It’s time to #ThinkBeforeYouPink, and stop breast cancer before it starts!
More info and videos
Think Before You Pink, a project of Breast Cancer Action, launched in 2002 in response to the growing concern about the overwhelming number of pink ribbon products and promotions on the market.
The campaign calls for more transparency and accountability by companies that take part in breast cancer fundraising, and encourages consumers to ask critical questions about pink ribbon promotions.
Infographic from the documentary “Pink Ribbons, Inc.” directed by Léa Pool that shows how the devastating reality of breast cancer, which marketing experts have labeled a “dream cause,” has been hijacked by a shiny story of success. Based on the book Pink Ribbons, Inc.: Breast Cancer and the Politics of Philanthropy by Samantha King.
Image sources: Breast Cancer Consortium, Graphics.
Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance
2015 Study Abstract
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape. This model associates the global properties of the fitness landscape with the algebraic properties of a Markov chain transition matrix and allows us to derive general results on the non-commutativity and irreversibility of natural selection as well as antibiotic cycling strategies. Using this formalism, we analyze 15 empirical fitness landscapes of E. coli under selection by different β-lactam antibiotics and demonstrate that the emergence of resistance to a given antibiotic can be either hindered or promoted by different sequences of drug application. Specifically, we demonstrate that the majority, approximately 70%, of sequential drug treatments with 2–4 drugs promote resistance to the final antibiotic. Further, we derive optimal drug application sequences with which we can probabilistically ‘steer’ the population through genotype space to avoid the emergence of resistance. This suggests a new strategy in the war against antibiotic–resistant organisms: drug sequencing to shepherd evolution through genotype space to states from which resistance cannot emerge and by which to maximize the chance of successful therapy.
Sources and more information
Moffitt Cancer Center Researchers Develop Novel Theoretical Approach to Reduce Antibiotic Resistance, moffitt, October 07, 2015.
Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance, PLOS one, DOI: 10.1371/journal.pcbi.1004493, September 11, 2015.
Gayle Sulik “Pink Ribbon BLues”, Siena College, 2010
Dr. Gayle Sulik, author of Pink Ribbon Blues: How Breast Cancer Culture Undermines Women’s Health, spoke at Siena College on October 26, 2010.
Medical sociologist Gayle A. Sulik’s book shows how advocacy, publicity, and mass marketing created a culture that transformed breast cancer from an important woman’s health problem in need of complicated social and medical solutions, to a popular item for public consumption.
” Ugh. here we go again. Another round of “Ssh don’t tell the boys, tee-hee” emails going around Facebook with ridiculous ideas about what to put on your status update under the premise of raising awareness of breast cancer. There’s so much wrong with this I actually get paralysed with rage when I think about it too much. ”
The age of the patients at diagnosis has varied from 7-35 years with the highest frequency from 14-22 years. The risk among the exposed, however, is small and is of the order of 1 per 1,000.
Almost all of the cases occur in postmenarchal females. Other factors that may increase the risk are maternal history of prior miscarriage, exposure to DES in early gestation, a fall season of birth and prematurity.
The occurrence of CCA has paralleled the sales of DES for pregnancy support in the U.S. Both vaginal adenosis (benign glands in the vagina) and CCA are more frequent among those whose mothers began DES in early pregnancy.
An increased risk of squamous cell neoplasia has been hypothesized but not proven. The changes that occur in the female genital tract of the DES exposed appear to result from alterations in the development of the mullerian ducts.
Currently there is not definitive evidence for an elevated risk of cancer among DES mothers or DES sons but studies have suggested a possible increase of breast cancer in the former group and testicular cancer in the latter group; a valid association has not been established in either.
Sources and more information
The effects in the human of diethylstilbestrol (DES) use during pregnancy, Princess Takamatsu Symposia 1987;18:67-75., NCBI PMID: 3506546.
Too much chemo. Too much radiation. And way too many mastectomies
“ What if I decide to just do nothing?
“It was kind of a taunt, Desiree Basila admits. Not the sort of thing that usually comes out of the mouth of a woman who’s just been diagnosed with breast cancer. For 20 minutes she’d been grilling her breast surgeon. “Just one more question,” she kept saying, and her surgeon appeared to her to be growing weary. She was trying to figure out what to do about her ductal carcinoma in situ (DCIS), also known as Stage 0 breast cancer, and she was already on her second opinion. The first surgeon had slapped a photograph of her right breast onto a viewer, pointed to a spot about 5 cm long and 2.5 cm wide and told her there was a slot open the following week for a mastectomy. “…
Dépistage cancer du sein : pour une réelle liberté de choix
Entretien du 20 octobre 2014 sur IDFM 98 Radio Enghien.
Vidéo publiée le 2 Nov 2014 par Joelle Verain.
Rachel Campergue , invitée de cette émission en décembre 2011 suite à la sortie de son premier ouvrage “No Mammo?– Enquête sur le dépistage du cancer du sein” où elle montrait, études scientifiques à l’appui, que le dépistage n’avait pas que des avantages, que les femmes n’étaient pas pleinement informées de ses inconvénients, et ne pouvaient donc pas décider en toute connaissance de cause, nous revient avec un second opus “Octobre rose mot à maux, Pour une réelle liberté de choix“: un manuel de décryptage de la campagne Octobre Rose, qui a très souvent recours aux mêmes procédés que dans la publicité.
American Journal of Obstetrics and Gynecology, 1979
1979 Study Abstract
Three hundred and eighty-four cases of clear cell adenocarcinoma of the vagina and cervix accessioned in the Registry as of December 31, 1978, have been analyzed.
The annual incidence of these tumors has been found to correspond closely to the estimated usage of diethylstilbestrol (DES) for pregnancy support in the United States. The annual incidence of the DES-associated cases appears to have dropped in the United States in the past 2 years in comparison to 1973 to 1975.
The risk of tumor development appears to be higher in young women exposed to DES early in intrauterine life than in those exposed later. The carcinomas are rare before the age of 14 years and an irregular peak in the age-incidence curve appears between 17 and 21 years followed by a decline.
The 5-year survival rate is better for women over the age of 19 years than for younger patients, and a higher frequency oral contraceptive usage did not appear to influence the behavior of the tumor and the improved survival in those using this medication appears to be related to greater medical surveillance.
Sources and more information
Epidemiologic aspects and factors related to survival in 384 Registry cases of clear cell adenocarcinoma of the vagina and cervix, American Journal of Obstetrics and Gynecology 1979 Dec 1;135(7):876-86, NCBI PMID: 507130.
This article reports on the findings of a qualitative study that explored the awareness and knowledge of male breast cancer among English-speaking men. The primary goal was to elicit information to guide both clinical practice and the development of gender-specific educational interventions.
Interviews with 28 adult men, all of whom had no history of breast cancer themselves but had at least one maternal blood relative with the disease, were conducted and analyzed, using qualitative methods, to describe participants’ awareness of male breast cancer, their knowledge of the disease, and how they thought awareness of male breast cancer could be increased in health care providers and the lay public.
Nearly 80% of participants weren’t aware that men can get breast cancer; and although all were at higher risk given their positive family history, all reported that their providers had never discussed the disease with them. A majority couldn’t identify any symptoms other than a lump in the breast. About 43% voiced concerns that a diagnosis of breast cancer would cause them to question their masculinity. Participants also suggested ways that men, as well as providers and the lay public, could be better made aware of and educated about their risk for this disease.
This study provides much-needed insight into men’s awareness and knowledge of male breast cancer. While further research with larger samples is needed, these findings offer a starting point for the development of evidence-based, gender-specific, health promotion and disease prevention interventions for men.