Diethylstilbestrol DES-induced clear cell adenocarcinoma of the vagina metastasizing to the brain

Necessity of close extended follow-up in the DES-exposed

metastasizing-to-the-brain
This 2007 case report highlights the necessity of close extended follow-up in patients with a history of vaginal CCA and demonstrates the potential for spread of primary vaginal CCA to the brain.

2007 Study Abstract

BACKGROUND:
Primary vaginal clear cell adenocarcinoma (CCA) is a rare gynecological malignancy occurring predominantly in young females with a history of diethylstilbestrol exposure in utero. Vaginal CCA commonly metastasizes to the lungs and the supraclavicular lymph nodes; however we present a rare case of diethylstilbestrol-induced vaginal CCA with cerebral metastases.

CASE DESCRIPTION:
A 43-year-old woman with prenatal diethylstilbestrol exposure and history of vaginal CCA treatment 8 years prior to current presentation noted new onset headache and dizziness. MRI showed an enhancing mass in the right frontal lobe. Histopathology was consistent with CCA.

CONCLUSIONS:
This case report highlights the necessity of close extended follow-up in patients with a history of vaginal CCA and demonstrates the potential for spread of primary vaginal CCA to the brain.

Sources and more information
  • Diethylstilbestrol (DES)-induced clear cell adenocarcinoma of the vagina metastasizing to the brain, Gynecologic oncology, NCBI pubmed 17292458, 105(1):273-6. Epub 2007 Feb 8.
More DES DiEthylStilbestrol Resources

Author: DES Daughter

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.

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