Hacking the Brain with Prescription Drugs

Middle-schoolers are using the prescription drugs more and more

hacking-the-brain Infographic
Watch our selection of infographics addressing health issues on Flickr.

Neurological Enhancements

… ” After studying this infographic I was not surprised to see that most brain-hacking drug users remain in the education industry. Scientists, professors and researchers use these drugs to have an edge above their competitors or to keep up with the work load. ” …

Read Hacking the Brain with Prescription Drugs
on DailyInfographic, Oct 26, 2012.

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On Flickr®

Maternal BPA programs Offspring Metabolic Syndrome

By the Collaborative on Health and the Environment

Prenatal exposure to EDCs, specifically the plastic component BPA, can increase the relative risk of adult obesity and metabolic syndrome.

On this call Drs. Ross and Desai presented evidence that prenatal exposure to endocrine disrupting chemicals (EDCs), specifically the plastic component bisphenol A, can increase the relative risk of adult obesity and metabolic syndrome.
They also discussed the significance of these findings for neonatal and childhood care, and the need for strategies for the prevention and therapy of obesity to address programming effects of the early life environment.

Sources:

Vaccin contre le cancer du col de l’utérus: fausse santé publique?

Le médecin ne conseille plus mais impose des examens et des traitements sous contrôle des labos – Professeur Henri Joyeux

image of Pr. Henri Joyeux
Pr. Henri Joyeux, Chirurgien Cancérologue.

Vaccin contre cancer du col de l’utérus: faire courir un risque à nos enfants?

Vaccin contre le cancer du col de l’utérus : Rendre obligatoire ce vaccin dès l’âge de 9 ans, aux frais de l’assurance maladie pour 65%, et des parents que l’on saura harceler pour la santé de leurs enfants est un objectif de “fausse santé publique”.

  • Une forte publicité auprès des médecins pour prouver l’efficacité et vacciner – “le plus tôt sera le mieux” – et un bourrage de crâne à destination de toutes les mères de famille
  • Les complications de la vaccination contre les HPV
  • Qui doit être vacciné et existe-t-il des alternatives à la vaccination?

Lisez Le (futur) scandale des vaccins contre le cancer du col de l’utérus, professeur-joyeux.com, 19.09.2014.

The War on Cancer begins with You

Cancer, perhaps the biggest stymie to modern medicine, is also preventable in most cases. This is good news depending on how you look at it…

The war on Cancer begins with you Infographic
Watch our selection of infographics addressing health issues on Flickr.

Cholera, diarrhea, tuberculosis – some of the most deadly diseases to plague the human race throughout history are all preventable in some way. Cancer, perhaps the biggest stymie to modern medicine, is also preventable in most cases. This is good news depending on how you look at it.” …

… continue reading The Good News about Cancer
by Erich Scholl, dailyinfographic, MARCH 19, 2014.

See more infographics and posts tagged cancer.

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What Normal Feels Like

#WhatNormalFeelsLike Breast Cancer Awareness Campaign by @CoppaFeelPeople

Campaign uses naked breasts to ask UK women #whatnormalfeelslike for them

Coppa Feel new advertising campaign image
How are you ever going to spot any changes in your boobs if you’ve never taken the time to get to know #WhatNormalFeelsLike.

We’re very excited to launch our new advertising campaign today, featuring seven bare-chested ladies, taken by legendary photographer Rankin!

Their boobs are painted with words that best describe #whatnormalfeelslike for them. We want you ladies to reclaim the vocabulary surrounding boobs and get to know what your boobs look and feel like normally.

Keep your eyes peeled because these ads will be coming to a magazine, billboard and shop changing room near you! ”

Sources and More Information:

GlaxoSmithKline fined £300 Million by China in Bribery Case

GSK admits it is at fault, will not appeal, and issued a statement of apology to the people of China

gsk logo image
The Chines GSK case involved accusations of criminal bribery to persuade hospitals and doctors to administer or sell the company’s pharmaceuticals to their patients.

In July 2012, the U.S. State Department had fined GSK $3 billion for marketing drugs for unapproved uses.

September 2004, after a one-day secret trial, a Chinese court has fined the giant British pharmaceutical company GlaxoSmithKline (GSK) £297 million (3 billion RMB at a currency exchange rate of 10.0980). for bribing hospitals and doctors to use their products.

The court also sentenced GSK’s former country manager Mark Reilly as well as four additional managers to prison time of up to four years. However, the sentences were suspended, and the managers will avoid prison with good behavior–though Reilly must leave the country.

GSK admits it’s at fault, will not appeal, and issued a statement of apology.

Sources and More Information:

  • China Fines GlaxoSmithKline Nearly $500 Million in Bribery Case, NY Times, SEPT. 19, 2014.
  • GSK China Investigation Outcome, GSK press release, 19 September 2014.
  • GSK statement of apology to the people of China, GSK media/526041, 19 September 2014.

Prenatal Exposure to Phthalates may increase the Risk of Asthma among Children

Phthalates, found in food packaging and other household items, have been linked to an increased risk of asthma in children

Phthalates, found in food packaging and other household items, have been linked to an increased risk of asthma in children.

New York City children exposed in the womb to moderate levels of two plasticizers had a 72 to 78 percent higher chance of developing asthma, according to a new study published in Environ Health Perspectives.

The study is the first to link childhood asthma, which has been increasing in recent decades, to prenatal exposure to phthalates.

These results suggest that phthalates may be one of the factors associated with that increase,” said Robin Whyatt, a Columbia University environmental health scientist who led the study. She added, however, that more studies are needed to understand how important a risk factor these chemicals may be.

Phthalates, used in the manufacture of vinyl and some cosmetics, have been connected to a number of health effects in lab animal and human studies, including airway inflammation, altered male genitalia, attention and learning problems and premature births.

2014 Study Abstract

Background
Studies suggest that phthalate exposures may adversely affect child respiratory health.

Objectives
We evaluated associations between asthma diagnosed in children between 5 and 11 years of age and prenatal exposures to butylbenzyl phthalate (BBzP), di-n-butyl phthalate (DnBP), di(2-ethylhexyl) phthalate (DEHP), and diethyl phthalate (DEP).

Methods
Phthalate metabolites were measured in spot urine collected from 300 pregnant inner-city women. Children were examined by an allergist or pulmonologist based on the first parental report of wheeze, other respiratory symptoms, and/or use of asthma rescue/controller medication in the preceding 12 months on repeat follow-up questionnaires. Standardized diagnostic criteria were used to classify these children as either having or not having current asthma at the time of the physician examination. Children without any report of wheeze or the other asthma-like symptoms were classified as nonasthmatics at the time of the last negative questionnaire. Modified Poisson regression analyses were used to estimate relative risks (RR) controlling for specific gravity and potential confounders.

Results
Of 300 children, 154 (51%) were examined by a physician because of reports of wheeze, other asthma-like symptoms, and/or medication use; 94 were diagnosed with current asthma and 60 without current asthma. The remaining 146 children were classified as nonasthmatic. Compared with levels in nonasthmatics, prenatal metabolites of BBzP and DnBP were associated with a history of asthma-like symptoms (p < 0.05) and with the diagnosis of current asthma: RR = 1.17 (95% CI: 1.01, 1.35) and RR = 1.25 (95% CI: 1.04, 1.51) per natural log-unit increase, respectively. Risk of current asthma was > 70% higher among children with maternal prenatal BBzP and DnBP metabolite concentrations in the third versus the first tertile.

Conclusion
Prenatal exposure to BBzP and DnBP may increase the risk of asthma among inner-city children. However, because this is the first such finding, results require replication.

Sources and More Information:

  • Asthma in Inner-City Children at 5-11 Years of Age and Prenatal Exposure to Phthalates: The Columbia Center for Children’s Environmental Health Cohort, Environ Health Perspect; DOI:10.1289/ehp.1307670, 17 September 2014. PDF and Supplemental Material.
  • Kids exposed in the womb to plasticizers more likely to have asthma, Environmental Health News, Sept. 17, 2014.
  • Some household plastics could increase risk of childhood asthma, study finds, The Guradian sustainable-business, 17 September 2014.

Cervical Cancer Screening: could a simple Urine Test replace invasive Smear Tests?

Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systematic review and meta-analysis

A simple urine test which can detect the human papilloma virus (HPV) could offer women a much less invasive alternative to the cervical cancer screening or ‘smear’ test, experts have said.

New research published in The BMJ has revealed that the tests are accurate and efficient, and the doctors behind the study said that offering the test could help reverse a fall in the number of young women being screened for possible cancer.

Abstract

Image of the The BMJ logo
Testing urine for HPV seems to have good accuracy for the detection of cervical HPV.

Objective
To determine the accuracy of testing for human papillomavirus (HPV) DNA in urine in detecting cervical HPV in sexually active women.

Design
Systematic review and meta-analysis.

Data sources
Searches of electronic databases from inception until December 2013, checks of reference lists, manual searches of recent issues of relevant journals, and contact with experts.

Eligibility criteria
Test accuracy studies in sexually active women that compared detection of urine HPV DNA with detection of cervical HPV DNA.

Data extraction and synthesis
Data relating to patient characteristics, study context, risk of bias, and test accuracy. 2×2 tables were constructed and synthesised by bivariate mixed effects meta-analysis.

Results
16 articles reporting on 14 studies (1443 women) were eligible for meta-analysis. Most used commercial polymerase chain reaction methods on first void urine samples. Urine detection of any HPV had a pooled sensitivity of 87% (95% confidence interval 78% to 92%) and specificity of 94% (95% confidence interval 82% to 98%). Urine detection of high risk HPV had a pooled sensitivity of 77% (68% to 84%) and specificity of 88% (58% to 97%). Urine detection of HPV 16 and 18 had a pooled sensitivity of 73% (56% to 86%) and specificity of 98% (91% to 100%). Metaregression revealed an increase in sensitivity when urine samples were collected as first void compared with random or midstream (P=0.004).

Limitations
The major limitations of this review are the lack of a strictly uniform method for the detection of HPV in urine and the variation in accuracy between individual studies.

Conclusions
Testing urine for HPV seems to have good accuracy for the detection of cervical HPV, and testing first void urine samples is more accurate than random or midstream sampling. When cervical HPV detection is considered difficult in particular subgroups, urine testing should be regarded as an acceptable alternative.

Sources and More Information:
  • Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systematic review and meta-analysis, BMJ 2014;349:g5264, 16 September 2014.
  • New urine test could replace invasive smear tests, TheIndependent Health News 9736609, 17 September 2014.
  • HPV urine test could screen for cervical cancer, NHS Choices, cancer, 17 September 2014.

Benefits and Dangers of Supplements

Pregnant women should stay away from all supplements with the exception of a prenatal vitamin

There are not as many regulations or as much research done on supplements as there is for medications, so the most important thing is to make sure you talk to your doctor.

From multivitamins to supplements that pledge to help with everything from depression to treating athlete’s foot, whole stores are filled with these alternative medications. With so many options out there it can be difficult for patients to know what is beneficial or even where to start.

Because there is little research on the effects of supplements on a fetus Michelfelder suggests pregnant women stay away from all supplements with the exception of a prenatal vitamin.

Read What you should know about the benefits, dangers of supplements, LoyolaMedicine, Newswire.

Will we see Children Brain Scans for ADHD early Diagnosis in the Future?

Brain scans offer clues into ADHD

The findings could help understand other disorders that are caused in differences in the connections in the brain, including autism and schizophrenia.

U.S. researchers analysed brain scans of 323 children with and without ADHD and found that key connections in the brains of those with the disorder developed more slowly than those without it. In the future, brain scan could help diagnose the condition, they said.

Sources and More Information:

  • Doctors could soon diagnose ADHD in children with a brain scan, MailOnline Health article-2756747, 15 September 2014.
  • Brain scans offer clues into ADHD,
    NHS Choices Neurology, 16 September 2014.
  • Lag in maturation of the brain’s intrinsic functional architecture in attention-deficit/hyperactivity disorder, PNAS doi: 10.1073/pnas.1407787111, September 15, 2014
  • Study Supporting Information, PNAS Sripada et al. 10.1073/pnas.1407787111