Get extra Gains when feeding Stilbosol

Stilbosol patenting turned the cattle feed industry upside down in the mid fifties with its phenomenal use by the farmers and feeders

image of a stilbosol-1957-advert
Stilbosol patenting turned the cattle feed industry upside down in the mid 50s with its phenomenal use by farmers.
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e-Santé: qu’est-ce qui a vraiment changé depuis cinq ans?

Les nouvelles informations en santé, par Dominique.Dupagne

e-santé image
Dominique Dupagne est médecin et administrateur du site médical communautaire atoute depuis 2000, sur lequel ont été postés plusieurs millions de messages. Ancien président de l’Association des médecins maîtres-toile, il a introduit en France en 2007 le concept de médecine 2.0. Image credit Studio Cigale.

Les nouvelles technologies de la communication et de l’information ont profondément transformé l’élaboration et la transmission des informations concernant la santé. Les espaces communautaires et les blogs ont modifié la hiérarchie des sources et leur usage par le public. De nouveaux acteurs, comme les “apomédiaires”, supplantent progressivement les journalistes et les experts. Cette révolution douce, qui ne fait que débuter, modifie inexorablement le paysage sanitaire et renforce la capacité du patient à accéder à des soins de qualité. “

  • Le support façonne le contenu
  • Internet et la libération de l’information médicale traditionnelle
  • La révolution 2.0
  • La nouvelle information santé ne plaît pas à tout le monde
  • “Apomédiaires” et “empowerment

Consultez Les nouvelles informations en santé, en accès libre sur Les Tribunes de la santé 4/2010 (n° 29), p. 33-39, DOI : 10.3917/seve.029.0033, par Dupagne Dominique.

Ce qui a changé, c’est la confusion entre la santé connectée (qui connecte les gens) et le fitness gadget sur smartphone.

@DDupagne 6:06 AM – 10 Aug 2016.

In-Utero DES Exposure associated with a Higher Rate of Herpes and HPV infections

Development of cervical and vaginal squamous cell neoplasia as a late consequence of in utero exposure to diethylstilbestrol

herpes-simplex-virus
In 1984, the DES-Adenosis (DESAD) Project found that DES-exposed daughters are associated with a higher rate of herpes simplex virus and human papillomavirus infections.

1988 Study Abstract

During the last 14 years, several articles have given contradictory reports on prevalence rates of squamous cell neoplasia of the cervix and vagina in diethylstilbestrol (DES)-exposed progeny.

In 1984, the DES-Adenosis (DESAD) Project found that the incidence of cervical and vaginal intraepithelial neoplasia in DES-exposed daughters was twice as high as in a comparison group of unexposed women.

This was also associated with a higher rate of herpes simplex virus and human papillomavirus infections. Possible hypotheses on the etiology of the increased incidence of squamous neoplasia are discussed.

Sources and more information
  • Development of cervical and vaginal squamous cell neoplasia as a late consequence of in utero exposure to diethylstilbestrol,
    NCBI PMID: 2829071, Obstet Gynecol Surv. 1988 Jan;43(1):15-21.
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Environmentally induced epigenetic transgenerational inheritance of disease susceptibility

Environmental epigenetics affects disease, evolution

Washington State University researchers say environmental factors are having an underappreciated effect on the course of disease and evolution by prompting genetic mutations through epigenetics, a process by which genes are turned on and off independent of an organism’s DNA sequence.

epigenetics image
Researchers exposed gestating female rats to the fungicide vinclozolin. Third generation, or great-grand offspring, had increased genetic mutations, which the researchers saw in increased DNA structure changes known as copy-number variations. Epigenetic image by Wilfredo Shimura.

2015 Study Abstract

Environmental insults, such as exposure to toxicants or nutritional abnormalities, can lead to epigenetic changes that are in turn related to increased susceptibility to disease. The focus of this review is on the transgenerational inheritance of such epigenetic abnormalities (epimutations), and how it is that these inherited epigenetic abnormalities can lead to increased disease susceptibility, even in the absence of continued environmental insult. Observations of environmental toxicant specificity and exposure-specific disease susceptibility are discussed. How epimutations are transmitted across generations and how epigenetic changes in the germline are translated into an increased disease susceptibility in the adult is reviewed with regard to disease etiology.

Sources and more information
  • Environmentally induced epigenetic transgenerational inheritance of disease susceptibility, NCBI PMCID: 24657180, PMC4148471, Transl Res. 2015 Jan;165(1):12-7. doi: 10.1016/j.trsl.2014.02.003. Epub 2014 Feb 28.
  • Study: Environmental epigenetics affects disease, evolution, Washington State University, August 3, 2015.

L’impact des pesticides sur la santé et le développement des jeunes enfants

Pesticides : “il faut abolir leur utilisation en France”

Le docteur Charles Sultan est endocrinologue et professeur au CHU de Montpellier.
Dérèglements hormonaux, obésité, asthme… il nous explique en quoi les pesticides impactent la santé et le développement des jeunes enfants.

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Higher risk of developing squamous neoplasia following prenatal Diethylstilbestrol exposure

Incidence of squamous neoplasia of the cervix and vagina in DES-exposed

High-Grade-Squamous-Intraep
In this 1978 study, it appeared that women with in utero DES exposure may be at a higher risk of developing squamous neoplasia compared with non-DES-exposed women.

1978 Study Abstract (1)

Two hundred and fifty patients were examined because of a history of in utero exposure to diethylstilbestrol (DES) or because of the presence of physical findings suggesting such exposure. One thousand biopsies were examined for the presence of neoplasia and then compared to the colposcopic findings. There were no cases of glandular or squamous cell carcinoma. Fifteen (6 per cent) of the patients had squamous cell dysplasia. The degree of dysplasia was mild in 11 and moderate in only 4 (1.6 per cent) of the women. The majority of the cases of dysplasia involved the cervix, whereas the vagina was involved in only four cases, with simultaneous cervical dysplasia in three of these. Patients with cervical mosaic and white epithelium had dysplasia on biopsy much more frequently as compared with patients with similar colposcopic appearances in the vagina. Our results suggest a low incidence of significant squamous precancerous change in the DES-exposed population and provide evidence that colposcopic data concerning dysplasia pertinent to the cervix cannot be applied without modification to the evaluation of dysplasia in vaginal adenosis.

1978 Study Abstract (2)

Among 199 women from 12 to 30 years of age who had been exposed to DES in utero, the colposcopic evaluation of the vagina and cervix was considered normal for only 13.6%. The incidence of colposcopically detected lesions was not related to the trimester of DES exposure, the patient’s age, use of oral contraceptives, or presenting symptoms. Areas of punctation, mosaic patterns, white epithelium, and keratosis were not considered areas of adenosis. Cervical bands, hoods, cock’s combs, etc., were considered as part of the cervix. Under this definition adenosis of the vagina was diagnosed in only 14.1% of the patients. Eight (4.0%) women were found to have cervical intraepithelial neoplasia (CIN), Grade 3 lesions, and an additional 36 (14.1%) women were found to have CIN, Grade 1 lesions based on the light microscopy evaluation of directed biopsies. There were no cases of clear cell adenocarcinoma. It appears that women with in utero DES exposure may be at a higher risk of developing squamous neoplasia compared with non-DES-exposed women.

Sources and more information
  • In utero exposure to DES. Evaluation and followup of 199 women,
    NCBI PMID: 662229, Obstet Gynecol. 1978 Apr;51(4):459-63.
  • Vaginal and cervical squamous cell dysplasia in women exposed to diethylstilbestrol in utero,
    NCBI PMID: 717453, Am J Obstet Gynecol. 1978 Nov 1;132(5):537-44.
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BPA and DES exposure alters the epigenetic programming of the HOTAIR promoters

Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo

RNA-HOTAIR graphic
Models showing the roles of ERs, MLLs and other ER-coregulators during BPA and DES mediated endocrine disruption of HOTAIR. Steroidogenic EDCs like BPA and DES binds to ERs (ERα and ERβ), in a similar fashion to estradiol. Activated ERs… Image credit NCBI PMC4025971/figure/F7/.

2015 Study Abstract

Antisense transcript, long non-coding RNA HOTAIR is a key player in gene silencing and breast cancer and is transcriptionally regulated by estradiol. Here, we have investigated if HOTAIR expression is misregulated by bisphenol-A (BPA) and diethylstilbestrol (DES). Our findings demonstrate BPA and DES induce HOTAIR expression in cultured human breast cancer cells (MCF7) as well as in vivo in the mammary glands of rat. Luciferase assay showed that HOTAIR promoter estrogen-response-elements (EREs) are induced by BPA and DES. Estrogen-receptors (ERs) and ER-coregulators such as MLL-histone methylases (MLL1 and MLL3) bind to the HOTAIR promoter EREs in the presence of BPA and DES, modify chromatin (histone methylation and acetylation) and lead to gene activation. Knockdown of ERs down-regulated the BPA and DES induced expression of HOTAIR. In summary, our results demonstrate that BPA and DES exposure alters the epigenetic programming of the HOTAIR promoters leading to its endocrine disruption in vitro and in vivo.

It is important to note that, HOTAIR is an antisense transcript and lncRNA. Therefore, our studies also demonstrate that endocrine disruptors can disrupt the noncoding RNAs and can induce antisense transcripts, in a similar fashion as protein coding genes from the sense strands. Our studies revealed novel epigenetic mechanism of endocrine disruption, novel roles of MLL histone methylases and their coordination with ERs and various ER-coregulators during endocrine disruption, both in vitro and in vivo. Although further in vivo analyses are required to understand the detailed mechanism of HOTAIR gene expression and misregulation by EDCs, synthetics estrogens, and other environmental toxins/chemical, our observations indicate that exposure to BPA or DES may turn on the expression of HOTAIR in vivo, in a very similar fashion to estrogen even in the absence of estrogen, and that may result in adverse health effects including cancer and other hormonally regulated disorders.

Sources and more information
  • Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo, J Steroid Biochem Mol Biol. NCBI PMID: 24533973, 2014 May;141:160-70. doi: 10.1016/j.jsbmb.2014.02.002. Epub 2014 Feb 14.
  • Full text NIHMSID: NIHMS569531, PMCID: PMC4025971, 2015 May 1.
DES DiEthylStilbestrol Resources

Dr Frances Oldham Kelsey: 20th-century American heroine for her role in the Thalidomide case

Frances Oldham Kelsey, F.D.A. stickler who saved U.S. babies from Thalidomide, dies at 101

Dr-Frances-Oldham-Kelsey
Dr Frances Oldham Kelsey, the Canadian doctor who played a central role in preventing the drug thalidomide being distributed in the US, has died at 101. Image of Kelsey with President John F. Kennedy signing the 1962 Drug Amendments (FDA051) by the The U.S. Food and Drug Administration.

A Londoner who’s kept the scourge of thalidomide out of the United States has died, leaving behind a legacy of achievement that made her a heroine south of the border.

In 1962, President John F. Kennedy awarded Kelsey the highest honour given to a civilian in the U.S., the President’s Award for Distinguished Federal Civilian Service. Kelsey was only the second woman to receive the award. The new laws would pass and Kelsey would play a leading role giving them force.

Dr Frances Kelsey spent her final years here with family after a trail-blazing career that once led the Baltimore Post-Examiner to call her America’s greatest living heroine.

Sources and more information
  • Frances Oldham Kelsey, F.D.A. Stickler Who Saved U.S. Babies From Thalidomide,
    Dies at 101
    , NYtimes, AUG. 7, 2015.
  • Frances Oldham Kelsey – a true American hero turns 100,
    Baltimore Post-Examiner, July 26, 2014.
  • America’s Greatest Living Heroine Frances Oldham Kelsey – 98 and forgotten,
    Baltimore Post-Examiner, February 11, 2013.
  • Thalidomide and the 1962 Kefauver-Harris Drug Amendments, FDA.
  • About the life and work of Dr. Kelsey: Autobiographical Reflections, FDA.

The Custom-Made Child?

Women-Centered Perspectives (Contemporary Issues in Biomedicine, Ethics, and Society)

The-Custom-made-Child book cover image
Women-Centered Perspectives (Contemporary Issues in Biomedicine, Ethics, and Society)

Women most fully experience the consequences of human reproductive technologies. Men who convene to evaluate such technologies discuss “them”: the women who must accept, avoid, or even resist these technologies; the women who consume technologies they did not devise; the women who are the objects of policies made by men. So often the input of women is neither sought nor listened to. The privileged insights and perspectives that women bring to the consideration of technologies in human reproduction are the subject of these volumes, which constitute the revised and edited record of a Workshop on “Ethical Issues in Human Reproduction Technology: Analysis by Women” (EIRTAW), held in June, 1979, at Hampshire College in Amherst, Massachusetts. Some 80 members of the workshop, 90 percent of them women (from 24 states), represented diverse occupations and personal histories, different races and classes, varied political commitments. They included doctors, nurses, and scientists, lay midwives, consumer advocates, historians, and sociologists, lawyers, policy analysts, and ethicists. Each session, however, made plain that ethics is an everyday concern for women in general, as well as an academic profession for some.

DES DiEthylStilbestrol Resources

Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal DES exposure

Squamous cell abnormalities of the vagina and cervix were evaluated in 1424 women exposed to diethylstilbestrol (DES) in utero

dysplasia
These 1978 data suggest that both cytology and biopsy of abnormal segments of the vagina and cervix remain an integral part of the examination of the DES-exposed female during long-term follow-up . Image by Helga Weber.

1978 Study Abstract

Squamous cell abnormalities of the vagina and cervix were evaluated in 1424 women exposed to diethylstilbestrol (DES) in utero. The prevalence of dysplasia was 2.1% and the incidence 0.85/100 person-years of followup. The dysplastic epithelial changes were almost always mild in women with no prior history of dysplasia and was slightly more frequent in the cervix than the vagina. Severe dysplasia and carcinoma in situ (CIS) were encountered only in those subjects specifically referred because of those abnormalities. The most common problem in the diagnosis of these squamous cell changes was the misinterpretation of mature and immature metaplastic cells for dysplastic squamous cells. Discordance between biopsy and cytology was common-place in the detection and followup of dysplasia, especially when it was mild. There were no instances in the study where cytology and biopsy samples from the vagina were both abnormal concurrently. Colposcopically directed biopsies did not increase the frequency of confirmation of cytologic findings. These data suggest that both cytology and biopsy of abnormal segments of the vagina and cervix remain an integral part of the examination of the DES-exposed female during long-term follow-up studies.

Sources and more information
  • Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol,
    NCBI PMID: 652199, Obstet Gynecol. 1978 May;51(5):528-35.
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