Endocrine Disruptors Effects on Male and Female Reproductive Systems

This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population

Effects on Male and Female Reproductive Systems, Second Edition
by Rajesh K. Naz, 2004 CRC Press

Endocrine-Disruptors book cover image
This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population.

There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of these endocrine disruptors, it is imperative to update our knowledge of these controversial chemicals.

Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition examines the reproductive and health hazards of endocrine-disrupting environmental chemicals from epidemiology to etiology, concluding with future directions. Divided into two sections, the first part of the book describes the effects of environmental toxicants on the female reproductive system, with an emphasis on the effects and mechanisms of their action on sex differentiation during development, fertility, and breast cancer. The second part addresses the effects of endocrine disruption on the male reproductive system, focusing on male fertility and the development of benign prostate hyperplasia (BPH) and prostate cancer.

Leading authorities contribute expert analyses and up-to-date information on a topic that has become a major concern among the scientific community and the general public. This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population.

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Three-Person IVF : could the UK be on the brink of a “historical mistake” ask scientists?

Go ahead and give your opinion!

UK parliament- image
#ThreePersonIVF babies could be at greater risk of cancer and premature ageing, and would need to be monitored all their lives, experts have said as they warn the UK it could be on the brink of a “historical mistake”!

The United Kingdom is on course to become the first country to allow in vitro fertilisation (IVF) to create babies using biological material from three people to prevent serious inherited disease, after MPs voted overwhelmingly in favour of the procedure, reports the BMJ.

The UK House of Commons voted by 382 to 128 to approve regulations allowing mitochondrial donation, after MPs were given a free vote of conscience on the issue.

The Telegraph is asking your opinion:




and interestingly,  the general public results look quite different from the MP’s vote…





Go ahead and give your opinion!

Sources and more information

Smear Test Invitation Overdue?

a @JoTrust Poster – #CervicalCancer #PAPsmear

Smear Test Invitation Overdue? Image via @JoTrust.
Watch @DES_Journal diaporama and health posters album on Flickr.

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The association of EDC exposure with earlier age of menopause

High levels of chemicals found in plastics, personal-care products, common household items and the environment have been linked to an early decline in ovarian function

Earlier menopause linked to everyday chemical exposures image
High levels of chemicals found in plastics, personal-care products, common household items and the environment have been linked to an early decline in ovarian function.


Endocrine-disrupting chemicals (EDCs) adversely affect human health. Our objective was to determine the association of EDC exposure with earlier age of menopause.

Cross-sectional survey using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2008 (n = 31,575 females). Eligible participants included: menopausal women >30 years of age; not currently pregnant, breastfeeding, using hormonal contraception; no history of bilateral oophorectomy or hysterectomy. Exposures, defined by serum lipid and urine creatinine-adjusted measures of EDCs, data were analyzed: > 90th percentile of the EDC distribution among all women, log-transformed EDC level, and decile of EDC level. Multi linear regression models considered complex survey design characteristics and adjusted for age, race/ethnicity, smoking, body mass index. EDCs were stratified into long (>1 year), short, and unknown half-lives; principle analyses were performed on those with long half-lives as well as phthalates, known reproductive toxicants. Secondary analysis determined whether the odds of being menopausal increased with EDC exposure among women aged 45–55 years.

This analysis examined 111 EDCs and focused on known reproductive toxicants or chemicals with half-lives >1 year. Women with high levels of β-hexachlorocyclohexane, mirex, p,p’-DDE, 1,2,3,4,6,7,8-heptachlorodibenzofuran, mono-(2-ethyl-5-hydroxyhexyl) and mono-(2-ethyl-5-oxohexyl) phthalate, polychlorinated biphenyl congeners −70, −99, −105, −118, −138, −153, −156, −170, and −183 had mean ages of menopause 1.9 to 3.8 years earlier than women with lower levels of these chemicals. EDC-exposed women were up to 6 times more likely to be menopausal than non-exposed women.

This study of a representative sample of US women documents an association between EDCs and earlier age at menopause. We identified 15 EDCs that warrant closer evaluation because of their persistence and potential detrimental effects on ovarian function. Earlier menopause can alter the quantity and quality of a woman’s life and has profound implications for fertility, human reproduction, and our global society.

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UICC CEO Message on World Cancer Day 2015

For World Cancer Day 2015, the year theme is #NotBeyondUs

Cary Adams, CEO of UICC explains why World Cancer Day is important and encourages people around the world to mark World Cancer Day 2015.

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  • Union for International Cancer Control (UICC) is a membership organisation that exists to help the global health community accelerate the fight against cancer.Founded in 1933 and based in Geneva, UICC’s growing membership of over 760 organisations across 155 countries, features the world’s major cancer societies, ministries of health, research institutes and patient groups.Together with its members, key partners, the World Health Organization, World Economic Forum and others, UICC is tackling the growing cancer crisis on a global scale.
  • Video published on 27 Jan 2015 by UICC channel.
  • Watch more media videos on @DES_Journal YouTube channel.

Preventing Cervical Cancer Infographic

Prevent Cervical Cancer with the Right Test at the Right Time

prevent-cervical-cancer infographic
Prevent Cervical Cancer with the Right Test at the Right Time.
Watch @DES_Journal diaporama and infographics album on Flickr. Image via @CDC_Cancer.

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Vitamin drinks: little evidence that consumers benefit from the micronutrients found in those products

Some nutrition scientists are concerned that with the profusion of fortified foods, beverages and supplements, many people may be ingesting levels of vitamins and other nutrients that are not only unnecessary, but potentially harmful…

vitamin-drinks image
Some nutrition scientists are concerned that with the profusion of fortified foods, beverages and supplements, many people may be ingesting levels of vitamins and other nutrients that are not only unnecessary, but potentially harmful… Image via Julien GONG Min.

2014 Study Abstract

Changing regulatory approaches to fortification in Canada have enabled the expansion of the novel beverage market, but the nutritional implications of these new products are poorly understood. This study assessed the micronutrient composition of energy drinks, vitamin waters, and novel juices sold in Canadian supermarkets, and critically examined their on-package marketing at 2 time points: 2010-2011, when they were regulated as Natural Health Products, and 2014, when they fell under food regulations. We examined changes in micronutrient composition and on-package marketing among a sample of novel beverages (n = 46) over time, compared micronutrient content with Dietary Reference Intakes and the results of the 2004 Canadian Community Health Survey to assess potential benefits, and conducted a content analysis of product labels. The median number of nutrients per product was 4.5, with vitamins B6, B12, C, and niacin most commonly added. Almost every beverage provided at least 1 nutrient in excess of requirements, and most contained 3 or more nutrients at such levels. With the exception of vitamin C, there was no discernible prevalence of inadequacy among young Canadian adults for the nutrients. Product labels promoted performance and emotional benefits related to nutrient formulations that go beyond conventional nutritional science. Label graphics continued to communicate these attributes even after reformatting to comply with food regulations. In contrast with the on-package marketing of novel beverages, there is little evidence that consumers stand to benefit from the micronutrients most commonly found in these products..

Sources and more information
  • NCBI PubMed PMID: 25577949, Appl Physiol Nutr Metab. 2015 Feb;40(2):191-8. doi: 10.1139/apnm-2014-0252. Epub 2015 Jan 12.
  • Are Vitamin Drinks a Bad Idea? well.blogs.nytimes, JANUARY 30, 2015.

Action for Breast Cancer Foundation in Malta

For World Cancer Day 2015, the year theme is #NotBeyondUs

WCD15 poster
HEAL is participating in World Cancer Day 2015 in Malta, backing action on environmental pollutants to close gap in cancer prevention.

Action for Breast Cancer Foundation in Malta is organising a both a morning and evening event for the World Cancer Day on February 4th at the Verdala Palace under the Distinguished Patronage of Her Excellency Marie Louise Coleiro Preca, President of Malta.

The Conference will focus on Environmental Policy as a lever for cancer prevention and it is aimed for Health and Environmental NGO’s, Health Care Professionals, Medical doctors, Medical and Health Science Students etc.

Génon K Jensen, Executive Director of Health and Environment Alliance (HEAL), is a keynote speaker and will welcome Malta’s initiative to emphasise the often forgotten aspect of the fight against cancer.

HEAL welcomes Malta’s initiative on World Cancer Day to highlight a missing link in cancer prevention by focussing on the role of environmental policy. We hope the experience can inspire other European countries to take up the issue during European Week against Cancer in May.

Within the past 18 months, the World Health Organization’s cancer agency (IARC) has officially recognised air pollution as a contributor to lung cancer. The experts also noted a positive association between higher levels of air pollution and an increased risk of bladder cancer.

Some chemicals in the work and home environment are known to be carcinogenic; others disrupt the human hormone system and are associated with hormonal cancers, such as breast cancer and prostate cancer. The incidence of both these cancers is high having increased rapidly in recent decades in Europe. Experts are in agreement that these upward trends cannot derive from genetics, or an aging population nor on better screening alone; environmental factors, especially exposure to certain hazardous chemicals, is one of the likely causes.

National cancer plans often address environmental factors – but much more needs to be done if the opportunities for primary prevention of cancer are to be fully optimised. “

HEAL’s work on Cancer & Environment

HEAL has been working since its inception in 2003 to bring attention to opportunities for preventing chronic conditions, including cancer, through the promotion of a less toxic environment.

More information
  • Further expected guests and speakers are amongst others EU Commissioner Karmenu Vella , Prof. Christian Scerri from the University of Malta, Esther Sant from Action for Breast Cancer Foundation, Europa Donna Malta and many more.
  • World Cancer Day is a global event taking place every year on February 4th with the aim to unite all for the fight against cancer and raising awareness about cancer and prevention.
  • Please find here the full programme of the event for the morning event and evening event.
  • Please find here the registrations links for either the morning session or evening session.
  • Environmental protection of personal importance to 99% of Maltese, timesofmalta, February 4, 2015.
Original post
  • HEAL participating in World Cancer Day 2015 in Malta,
    chemicalshealthmonitor.org blog latest news, FEBRUARY 2, 2015.

Coming to Term

Uncovering the Truth about Miscarriage

Coming-to-term book cover image
Watch @DES_Journal diaporama and health books album on Flickr. Coming to Term, Uncovering the Truth about Miscarriage.

After his wife lost four pregnancies, Jon Cohen set out to gather the most comprehensive and accurate information on miscarriage – a topic shrouded in myth, hype, and uncertainty. The result of his mission is a uniquely revealing and inspirational book for every woman who has lost at least one pregnancy – and for her partner, family, and close friends.

Approaching the topic from a reporter’s perspective, Cohen takes us on an intriguing journey into the laboratories and clinics of researchers at the front, weaving together their cutting-edge findings with intimate portraits of a dozen families who have had difficulty bringing a baby to term. Couples who seek medical help for miscarriage often encounter conflicting information about the causes of pregnancy loss and ways to prevent it. Cohen’s investigation synthesizes the latest scientific findings and unearths some surprising facts. We learn, for example, that nearly seven out of ten women who have had three or more miscarriages can still carry a child to term without medical intervention. Cohen also scrutinizes the full array of treatments, showing readers how to distinguish promising new options from the useless or even dangerous ones.

Coming to Term” is the first book to turn a journalistic spotlight on a subject that has remained largely in the shadows. With an unrelenting eye and the compassion that comes from personal experience, Jon Cohen offers a message that is both enlightening and unexpectedly hopeful.

More information

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Woman who was genetically a man and born with no womb gives birth to miracle twin girls

Hayley Haynes, 28, had miracle babies Avery and Darcey after undergoing IVF treatment using an egg donor

Hayley Haynes has a unique condition called Androgen Insensitivity Syndrome, which means she appears female but was born with X & Y chromosomes…which technically makes her male. She was born without fallopian tubes, ovaries and womb, which made having a child impossible…or was it? Maybe not, thanks to modern medicine and science. It’s a story with a happy ending, yes?.

More information
  • Video published on 31 Jan 2015 by LordSpoda channel.
  • Woman born with no womb gives birth to miracle twins, telegraph, 31 Jan 2015.
  • Woman who was genetically a man gives birth to TWINS after doctors GREW her a womb, mirror, 30 January 2015.
  • Watch more research videos on @DES_Journal YT channel.