- Image source: THE CORRUPT WATCHDOG.
- Watch The FDA and the Drug Companies are in Bed Together, a Video Interview with @RonPaulcom.
FDA corruption and Big Pharma, by Matt Carmody
Roche: lower the cost of your breast cancer drug so public health services can afford it!
Text by Margaret Connolly
” Thirteen years ago, a five-year old boy told me all he wanted for Christmas was, “Just one thing, Auntie Margaret: Five minutes with my mummy.”
It broke my heart – his wonderful mummy, Helen Mulhearn, had suffered an awful death 16 months before due to late-diagnosed breast cancer. At that time there were not many drugs that could have helped her. Then four and a half years ago, I was found to have breast cancer too. I was lucky – I was diagnosed early, and with standard breast cancer suitable for a drug that cost just pennies, thank God.
A new drug developed by Roche, one of the biggest pharmaceutical gains in the world, could help these young women with advanced breast cancer — but Roche has priced the drug at £90,000, out of reach of both England and Scotland’s public health services. When asked why this drug was so expensive, Jennifer Cozzone — the head of pricing at Roche — actually said it reflects the “value” to the patient, effectively shutting out low-income patients!
Sign our Care2 petition today, and call on Roche to reduce the price of KADCYLA to a level that all public health services can cover! This drug should be available as a matter of course! ”
We need safe and appropriate medicine use between consumers and healthcare providers
DiEthylStilbestrol transgenerational effects on the genital tract
Potential trans-generational influence of diethylstilbestrol (DES) exposure emerged with reports of effects in grandchildren of DES-treated pregnant women and of reproductive tract tumors in offspring of mice exposed in utero to DES. Accordingly, we examined the trans-generational influence of DES on development of external genitalia (ExG) and compared effects of in utero DES exposure in CD-1 and C57BL/6 mice injected with oil or DES every other day from gestational days 12 to 18.Mice were examined at birth, and on 5–120 days postnatal to evaluate ExG malformations.
Of 23 adult (>60 days) prenatally DES-exposed males, features indicative of urethral meatal hypospadias ranged from 18% to 100% in prenatally DES-exposed CD-1 males and 31% to 100% in prenatally DES-exposed C57BL/6 males. Thus, the strains differed only slightly in the incidence of male urethral hypospadias. Ninety-one percent of DES-exposed CD-1 females and 100% of DES-exposed C57BL/6 females had urethral–vaginal fistula. All DES-exposed CD-1 and C57BL/6 females lacked an os clitoris. None of the prenatally oil-treated CD-1 and C57BL/6 male and female mice had ExG malformations.
For the second-generation study, 10 adult CD-1 males and females, from oil- and DES-exposed groups, respectively, were paired with untreated CD-1 mice for 30 days, and their offspring evaluated for ExG malformations. None of the F1 DES-treated females were fertile. Nine of 10 prenatally DES-exposed CD-1 males sired offspring with untreated females, producing 55 male and 42 female pups. Of the F2 DES-lineage adult males, 20% had exposed urethral flaps, a criterion of urethral meatal hypospadias. Five of 42 (11.9%) F2 DES lineage females had urethral–vaginal fistula. In contrast, all F2 oil-lineage males and all oil-lineage females were normal.
Thus, prenatal DES exposure induces malformations of ExG in both sexes and strains of mice, and certain malformations are transmitted to the second-generation.
Become an Antibiotic Guardian
Breast cancer in female survivors of Wilms tumor:
a report from the National Wilms Tumor late effects study
A new study has found that patients who received chest radiation for Wilms tumor, a rare childhood cancer, face an increased risk of developing breast cancer later in life due to their radiation exposure. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that cancer screening guidelines might be re-evaluated to facilitate the early diagnosis and prompt treatment of breast cancer among Wilms tumor survivors.
Wilms tumor is a rare childhood kidney cancer that can spread to the lungs. When this spread occurs, patients receive a relatively low dose of 12-14 Gray of radiation therapy to the entire chest. To see if such exposure to radiation affects patients’ risk of developing breast cancer, Norman Breslow, PhD, of the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, led a team that studied nearly 2500 young women who had been treated for Wilms tumor during childhood and who had survived until at least 15 years of age.
Of female Wilms tumor survivors who received radiation to the chest, over 20% developed breast cancer by age 40 years (3/4 invasive, 1/4 non-invasive), in contrast to only 0.3% in female Wilms tumor survivors who did not receive radiation. The researchers also found an intermediate risk (4%) of breast cancer among female Wilms tumor patients who had received abdominal but no chest radiation as part of their treatment for Wilms tumor. The rates for females receiving chest irradiation, abdominal radiation and no radiation are nearly 30, 6, and 2 times those expected among women of comparable age in the general population. This high incidence of breast cancer, including invasive cancer, was an unexpected finding.
“Current guidelines call for early screening for breast cancer among survivors of childhood cancer if they have received 20 or more Gray of radiation therapy to breast tissue. This would exclude a large majority of patients who had received whole chest radiation for Wilms tumor,” said Dr. Breslow. “Our results suggest that the risk of early breast cancer among Wilms tumor survivors is sufficiently high that early screening might be considered an option for them also.”
In an accompanying editorial, Jennifer Dean, MD and Jeffrey Dome, MD, PhD of Children’s National Health System in Washington, DC, noted that Wilms tumor survivors at high risk should undergo breast cancer surveillance with mammogram, breast MRI, or both starting at age 25 years. However, they pointed to research indicating that less than half of childhood cancer survivors considered to have a high risk for breast cancer follow through with surveillance guidelines. “Because compliance with breast cancer surveillance is low in adult survivors of childhood cancer, barriers such as education of both survivors and providers should be addressed and mitigated,” they wrote.
Pink Washing: a Cartoon by Dave Granlund
We need safe and appropriate medicine use between consumers and healthcare providers
” you still need to be cautious when it comes to any drug…”
Toujours se rapporter aux valeurs absolues pour évaluer l’efficacité d’un traitement ou d’un dépistage!
” Les promoteurs du dépistage affichent souvent un flamboyant chiffre de -30% de décès grâce au dépistage. Cela semble diablement efficace. Alors? Oui, mais ce qu’on oublie souvent de préciser, c’est que ce chiffre correspond à une diminution RELATIVE du taux de décès.
Ce stratagème est très souvent employé par les laboratoires pharmaceutiques lorsqu’ils veulent convaincre les médecins peu regardant que leur nouveau médicament est super efficace…
Toujours se rapporter aux valeurs absolues pour évaluer l’efficacité d’un traitement ou d’un dépistage! ”
Drkalee et DrParagliding abordent les grandes lignes d’un problème extrêmement débattu ; le dépistage systématique (ou “aveugle”) de toute femme présumée sans risque connu de cancer du sein:
Association of National Air Toxics Assessment Exposures and the Risk of Childhood Autism Spectrum Disorder
Children with autism spectrum disorder (ASD) were more likely to have been exposed to higher levels of certain air toxics during their mothers’ pregnancies and the first two years of life compared to children without the condition, according to the preliminary findings of a University of Pittsburgh Graduate School of Public Health investigation of children in southwestern Pennsylvania.
Autism spectrum disorders (ASD) constitute a major public health problem, affecting one in every 68 children. There is little understanding of the cause of ASD despite its serious social impact. Air pollution contains many toxicants known to have adverse effects on the developing fetus.
We conducted a population-based case control study in six southwestern PA counties estimating the association between ASD and USEPA census tract modeled NATA levels for 30 neurotoxicants. Cases were recruited from local ASD treatment centers. There were two different control groups:
Logistic regression analysis was conducted using quartiles of exposure, adjusting for age of mother, smoking, race, and education.
There were a total of 217 cases.
Chromium, cyanide and styrene exhibited elevated odds ratios using two different control groups. These findings need to be verified with exposure assessment at the individual level.