GeneWEAVE Biosciences Inc. bought by Roche for up to $425 million

Roche acquires GeneWEAVE to strengthen offerings in microbiology diagnostics

1
Roche acquires GeneWEAVE to strengthen offerings in microbiology diagnostics.

Roche has signed a definitive agreement under which it will acquire GeneWEAVE BioSciences, Inc. Roche has been buying the company focused on innovative, clinical microbiology diagnostics solutions, for up to $425 million. With the deal, Roche has further strengthened its commitment to fight superbugs.

Sources and more information
  • Roche acquires GeneWEAVE to strengthen offerings in microbiology diagnostics, geneweave news, August 13, 2015.
  • Roche buys ‘superbug’ diagnostics firm for up to $425 million, Reuters, Aug 13, 2015.

Surdiagnostic des cancers du sein

Conférence de Bernard DUPERRAY, 2015

Spécialiste de la mammographie, le Dr Bernard Duperray apporte aux radiologues francophones un enseignement indépendant des politiques de santé à la mode. Les observations cliniques et les résultats scientifiques présentés apportent la preuve des contradictions entre la représentation classique du cancer du sein et l’histoire naturelle des maladies cancéreuses du sein, hétérogène et imprévisible.

Consultez et téléchargez ci dessous le fichier de 76 diapositives passionnantes de la conférence de Bernard DUPERRAY et vous n’aurez plus de doutes sur la réalité du surdiagnostic dans le dépistage organisé du cancer du sein.

Ce cours, qui s’adresse d’abord à des étudiants en quête d’une hyperspécialisation planifiée, est aussi accessible aux autres médecins, radiologues de centres de dépistage, gynécologues, généralistes ou pathologistes, et aux non médecins, patients ou usagers de soins.

A sa lecture, on devrait croire non pas que le dépistage organisé a une quelconque utilité sur la santé des personnes mais au contraire que tout retard de diagnostic chez une femme asymptomatique est sans conséquence sur sa mortalité.

Alors, en attendant l’octobre morose prochain de toutes les lubies de l’industrie de la peur et de la manipulation, lisez vite le cours de Bernard DUPERRAY pour prendre conscience que le surdiagnostic, produit direct et intéressé de l’activité humaine, ne pourra être neutralisé et limité qu’avec l’abandon d’un programme de dépistage aveugle et sourd aux recommandations d’épidémiologistes indépendants.

Sources:

Factory farms, antibiotics and superbugs

Lance Price at TEDxManhattan, 2014

How antibiotics are being used to compensate for the overcrowded, stressful conditions on industrial farms and how that’s creating superbugs that threaten public health.

More information
  • Lance Price is a public health researcher who works at the interface between science and policy to address the growing crisis of antibiotic resistance. In the laboratory, Dr. Price uses cutting-edge DNA sequencing to trace the origins of new antibiotic-resistant pathogens. By analyzing the genomes of bacteria found in humans, food, and livestock, Dr. Price and his colleagues have traced the origins of new superbugs to industrial livestock production. Dr. Price and his colleagues have also begun to broaden the scope of foodborne disease to include urinary tract infections caused by foodborne E. coli.In the policy arena, Dr. Price works with grassroots organizations, NGOs, and policymakers to develop science-based policies to curb antibiotic abuse in food-animal production and stem the emergence of new superbugs. Dr. Price’s work was selected by Discover Magazine as one of the top 100 science stories of 2012. His research has also been covered by top-tier media around the world, including the BBC, New York Times, Los Angeles Times, Chicago Tribune, Scientific American, Men’s Journal, and Fitness Magazine, among others.
  • Video published on 11 Mar 2014 by TEDx Talks.
  • Watch more farming, livestock videos on @DES_Journal YT channel.

What to do about all the hormonally active drugs at concentrations found in our environment?

What to do about the antidepressants, antibiotics and other drugs in our water

water-polluted
As pharmaceuticals taint rivers and lakes, scientists search for solutions.
Bubbles Bubbles but from Where? image by John Triffo.

There’s no way around it, the headlines are disturbing. And they come, not from tabloids or click-bait blogs, but from papers published in scientific journals. They describe fish and birds responding with altered behavior and reproductive systems to antidepressants, diabetes medication, and other psychoactive or hormonally active drugs at concentrations found in the environment. They report on opiods, amphetamines and other pharmaceuticals found in treated drinking water; antibiotics in groundwater capable of altering naturally occurring bacterial communities; and over-the-counter and prescription drugs found in water leaching from municipal landfills. And these are just some of many recent studies examining the countless pharmaceuticals that are now being found just about everywhere scientists have looked for them in the environment. ”

… continue reading What to do about the antidepressants, antibiotics and other drugs in our water, ensia, Elizabeth Grossman, August 11, 2015.

Squamous cell carcinoma in situ of the vagina and cervix after intrauterine DES exposure

All cases of adenosis should be followed by colposcopy

young-woman
This 1978 study recommended that all cases of adenosis be followed by colposcopy.
I think I will just image by Mary.

1978 Study Abstract

Two patients exposed in utero to maternal diethylstilbestrol DES ingestion presented with adenosis. Each developed intraepithelial neoplasia in an area of active metaplastic change.

The question is raised whether a continuum exists beginning with DES exposure and proceeding through the occurrence of adenosis and active squamous metaplasia to dysplastic alteration and finally squamous neoplasia.

Since the cytologic smear is negative in 50% of cases during the dysplastic phase, it is recommened that all cases of adenosis be followed by colposcopy.

Sources and more information
  • Squamous cell carcinoma in situ of the vagina and cervix after intrauterine DES exposure, NCBI PMID: 683639, Obstet Gynecol. 1978 Jul;52(1 Suppl):30S-33S.
More DES DiEthylStilbestrol Resources

Nos jardins et les pesticides: terreur dans le potager

Interdiction de la vente de pesticides aux particuliers en 2019, encore 4 ans de nocivité…

Terreur-dans-le-potager cartoon
Interdiction de la vente de pesticides aux particuliers en 2019, encore 4 ans de nocivité…

A noter que la loi transition énergétique pour la croissance verte adoptée le 22 juillet par l’Assemblée Nationale entrera en vigueur au 1er janvier 2019. Le futur retrait de la vente des pesticides ne concerne pas le monde agricole qui représente environ 90% des usages de pesticides…

En savoir plus

Healthy Aging for Women, an Infographic via @UF #WomensHealth

A healthy diet, exercise and regular medical checkups are the key ingredients for healthy aging for women.

healthy-aging-for-women-inf
Some of the diseases mentioned above can be blamed on a poor lifestyle.

Some baby boomers turned 60 this year…
As research has shown, a healthy diet, exercise and regular medical checkups are the key ingredients for healthy aging for women.

Sources and more information

IVF using frozen eggs associated with lower live birth rates

Outcomes of Fresh and Cryopreserved Oocyte Donation

ivf image
Compared to using fresh eggs for in vitro fertilization, use of frozen donor eggs in 2013 was associated with lower live birth rates, according to a new study in JAMA. Intothelight by Jon © all rights reserved.

Abstract

This study used data from the 2013 annual report of US in vitro fertilization center outcomes published by the Society for Assisted Reproductive Technology to compare live birth and cycle cancellation rates using either fresh or cryopreserved donor oocytes.

Use of oocytes donated for in vitro fertilization (IVF) has increased in recent years. Donated fresh oocytes traditionally have been used immediately, creating embryos for transfer into the uterus, with extra embryos being cryopreserved for later use.

In January 2013, the American Society for Reproductive Medicine declared the technique of oocyte cryopreservation (egg freezing) no longer experimental, although it called for “more widespread clinic-specific data on the safety and efficacy of oocyte cryopreservation … before universal donor oocyte banking can be recommended.” Based on data that IVF outcomes with cryopreserved and fresh donor oocytes are comparable, some IVF centers established frozen donor egg banks. However, data reflecting IVF outcomes in routine clinical practice with cryopreserved donor oocytes had not previously been published, according to background information in the article.

Sources and more information
  • Outcomes of Fresh and Cryopreserved Oocyte Donation, JAMA. 2015;314(6):623-624. doi:10.1001/jama.2015.7556, articleid=2425734, August 11, 2015.
  • In vitro fertilization using frozen eggs associated with lower live birth rates, MedicalXpress, August 11, 2015.
  • Frozen Donor Eggs May Lead to Fewer Births Than Fresh Ones, HealthDay, Aug. 11, 2015.

Confusion and Controversy: the Special Case of the Medical Innovation Bill

Bye Bye Bolitho? The Curious Case of the MIB

UK-parliament
Indeed. there seems to have been rather a lot of ‘confusion’ surrounding the #SaatchiBill campaign told me Alan Henness in our short conversation. Image credit Beat Blood Cancers.

This post content has been written by José Miola, Professor of Medical Law, University of Leicester, on Social Science Research Network – Tomorrow’s Research Today.

Abstract

The Medical Innovation Bill (MIB) was conceived and promoted by Lord Saatchi. In his view, the medical profession was failing to develop new treatments to combat illnesses such as the cancer that resulted in the death of his wife . The principal barrier he perceived to the development of new treatments was that to deviate from ‘standard treatment’ was to invite litigation, and thus doctors could not innovate because they feared being sued for it . Therefore he determined to remove the possibility of litigation in order to, hopefully, facilitate a cure for cancer. He assembled a team including a campaign manager and a parliamentary draughtsman to design and promote the Bill.

Lord Saatchi’s Bill has however caused much controversy but, despite this widespread opposition, the government has lent the Bill its support, and its passage has become a ‘PR war’.

The Bill passed the House of Lords in January 2015, but ran out of time in the House of Commons before the general election in May 2015. However, it is now back and returned to the House of Lords in June 2015. If it gets back to the House of Commons, it may well become law, given that it enjoys government support. The proposed legislation is deeply flawed though: its actual content is not as it has been presented, and its patient safety framework is both a significant downgrade on the current law and inadequate. Moreover it is internally inconsistent and cannot function, even on its own terms. For these reasons and more this paper argues that the MIB should not become law.

More Information
  • Full Paper Bye Bye Bolitho? The Curious Case of the Medical Innovation Bill, University of Leicester School of Law Research Paper No. 15-24, dx.doi.org/10.2139/ssrn.2637503 PDF, July 26, 2015.
  • Former Lord Chief Justice unable to substantiate argument for Medical Innovation Bill, solicitorsjournal, 11 December 2014.

Estrogen and Breast Cancer Risk: Factors of Exposure

Cornell University Program on Breast Cancer and Environmental Risk Factors

estrogen molecular image
Women with a high lifetime exposure to estrogen may be at higher risk for breast cancer. It is important to understand how lifestyle and environmental factors may affect the body levels of estrogen. Image Dr. P Getson.

Estrogen is a hormone that is necessary for the normal development and growth of the breasts and organs important for childbearing. It helps control a woman’s menstrual cycles and is essential for reproduction. Estrogen also helps maintain the heart and healthy bones. However, a woman’s risk for breast cancer is associated with lifetime exposure to estrogen. Understanding how estrogen works in the body, knowing about how chemicals in the environment can affect body estrogen levels, and how diet and lifestyle factors affect estrogen exposure over a lifetime, may help women make more informed decisions about their bodies and their environment.

  • What is estrogen?
  • Is estrogen exposure related to a woman’s risk for breast cancer?
  • How can lifestyle factors affect levels of estrogen in the body?
    • Diet
    • Dietary phytoestrogens
    • Body weight
    • Exercise
    • Alcohol
    • Birth control pills
    • Postmenopausal hormone treatment (hormone ‘replacement’ therapy)
  • Is there a relationship between breast cancer risk, estrogen, and environmental chemicals?
  • What are environmental estrogens?
  • Are there other chemicals that affect the levels of and types of estrogen in the body?

Read Estrogen and Breast Cancer Risk: Factors of Exposure, Cornell University Program on Breast Cancer and Environmental Risk Factors, Fact Sheet #10, March 1998, updated July 2002.