Hormones in Dairy, Meat You eat…

What’s in your meat? Drugs, cleaning chemicals, hormones, antibiotics, heavy metals, toxins and bacteria!

a comics via @OrganicLiveFood

” The cows in many US farms are routinely injected with synthetic hormones such as Bovine growth hormones, zeranol, trenbolone acetate and melengestrol acetate that are linked to early puberty as well as breast cancer.

Most cows are also fed with Monsanto’s GMO corn and receive growth hormones (to increase the profit by growing animals faster and squeezing them into small spaces).

There are also up to 20 different hormones (both natural oestrogen and 7-beta-estradiol), antibiotics, anti-fungal drugs, steroids and Anti-malaria drugs (pyrimethamine) in milk and dairy products. ”

Sources and More Information by @OrganicLiveFood:
On Flickr®

Watch the Diaporama, and the health comics album on  DES Diethylstilbestrol's photostream on Flickr

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Email your photos to des.daughter@gmail.com with a short description and title :-)

2nd Preventing Overdiagnosis Conference – Oxford

#PODC2014 Sept. 15-17 2014, Oxford UK

PODC2018 Copenhagen

  • August 20th – 22nd, 2018.
  • More information here and here. Visit Preventing Overdiagnosis website.
  • A clear insight about over diagnosis in less than 3 mns : The Concern about Overdiagnosis.
  • Read Preventing overdiagnosis: the myth, the music, and the medical meeting, BMJ 350:h1370, 18 March 2015.

PODC2017 Quebec

PODC2016 Barcelona

  • More information here.

PODC2015 Washington

  • More information here.

PODC2014 Oxford

  • More information here.
2014 Preventing Overdiagnosis Conference Flier
Follow the conference on Twitter at #PODC2014.

Following the BMJ Campaign “Too Much Medicine” and the success of the 2013 conference, the second preventing overdiagnosis conference will be hosted by the Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford UK.

Advanced Breast Cancer Treatment : 2014 Breast Cancer Symposium Guidelines

Key Research from the 2014 Breast Cancer Symposium,
Advances in Breast Cancer Prevention, Screening, and Therapy

During the 2014 Brest Cancer symposium, the American Society of Clinical Oncology – ASCO – has released updated guidelines for the treatment of the major form of advanced breast cancer.

HER2-negative breast tumors include cancers that don’t respond to drugs that target the HER2 protein, Almost 80 percent of women with advanced breast cancer have HER2-negative tumors, the group noted.

Abstract

asco logo image
ASCO is the American Society of Clinical Oncology. Making a world of difference in cancer care.

Purpose
To identify optimal chemo- and targeted therapy for women with human epidermal growth factor 2 (HER2)– negative (or unknown) advanced breast cancer.

Methods
A systematic review of randomized evidence (including systematic reviews and meta-analyses) from 1993 through to current was completed. Outcomes of interest included survival, progression-free survival, response, quality of life, and adverse effects. Guideline recommendations were evidence based and were agreed on by the Expert Panel via consensus.

Results
Seventy-nine studies met the inclusion criteria, comprising 20 systematic reviews and/or meta-analyses, 30 trials on first-line treatment, and 29 trials on second-line and subsequent treatment. These trials form the evidence base for the guideline recommendations.

Recommendations
Endocrine therapy is preferable to chemotherapy as first-line treatment for patients with estrogen receptor–positive metastatic breast cancer unless improvement is medically necessary (eg, immediately life-threatening disease). Single agent is preferable to combination chemotherapy, and longer planned duration improves outcome but must be balanced against toxicity. There is no single optimal first-line or subsequent line chemotherapy, and choice of treatment will be determined by multiple factors including prior therapy, toxicity, performance status, comorbid conditions, and patient preference. The role of bevacizumab remains controversial. Other targeted therapies have not so far been shown to enhance chemotherapy outcome in HER2-negative breast cancer.

Sources and More Information:
  • Chemotherapy and Targeted Therapy for Women With Human Epidermal Growth Factor Receptor 2–Negative (or unknown) Advanced Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline, American Society of Clinical Oncology, 10.1200/JCO.2014.56.7479, September 2, 2014.
  • New Guidelines for Treating Form of Advanced Breast Cancer, MedlinePlus, September 2, 2014.
  • #BCS14 meeting abstracts and daily news..

Ovarian Cancer Infographic

Often labelled a ‘silent killer’, ovarian cancer has signs you should look out for

Ovarian Cancer Infographic
Learn to identify these ovarian cancer symptoms and aim for early detection…

Ovarian Cancer Main Symptoms:

  • Persistent pelvic and/or abdominal pain
  • Increased abdominal size and/or persistent bloating
  • Needing to urinate urgently or very often
  • Difficulty eating and/or feeling full quickly
Sources and More Information:
On Flickr®

Exposure of pregnant women to parabens and triclosan may disrupt the growth of boys

Phenol perinatal exposures can affect weight at birth and during early life in experimental studies

parabens in cosmetics
Parabens are commonly used as preservatives in cosmetics and healthcare products.

Medical researchers have found that exposure to certain common phenols during pregnancy, especially parabens and triclosan, may disrupt growth of boys during fetal growth and the first years of life. Parabens are commonly used as preservatives in cosmetics and healthcare products and triclosan are an antibacterial agent and pesticide found in some toothpastes and soaps.

Background:
Phenol perinatal exposures can affect weight at birth and during early life in experimental studies. Human studies suggested associations between prenatal exposure and birth outcomes but none described effects on weight and height in childhood.

Objectives:
We studied the association of maternal pregnancy exposure to phenols with male offspring postnatal growth.

Methods:
We measured 9 phenols in spot maternal urine collected during pregnancy. We predicted individual growth trajectories and velocities using weight and height measured the first 3 years of life (at least 4 measures per child), and also assessed abdominal circumference (AC), tricipital and subscapular skinfold thicknesses at 3 years. We studied associations between growth parameters and phenol concentrations using adjusted linear regression models.

Results:
Methylparaben concentration was positively associated with weight and height predicted at 6, 18 and 30 months (p-values 0.02–0.13) and with AC at 36 months (? = 4.2 mm; 95% confidence interval (CI), 0.7; 7.8). Association patterns for the other parabens were similar but weaker. After adjustment for child height, weight at 18 and 30 months respectively increased by 112 (95% CI, 21; 203) and 128 g (95% CI, 21; 236) for each interquartile range increase in bisphenol A (BPA) concentration. BPA was also positively associated with weight growth at 6 and 12 months (p-values < 0.08); the associations were stronger after height adjustment (p-values ? 0.04).

Conclusion:
We relied on only 1 spot urine sample to assess exposure; because of the high variability in phenol urinary concentrations reported during pregnancy, using only 1 sample may result in exposure misclassification, in particular for Bisphenol-A. Nevertheless, our study lends support to a potential effect of prenatal exposure to some phenols on postnatal growth.

Sources and More Information:
  • Exposure of pregnant women to parabens and triclosan may disrupt the growth of boys, Science Daily, 140903121858, September 3, 2014.
  • Prenatal Exposure to Phenols and Growth in Boys, Epidemiology: September 2014 – Volume 25 – Issue 5 – p 625-635 doi: 10.1097/EDE.0000000000000132.

Lumpectomy plus Radiotherapy as effective as Bilateral Mastectomy

Disadvantages of a bilateral mastectomy compared to a lumpectomy include a longer recovery time and a higher risk of complications.

breast cancer surgery image
Disadvantages of a bilateral mastectomy compared to a lumpectomy include a longer recovery time and a higher risk of complications.

Bilateral mastectomy does not increase breast cancer survival chances – when compared to breast-conserving surgery plus radiation, the Daily Mail, Guardian, Independent and Mirror reported yesterday.

The news is based on the results of a large US cohort study of women with early stage breast cancer in one breast.

The study found that the 10-year mortality benefit associated with double mastectomy was the same as breast-conserving surgery (also known as lumpectomy, where the cancer and a border of healthy tissue is removed) plus radiotherapy.

Unilateral mastectomy (removal of the affected breast only) was associated with higher mortality than were the other 2 surgical options, although the absolute difference was only 4%.

Sources and More Information:

  • Lumpectomy as effective as double mastectomy, NHS Choices, Cancer, September 3 2014.
  • Use of and Mortality After Bilateral Mastectomy Compared With Other Surgical Treatments for Breast Cancer in California, 1998-2011, JAMA. 1900512 2014;312(9):902-914. doi:10.1001/jama.2014.10707.

Increasing Number of Studies linking SSRIs Prenatal Exposure to multiple Side-Effects in Newborns

Up to 14 percent of pregnant women take antidepressants

well logo image
Up to 14 percent of pregnant women take antidepressants. Some experts think it’s time to reconsider widespread use of these drugs in pregnant women altogether.

Pregnant women often go to great lengths to give their babies a healthy start in life. They quit smoking, skip the chardonnay, switch to decaf, forgo aspirin. They say no to swordfish and politely decline Brie.

Yet they rarely wean themselves from popular selective serotonin reuptake inhibitor antidepressants like Prozac, Celexa and Zoloft despite an increasing number of studies linking prenatal exposure to birth defects, complications after birth and even developmental delays and autism… ”

Continue reading Are Antidepressants Safe During Pregnancy?, Well.Blogs.NYtimes, by Roni Caryn Rabin, Sept 1, 2014.

UK Faculty of Pharmaceutical Medicine backs Greater Transparency in Clinical Trials

The FPM shows overwhelming support for the principles of clinical trial transparency

Faculty Pharm Medicine logo image
Faculty of Pharmaceutical Medicine shows overwhelming support for the principles of clinical trial transparency.

Members of the UK Faculty of Pharmaceutical Medicine have expressed backing for greater transparency in clinical trials in their first survey on the topic. They showed clear support for registration of all clinical trials, earlier publication of the summary results, and increased access to trial data.

  • 95% of survey respondents believe that all clinical trials should be registered
  • 89% believe that increased publication of clinical trial results (including negative results) will ultimately lead to better medicines and better healthcare for patients
  • 73% of respondents thought that clinical trials, irrespective of phase of development, should be published within 1– 2 years of completion (not linked to market authorisation or discontinuation of the project)
  • 87% believe that, overall, increased scrutiny of clinical trial data will result in a stronger science base and enhance medical research
  • Only 10% believe that increased publication and dissemination of clinical trial results will harm the commercial environment in which companies operate
  • 69% supported the requirement for retrospective release of clinical trials data , with the most commonly agreed time frame being data from ~5 years ago

Sources and More Information:

  • Clinical trials transparency and access to data,
    Faculty of Pharmaceutical Medicine, update, 28.8.14.
  • Faculty of Pharmaceutical Medicine survey of members on transparency in clinical trials, FPM, Analysis Report, 28.8.14.
  • Survey of pharmaceutical physicians shows overwhelming support for the principles of clinical trial transparency, FPM press release.
  • Faculty of Pharmaceutical Medicine backs greater transparency in clinical trials, BMJ, 349/bmj.g5381, 01 September 2014.

Cancer rates are rising ; what to avoid and what to eat

Habits that cause cancer,
what can we do to avoid cancer?

What common patterns are we encountering for the cancer rates to be rising so precipitously throughout North America?

Cancer rates are rising to a point where 44% of men and 39% of women will be diagnosed with the disease…

Read Daily Habits That Cause Cancer, TheEpochTimes, August 29, 2014.

Includes:

  • Habits that cause cancer
  • What can we do to avoid cancer?
    • What to eat
    • What to avoid
    • What to limit

Alana, the Girl with Three Biological Parents

Prof Lisa Jardine, the chair of the Human Fertilisation and Embryology Authority, says public opinion on 3-person IVF needs to be gauged

Prof Lisa Jardine, the chair of the Human Fertilisation and Embryology Authority, says public opinion on 3-person IVF needs to be gauged

Alana Saarinen loves playing golf and the piano, listening to music and hanging out with friends. In those respects, she’s like many teenagers around the world…

Except she’s not, because every cell in Alana’s body isn’t like mine and yours – Alana is one of a few people in the world who have DNA from three people… ”

Continue reading The girl with three biological parents, by Charlotte Pritchard on BBC News Magazine, 1 September 2014.