UterineFibroids : Questions to ask your Surgeon before Fibroid Surgery

What should you do if you need to have fibroids removed?

Here are three questions to ask your surgeon that may help you decide:

Many physicians are still using morcellators and may inadvertently spread undiagnosed cancer…
  • What exactly are you going to do?
  • What are the risks?
  • What do my imaging tests reveal?

Read 3 Questions to Ask Before Fibroid Surgery, NewsHealth, 2014/09/23.

Also checkout some related posts.

Investigating the association between central obesity (using skirt size) and breast cancer risk

Association of skirt size and postmenopausal breast cancer risk in older women: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening

Abstract

The BMJ logo image
Increased breast cancer risk – by a third – for women who go up a skirt size as they get older, study suggests… expanding waistline for women is a warning for higher breast cancer risk..

Objectives
Several studies suggest that overall and central-obesity are associated with increased breast cancer (BC) risk in postmenopausal-women. However, there are no studies investigating changes of central obesity and BC. We report on the association of BC risk with self-reported skirt size (SS; waist-circumference proxy) changes between 20s and postmenopausal-age.

Design
Prospective cohort-study.

Setting
UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) involving the nine trial centres in England.

Participants
Postmenopausal-women aged >50 with no known history of BC prior to or on the day of completion of the study-entry questionnaire.

Interventions
At recruitment and at study entry, women were asked to complete a questionnaire. Women were followed-up via ‘flagging’ at the NHS Information Centre in England and the Hospital Episode Statistics.

Main outcome-measure
Time to initial BC diagnosis.

Results
Between 2 January 2005 and 1 July 2010, 92 834 UKCTOCS participants (median age 64.0) completed the study-entry questionnaire. During median follow-up of 3.19 years (25th–75th centile: 2.46–3.78), 1090 women developed BC. Model adjusted analysis for potential confounders showed body mass index (BMI) at recruitment to UKCTOCS (HR for a 5 unit change=1.076, 95% CI 1.012 to 1.136), current SS at study entry (HR=1.051; 95% CI 1.014 to 1.089) and change in SS per 10 years (CSS) (HR=1.330; 95% CI 1.121 to 1.579) were associated with increased BC risk but not SS at 25 (HR=1.006; 95% CI 0.958 to 1.056). CSS was the most predictive singe adiposity measure and further analysis including both CSS and BMI in the model revealed CSS remained significant (HR=1.266; 95% CI 1.041 to 1.538) but not BMI (HR=1.037; 95% CI 0.970 to 1.109).

Conclusions
CSS is associated with BC risk independent of BMI. A unit increase in UK SS (eg, 12–14) every 10-years between 25 and postmenopausal-age is associated with postmenopausal BC risk by 33%. Validation of these results could provide women with a simple and easy to understand message.

Strengths and limitations of this study

  • To the best of our knowledge, this is the first study investigating the association between central obesity using skirt size (SS) as a proxy and breast cancer risk. Between 25 and postmenopausal age, an increase in SS by one unit every decade increased the risk of postmenopausal breast cancer by 33% while decrease in SS was associated with lowering of risk.
  • Our prospective cohort-study includes 94 000 women with comprehensive follow-up through data linkage to multiple national databases.
  • There is a possibility of underestimation of self-reported SS. However, if current SS at study entry is uniformly underestimated then there is merely rescaling of CSS so that the strength of the association is unaffected. Furthermore, recall bias of the SS at 25 maybe a limitation but unless this inability in reporting is systematically related to future breast cancer, measurement error can only result in underestimating the strength of the true association between CSS and breast cancer risk.
  • Given that obesity is now emerging as a global epidemic, from a public health prospective these findings are significant as they provide women with a simple and easy to understand message.
Sources and More Information:
  • Association of skirt size and postmenopausal breast cancer risk in older women: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), BMJ Open 2014;4:e005400 doi:10.1136/bmjopen-2014-005400, 24.09.2014.
  • Skirt size increase ups breast cancer risk, NHS Choices, Cancer, September 25 2014.

What is Wrong with Mammography Screening for Breast Cancer early Detection?

Are safer methods of breast cancer screening becoming available?

image of mammography screening machine
What is wrong with mammography? Are safer methods of breast cancer screening becoming available?

Even though mammography is the most widely used screening method for breast cancer, there are a number of valid arguments for alternative methods. Research has shown that mammograms are not the definitive answer to early detection, and in fact, can often cause more problems than they solve. So what is wrong with mammography?

  • Mammograms can add to cancer risk
  • High rate of false positive
  • High rate of false negatives
  • Estrogen distorts breast x-rays

Read 4 serious risks & problems with mammograms,
NaturalNews.com, September 24, 2014.

L’affaire Distilbène ou Mutilations sur ordonnances, bande annonce

Dane Morin-Delacroix constate en 1983 que ses quatre enfants sont tous nés avec des lésions et des malformations provoquées par le Distilbène prescrit lors de ses grossesses

Ces écrits relatent les aventures incroyables d’une mère de famille, qui découvre l’effarante réalité : Avec plus de 300 000 femmes elle a absorbé pendant ses grossesses un traitement qui a provoqué des cancers et des malformations sur les enfants qu’elles portaient… pouvant se transmettre aux générations suivantes !

Plus d’informations:

Le Distilbène DES, en savoir plus

DES medical/legal implications of its long-term sequelae, including third generation effects

Diethylstilbestrol, teratogenesis, and carcinogenesis: medical/legal implications of its long-term sequelae, including third generation effects

1990 Study Abstract:

image of PubMed NCBI The Endocrine Society logo
DiEthylStilbestrol usage review buttress the need for adequate and rigorous research into the use of drugs in pregnancy and ensure that they do more good than harm before being introduced.

The spectrum of teratogenic and carcinogenic effects which can be exerted when the unborn child is exposed to diethylstilbestrol (DES) has been shown to be broad. Animal work indicates the need for vigilance as regards genetic susceptibility to DES sequelae. The emergence of third generation sequelae has been demonstrated in mice, and has been postulated to occur in humans. Given the emergent data establishing problems of infertility in men and women and of relatively late onset cancer, and the possibility that in utero exposure to DES may prime a variety of tissues to noxious environmental influences there is an urgent need for measures to provide just coverage for those harmed by the drug. The DES disaster also raises important ethical and reserch questions which demand attention.

Sources

  • Diethylstilbestrol, teratogenesis, and carcinogenesis: medical/legal implications of its long-term sequelae, including third generation effects, NCBI, PMID: 23511655, 1990;1(3):171-93. doi: 10.3233/JRS-1990-1301.
More DES DiEthylStilbestrol Resources

Deadly Medicine: Laparoscopic Power Morcellation

A Common Surgery for Women and the Cancer it Leaves Behind

Deadly Medicine ebook cover image
Download this free WSJ ebook.

Since the 1990s, thousands of women have undertaken a surgical procedure that may have risked their lives.

After Dr. Amy Reed had surgery to remove uterine fibroids, involving a procedure known as power morcellation, she learned that it had worsened her prognosis by spreading a cancer she and her doctors didn’t know she had.

Dr. Reed became a vocal critic of power morcellators and the doctors who used them, dividing the medical community. Now doctors and companies are waiting for more-permanent guidance from the FDA.

This story, drawn from ongoing coverage in The Wall Street Journal, is a gripping human-interest account of public trust and the fallibility of modern medicine. ”

Dr. Noorchashm campaign against hysterectomy using electric power morcellation
  • Public testimony gets heated at FDA panel meeting on morcellation, OBGYNNews, video, JULY 11, 2014.
  • Health Alert: Many Women Have Died Because Deadly Cancers of the Uterus Are Being Spread by Gynecologists. Stop Morcellation of the Uterus in Minimally Invasive Surgery,
    Change, SIGN the Petition by Hooman Noorchashm.

Phthalates and Young Girls Exposure

Puberty comes earlier for Girls, thanks to EDCs and Phthalates Exposure

Phthalates Campaign for Safe Cosmetics
Get Involved! Sources: Campaign for Safe Cosmetics on Facebook.

About Half of Cancers are caught too late in England

Analysis of the financial implications of achieving earlier diagnosis of colorectal, lung and ovarian cancer

Cancer Research UK logo image
Half of cancers in England diagnosed at late stage as a report prepared for Cancer Research UK shows that early diagnosis saves lives and could save the NHS millions of pounds.

A Cancer Research UK analysis out today reveals that 46 per cent of cancers in England are diagnosed at an advanced stage, when they are harder to treat successfully.

The figures come as a new report shows that if all areas diagnosed cancers as early as the best in England, for four types of cancer alone, this could save the NHS over £44 million in treatment costs and benefit over 11,000 patients each year. Extrapolating this to all types of cancer would imply an annual saving of nearly £210m, while helping to improve the survival prospects for more than 52,000 patients. ”

Sources and More Information:

  • Half of cancers diagnosed at late stage as report shows early diagnosis saves lives and could save the NHS money, CancerResearchUK, Press release, 22 September 2014.
  • Saving lives, averting costs,
    A report prepared for Cancer Research UK, September 2014.
  • Late cancer diagnosis ‘costing lives and money’, NHS Choices, cancer, September 22 2014.

Are Clinical Trials important? What do they involve?

A clinical trial is a particular type of clinical research that compares one treatment with another. It may involve patients or healthy people, or both

In this video, EFPIA Director General Richard Bergström explains why clinical trials are important, what they involve.

Sources and more information

Stilbosol

Stilbosol patenting turned the cattle feed industry upside down in the mid fifties with its phenomenal use by the farmers and feeders

image of Stilbosol-Wise-Burroughs
Wise Burroughs – image credit Iowa State University of Science and Technology.

… ” One of the most important and far-reaching events in the department in the early 1950s was the patenting of defined levels of diethylstilbestrol (DES), a growth-promoting hormone, to feed beef cattle for improved growth and efficiency.

The saga includes how Wise Burroughs found that quality clover hay contained estrogens that enhanced growth, and how he, by studying the literature on DES, determined the levels to produce the desired effects, but not the negative ones. The work with the Iowa State College Research Foundation to secure the patent, the feud with colleagues at Ames and Purdue, the announcement at Cattle Feeder’s Day in 1954 that turned the feed industry upside down, the struggle to secure FDA approval, the involvement of President Hilton in the licensing done with Lilly, and the phenomenal use of Stilbosol by the feeders make a story worthy of the book about it by A.I. Marcus in 1994. The events changed the way new technology was utilized and controlled by the Food and Drug Adminstration. Eventually DES was banned in 1979. A portion of the proceeds from the patent built Lush Auditorium, and the use of DES enhanced the profitability of cattle feeding. ” …

Sources and more information
  • Elanco history, elanco.com.
  • Modern Meat: Synthetic Hormones, Livestock, and Consumers in the Post-WWII Era, Yale.edu.
  • History of diethylstilbestrol use in cattle, asas.org, 2002.
  • History of Animal Science Department, ans.iastate.edu, 2000.
  • History of Hormonal Modifier Use, beefextension.com, 1997.
Related books
More DES DiEthylStilbestrol Resources