. BPS also inhibited rapid (≤ 1 min) E2-induced PRL release.
BPS, once considered a safe substitute for BPA, disrupts membrane-initiated E2-induced cell signaling, leading to altered cell proliferation, cell death, and PRL release.
Chemicals having estrogenic activity (EA) reportedly cause many adverse health effects, especially at low (picomolar to nanomolar) doses in fetal and juvenile mammals.
We sought to determine whether commercially available plastic resins and products, including baby bottles and other products advertised as bisphenol A (BPA) free, release chemicals having EA.
We used a roboticized MCF-7 cell proliferation assay, which is very sensitive, accurate, and repeatable, to quantify the EA of chemicals leached into saline or ethanol extracts of many types of commercially available plastic materials, some exposed to common-use stresses (microwaving, ultraviolet radiation, and/or autoclaving).
Almost all commercially available plastic products we sampled—independent of the type of resin, product, or retail source—leached chemicals having reliably detectable EA, including those advertised as BPA free. In some cases, BPA-free products released chemicals having more EA than did BPA-containing products.
Many plastic products are mischaracterized as being EA free if extracted with only one solvent and not exposed to common-use stresses. However, we can identify existing compounds, or have developed, monomers, additives, or processing agents that have no detectable EA and have similar costs. Hence, our data suggest that EA-free plastic products exposed to common-use stresses and extracted by saline and ethanol solvents could be cost-effectively made on a commercial scale and thereby eliminate a potential health risk posed by most currently available plastic products that leach chemicals having EA into food products.
Women who exercise regularly for four years after the menopause can “rapidly decrease” their risk of breast cancer
“Exercise lowers risk of breast cancer after menopause” reports The Independent. This and similar headlines were sparked by a large study of postmenopausal teachers that found increased recreational activity was associated with a 10% decrease in the risk of breast cancer.
The study used questionnaires to estimate the levels of walking, cycling and sport the women did outside of work. Researchers found that women who exercised vigorously for seven or more hours each week were 25 percent less likely to develop breast cancer, compared to those who exercised less than one hour each week. Examples of vigorous activity include basketball, swimming, running and aerobics. The results were similar if women walked briskly, but there was no benefit for walking at normal pace. The results did not differ by the estrogen receptor status of the breast cancer. It also found that women who did the equivalent of walking at least four hours a week or doing sport for two hours a week had a reduced risk of breast cancer. Factors such as body mass index (BMI) did not change the results.
Pregnant women and fetuses exposed to antibacterial compounds face potential health risks
As the Food and Drug Administration mulls over whether to rein in the use of common antibacterial compounds that are causing growing concern among environmental health experts, scientists are reporting that many pregnant women and their fetuses are being exposed to these substances. The compounds are used in more than 2,000 everyday products marketed as antimicrobial, including toothpastes, soaps, detergents, carpets, paints, school supplies and toys, the researchers say. Pregnant women and fetuses that are exposed to triclosan and triclocarban — two common ingredients found in antibacterial soap — could face health risks.
People in the psychiatric community have definitely known since the 1970s that prenatal exposure to estrogens or progestins causes permanent, lifelong changes in that person’s personality and behaviour…
Thanks to Hugh Easton for this study find and comment:
Here’s a particularly shocking piece of research, which shows that it’s been known since at least the 1970s that prenatal exposure to estrogens and progestins can produce lifelong alterations to peoples’ personality and behaviour. From there, It’s not an enormous leap to them also affecting gender identity!
Seventy-one offspring of mothers administered combinations of synthetic progestins and estrogen for the maintenance of at-risk pregnancy were evaluated for their performance on IQ and personality tests. Siblings born of untreated pregnancies acted as controls. Hormone-exposed subjects were partitioned into three treatment subgroups dependent on the ratio of progestin to estrogen administered to their mothers during pregnancy. No difference in IQ was obtained among the three treatment subgroups even when scores were adjusted for sibling score and prenatal and perinatal complications. Responses to the personality questionnaire provided significant differences among the three groups. The group exposed to the progestin regime (progestin alone or in combination with very low doses of estrogen) and the estrogen regime (higher doses of estrogen than progestin) were most dissimilar. Progestin regime exposed subjects were characterized as more independent, sensitive, self-assured, individualistic, and self-sufficient. In contrast, the subjects exposed to the estrogen regime were more group oriented and group dependent. Analysis of difference scores generated by subtracting the score of an unexposed sibling from that of the exposed cosibling provided similar results. A general discussion is presented on the efficacy of hormone treatment for pregnancy maintenance, augmented fetal wastage of males, birth order and treatment, maternal knowledge of treatment and its possible postnatal effects on the offspring, and drug effects on the fetus.
Guidelines are useful but make sure you know the evidence or lack thereof
A parody song designed to get you thinking about the problem with strictly following (cardiovascular guidelines/target shooting) and NOT using evidence to help you and your patient make decisions. The lab coat logos are from top drug companies, top Rx medications and top guideline producers. Guidelines are useful but make sure you know the evidence or lack thereof.