Diethylstilbestrol injection for livestock

How did You get your dose of DES?

diethylstilbestrol_veterinary
Watch @DES_Journal diaporama and DES drugs album on Flickr.

Stilbosol patenting turned the cattle feed industry upside down in the mid fifties with its phenomenal use by the farmers.

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Hormone Disruptors Linked To Genital Changes and Sexual Preference

Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses

Tyrone Hayes’ at work in his lab in Berkeley

Scientists are continuing to sound the alarm about some common chemicals, including the herbicide atrazine, and link them to changes in reproductive health and development. Endocrine disrupting toxic chemicals have been found to feminize male frogs and cause homosexual behavior. Ashley Ahearn reports on how these substances may be affecting human development and behavior.

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État de Santé : Perturbateurs endocriniens : soyons vigilants!

Les perturbateurs endocriniens, en savoir plus

Depuis le 2 avril 2014, Ségolène Royal est ministre de l’Écologie, du Développement durable et de l’Énergie du gouvernement Valls. La Ministre a remis au Parlement en juin 2014 un rapport relatif aux perturbateurs endocriniens et a engagé le gouvernement dans une stratégie nationale qui vise notamment à réduire l’exposition de la population aux perturbateurs endocriniens et en faire un axe essentiel de la recherche en santé environnementale.

  1. Les perturbateurs endocriniens, qu’est-ce que c’est?
  2. Les effets des perturbateurs endocriniens sur la santé : l’exemple des pesticides en Gironde.
En savoir plus

Endocrine-Disrupting Chemicals: The Endocrine Society 2009 Scientific Statement

EDCs side effects reviewed by The Endocrine Society

chemicals image
In 2009, The Endocrine Society made a number of recommendations to increase understanding of effects of EDCs, including enhancing increased basic and clinical research, invoking the precautionary principle, and advocating involvement of individual and scientific society stakeholders in communicating and implementing changes in public policy and awareness. Image by jill570641.

2009 Study Abstract

There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction.

In this first Scientific Statement of The Endocrine Society, we present the evidence that endocrine disruptors have effects on male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology.

Results from animal models, human clinical observations, and epidemiological studies converge to implicate EDCs as a significant concern to public health. The mechanisms of EDCs involve divergent pathways including (but not limited to) estrogenic, antiandrogenic, thyroid, peroxisome proliferator-activated receptor γ, retinoid, and actions through other nuclear receptors; steroidogenic enzymes; neurotransmitter receptors and systems; and many other pathways that are highly conserved in wildlife and humans, and which can be modeled in laboratory in vitro and in vivo models. Furthermore, EDCs represent a broad class of molecules such as organochlorinated pesticides and industrial chemicals, plastics and plasticizers, fuels, and many other chemicals that are present in the environment or are in widespread use.

We make a number of recommendations to increase understanding of effects of EDCs, including enhancing increased basic and clinical research, invoking the precautionary principle, and advocating involvement of individual and scientific society stakeholders in communicating and implementing changes in public policy and awareness.

Overview
  1. General Introduction to Endocrine Disruption
    1. Important issues in endocrine disruption
    2. The role of endocrinologists in discerning effects of EDCs
  2. Overview of Endocrine Disruption and Reproductive Health from a Clinical Perspective
    1. Clinical aspects of endocrine disruption in humans
    2. Clinical dimorphism of EDCs on male and female reproduction
    3. Experimental and clinical evidence of EDCs and potential mechanisms
  3. Clinical and Translational Impacts of EDCs on Female Reproduction
    1. Introduction to female reproductive development and function
    2. Polycystic ovarian syndrome (PCOS)
    3. Premature ovarian failure, decreased ovarian reserve, aneuploidy, and granulosa steroidogenesis
    4. Reproductive tract anomalies
    5. Uterine leiomyomas
    6. Endometriosis
  4. Endocrine Disruptors, Mammary Gland Development, and Breast Cancer
    1. Windows of vulnerability to carcinogenic agents and “natural” risk factors
    2. Theories of carcinogenesis
    3. Susceptibility of the breast during puberty and adulthood
    4. Susceptibility of the mammary gland during the perinatal period
    5. Perinatal exposure to environmentally relevant levels of endocrine disruptors
  5. Male Reproductive and Developmental Health: The Human Evidence
    1. Introduction to male reproductive health
    2. Male reproductive function and development
    3. Semen quality: temporal trends and EDC exposure
    4. Male urogenital tract malformations
    5. Testicular germ cell cancer
    6. Conclusions
  6. Prostate Cancer
    1. Introduction to prostate cancer
    2. Evidence and mechanisms for EDC effects on the prostate
  7. Neuroendocrine Targets of EDCs
    1. Endocrine disruption of reproductive neuroendocrine systems
    2. Hypothalamic-pituitary-adrenal (HPA) effects of EDCs
    3. Thyroid, metabolism, and growth
    4. Hormonal targets of neuroendocrine disruption
  8. Thyroid Disruption
    1. Introduction to thyroid systems
    2. Environmental chemicals impacting thyroid function
    3. Environmental chemicals impacting thyroid hormone transport, metabolism, and clearance
    4. Environmental chemicals impacting the thyroid hormone receptor
  9. Environmental Chemicals, Obesity, and Metabolism
    1. Introduction to EDCs and the obesity epidemic
    2. Environmental estrogens and obesity
    3. Peroxisome proliferator-activated receptor (PPAR) γ and organotins
    4. Phytoestrogens
    5. Endocrine disruptors, diabetes, and glucose homeostasis
    6. Endocrine disruptors and cardiovascular systems
    7. Estrogenic EDCs and cardioprotection
    8. Advanced glycation end-products (AGEs)
    9. Conclusions
  10. Recommendations for the Future
    1. Linking basic research to clinical practice
    2. Endocrine disruption and the public
    3. Prevention and the “precautionary principle”
    4. Specific recommendations for future research

Read the full paperEndocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement, NCBI PMCID: PMC2726844, Evanthia Diamanti-Kandarakis, Jean-Pierre Bourguignon, Linda C. Giudice, Russ Hauser, Gail S. Prins, Ana M. Soto, R. Thomas Zoeller, and Andrea C. Gore, doi: 10.1210/er.2009-0002, Endocr Rev. 2009 Jun; 30(4): 293–342.

Endocrine Disruptors

Viagra for Women

2013 cartoon by Mac from The Daily Mail

viagra-for-women cartoon
Mac on… Viagra for women. Published: 27 May 2013 @MailOnline

This 2013 cartoon by Mac from The Daily Mail related to the MailOnline 2013 news that female Viagra that boosts a woman’s sex drive could be on the market within three years…

Sexual orientation after prenatal exposure to exogenous estrogen

1985 study: the DES women showed increased bisexuality and homosexuality

sexual-orientation image
In this 1985 study, the DES women showed increased bisexuality and homosexuality. Image by torbakhopper.

1985 Study Abstract

Thirty women aged 17 to 30 years with documented prenatal exposure to the nonsteroidal synthetic estrogen diethylstilbestrol (DES) were compared to thirty women of similar demographic characteristics from the same medical clinic who had a history of abnormal Pap smear findings. A subsample of the DES women were also compared to their DES-unexposed sisters. Sexual orientation in its multiple components was assessed by systematic semistructured interviews. In comparison to both control groups, the DES women showed increased bisexuality and homosexuality. However, about 75% of the DES women were exclusively or nearly exclusively heterosexual. Nonhormonal and hormonal interpretations of these findings are discussed.

Sources
  • Sexual orientation after prenatal exposure to exogenous estrogen,Ehrhardt AA, Meyer-Bahlburg HF, Rosen LR, Feldman JF, Veridiano NP, Zimmerman I, McEwen BS., Arch Sex Behav. 1985 Feb;14(1):57-77. NCBI PMID: 3977584.
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Amazon v. Google: the race to get your DNA into the cloud

Amazon is in a race against Google to store data on human DNA

Amazon.com Inc is in a race against Google Inc to store data on human DNA, seeking both bragging rights in helping scientists make new medical discoveries and market share in a business that may be worth $1 billion a year by 2018.

More info and videos
  • Read Amazon, Google race to get your DNA into the cloud, Reuters, Jun 5, 2015.
  • Video published on 5 Jun 2015 by Everything.
  • Watch more research videos on our YouTube channel.

Low birth weights associated with proximity to fracking sites

Significant association’ between low birth weights and how close pregnant women live to unconventional gas drilling

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Researchers examining the proximity of pregnant women to unconventional gas drilling sites have found that those living closest to gas wells drilled with hydraulic fracturing – fracking – may be more likely to have babies with lower birth weights than those living farther away.

2015 Study Abstract

Unconventional gas drilling (UGD) has enabled extraordinarily rapid growth in the extraction of natural gas. Despite frequently expressed public concern, human health studies have not kept pace. We investigated the association of proximity to UGD in the Marcellus Shale formation and perinatal outcomes in a retrospective cohort study of 15,451 live births in Southwest Pennsylvania from 2007–2010. Mothers were categorized into exposure quartiles based on inverse distance weighted (IDW) well count; least exposed mothers (first quartile) had an IDW well count less than 0.87 wells per mile, while the most exposed (fourth quartile) had 6.00 wells or greater per mile. Multivariate linear (birth weight) or logistical (small for gestational age (SGA) and prematurity) regression analyses, accounting for differences in maternal and child risk factors, were performed. There was no significant association of proximity and density of UGD with prematurity. Comparison of the most to least exposed, however, revealed lower birth weight (3323 ± 558 vs 3344 ± 544 g) and a higher incidence of SGA (6.5 vs 4.8%, respectively; odds ratio: 1.34; 95% confidence interval: 1.10–1.63). While the clinical significance of the differences in birth weight among the exposure groups is unclear, the present findings further emphasize the need for larger studies, in regio-specific fashion, with more precise characterization of exposure over an extended period of time to evaluate the potential public health significance of UGD.

Sources and more information
  • Low birth weights associated with proximity to fracking sites, medicalnewstoday, 5 June 2015.
  • Perinatal Outcomes and Unconventional Natural Gas Operations in Southwest Pennsylvania, PLOS one, DOI: 10.1371/journal.pone.0126425, June 3, 2015.

5M cattle prove Stilbosol can slash your beef costs…

Stilbosol patenting turned the cattle feed industry upside down in the mid fifties with its phenomenal use by the farmers and feeders

stilbosol-advert-1955 image
FFA National Future Farmer, 1955, IUPUI archives.
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“Female Viagra” gets approval from FDA, with conditions

Flibanserin drug is backed by an FDA panel… theDESK video

Today on theDESK, the FDA is on the verge of approving a drug for women that acts much like Viagra, but there are serious side effects and questions about Flibanserin effectiveness.. Video published on 5 Jun 2015 by UPROXX.

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