DiEthylStilbestrol Resources: Epigenetics and Transgenerational Effects

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Epigenetics

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NCBI PubMed DiEthylStilbestrol Resources: Epigenetics and Transgenerational Effects.

DES Transgenerational Effects

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Green pastures? comic strip about the need for safer chemicals

Taken from “Choosing our future” comic book, 2012 edition

How chemicals are harming our health – Page 3

Green-Pastures-3 comic strip
For a healthier life, consume chemicals in moderation! @HealthandEnv 2012.

Green pastures? the comic strip

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Sexual activity level and sexual functioning in women prenatally exposed to diethylstilbestrol

Well-established sex-partner relationships are less common for the DES-exposed

image of partner-relationship
Sexual activity level and sexual functioning in women prenatally exposed to diethylstilbestrol. Helen Taylor.

Study Abstract

Thirty women with a history of prenatal exposure to diethylstilbestrol (DES) underwent a detailed sexual history and were compared to a demographically similar sample of 30 women with a history of an abnormal Pap smear.

Psychosomatic medicine,
NCBI PMID: 4070521,
1985 Nov-Dec.

The DES women were found to have less well-established sex-partner relationships and less experience with child-bearing, to be lower in sexual desire and enjoyment, sexual excitability, and orgasmic coital functioning, but to be comparable (and low) with regard to such sexual dysfunctions as vaginismus and dyspareunia.

Both potential psychosocial and neuroendocrine explanations are discussed.

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DES Daughter Network Blog New Design

New header image, new WordPress theme and new colours for 2016!

With 2016 approaching, we thought it was time for few changes…

Fist, the header image. This “three wise doctors looking at us” awesome graphic is © and courtesy of Artist and DES awareness supporter Alberto Sebastiani.

You’ve been exposed to DES,
so what?

Some posts such as My DES Daughter Journey – Doctors (03.2011), Wanted: DES Aware Doctors (04.2011) and A focus group study of DES daughters: implications for health care providers (2000 study) mentioned the DES victims distrust of the medical profession. I cannot think of a better image to illustrate the DES cause.

Many thanks to Alberto for his long time support. Here are few links for you to visit Albertos’s blog, website and Twitter.

image of Responsive-design
WordPress says that theme Twenty Sixteen. will make your homepage look sharp on any device, and impeccable polish in every detail.

Fluid Design
and Responsive Images

Thank you theme comet for the years we spent together, from now on, we opted for the WordPress default theme for 2016: Twenty Sixteen.
Here are some of the theme new key features:

Introducing Twenty Sixteen

  • With or without sidebar, your call.
  • Overhang (the column) with a full-size image,wider than or equal to 840px.
  • Use the excerpt section to add a catchy, short post intro showing under your main header / post title.
  • Customize block quotes – put them left, right, where you like them!
  • Display links to your social media profiles with perfectly sized icons in the footer with a custom menu.
  • Add a call to action under your posts and pages, with 1 or 2 widgets displaying below your content.
  • For more information, visit the WordPress theme page and  demo version.

I can’t wait to get your opinion

Please tell me what you think, honestly, the good and bad…
Cheers

Green pastures? comic strip about the need for safer chemicals

Taken from “Choosing our future” comic book, 2012 edition

How chemicals are harming our health – Page 2

Green-Pastures-2 comic strip
For a healthier life, consume chemicals in moderation! @HealthandEnv 2012.

Green pastures? the comic strip

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The DES Manufacturer Identification Problem: A Florida Public Policy Approach

University of Miami Law, School Institutional Repository, 1986

The court must take some action that will encourage manufacturers to assure that their products are traceable back to themselves. To do otherwise will leave open a loophole through which manufacturers can escape liability for injuries sustained by their consumers. This result would be inconsistent with the court’s declared policy that “the law will step in to protect people against risks which they cannot adequately guard against themselves.”‘

3-1-1986 – Introduction

Terri Lynn Conley suffered from cervical adenosis.  She underwent surgery for removal of most of her cervix, as well as removal of other precancerous and cancerous tumors. Conley’s mother ingested the drug diethylstilbestrol (DES) twenty years before while Conley was present in utero. Doctors commonly prescribed DES as a miscarriage preventative around the time period that Conley’s mother was pregnant but subsequent research linked in utero exposure to DES to the kind of cancer that Conley developed.

Conley brought an action against eleven manufacturers who had produced DES both before and during her mother’s pregnancy. She alleged that the DES her mother ingested during pregnancy caused her own medical complications. She was unable to identify the specific manufacturer of the DES that her mother ingested but she suggested four alternative theories of recovery in lieu of the traditional tort requirement that the plaintiff identify specific tortfeasors.

The trial court granted motions to dismiss and judgments on the pleadings for the defendants because of Conley’s inability to identify the specific manufacturer. On appeal, the Fourth District Court of Appeal affirmed, held: failure to allege legal causation by identifying the specific tortfeasors precludes recovery. The district court recognized, however, the compelling argument in favor of relaxing the identification requirement in DES-like situations, and considered various theories fashioned by courts of other jurisdictions. The court proposed its own theory of liability for adoption in Florida, and urged its serious consideration by the supreme court. The court concluded, however, that it lacked authority to approve a new theory of liability before the Supreme Court of Florida had done so. It certified the following question to the supreme court as an issue of great public concern: “Does Florida recognize a cause of action against a defendant for marketing defective DES when the plaintiff admittedly cannot establish that a particular defendant was responsible for the injury?”

Conclusion

Confrontation with any traditional legal doctrine requires a thorough examination of the public policy considerations which are the substance of the law. The court must recognize the changes that have occurred in society, and if the scope of those changes is great enough, it must rework tort doctrine so that tort law can continue to serve its original purpose-that of making the public policies of society a reality in the everyday lives of individuals. This exercise is one of the essential roles courts play in the society they serve.

The Conley v. Boyle Drug Co. case will be a difficult decision for the Supreme Court of Florida. Only if the court relaxes the defendant identification requirement will Terri Lynn Conley have a remedy. Relaxation of the defendant identification requirement is consistent with the court’s policy of compensating injured plaintiffs for injuries caused by wrongs committed by others. It is also consistent with the policy of preferring innocent plaintiffs over possibly culpable defendants. Because the Conley case is a products liability action, the relaxation of the defendant identification requirement promotes the court’s policy of giving manufacturers the incentive to produce safe products. It is also consistent with the court’s recognition that manufacturers are better able than consumers to spread the risk of loss caused by defects in their products. The court must also recognize that the expanding use of generic drugs will inevitably cause the problem to occur again. The court must take some action that will encourage manufacturers to assure that their products are traceable back to themselves. To do otherwise will leave open a loophole through which manufacturers can escape liability for injuries sustained by their consumers. This result would be inconsistent with the court’s declared policy that “the law will step in to protect people against risks which they cannot adequately guard against themselves.“‘ By recognizing that Terri Lynn Conley is entitled to a remedy at law, the court will protect Florida citizens from similar incidents in the future.

Sources
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Antidepressant use during Pregnancy and the Risk of Autism Spectrum Disorder in Children

Taking antidepressants during pregnancy increases risk of autism by 87 percent

Taking antidepressants during pregnancy increases risk of autism by 87 percent. Some classes of antidepressants work by inhibiting serotonin (SSRIs and some other antidepressant classes), which will have a negative impact on the ability of the brain to fully develop and adapt in utero, Scott Roberts.

2015 Study Abstract

Importance
The association between the use of antidepressants during gestation and the risk of autism spectrum disorder (ASD) in children is still controversial. The etiology of ASD remains unclear, although studies have implicated genetic predispositions, environmental risk factors, and maternal depression.

Objective
To examine the risk of ASD in children associated with antidepressant use during pregnancy according to trimester of exposure and taking into account maternal depression.

Design, Setting, and Participants
We conducted a register-based study of an ongoing population-based cohort, the Québec Pregnancy/Children Cohort, which includes data on all pregnancies and children in Québec from January 1, 1998, to December 31, 2009. A total of 145 456 singleton full-term infants born alive and whose mothers were covered by the Régie de l’assurance maladie du Québec drug plan for at least 12 months before and during pregnancy were included. Data analysis was conducted from October 1, 2014, to June 30, 2015.

Exposures
Antidepressant exposure during pregnancy was defined according to trimester and specific antidepressant classes.

Main Outcomes and Measures
Children with ASD were defined as those with at least 1 diagnosis of ASD between date of birth and last date of follow-up. Cox proportional hazards regression models were used to estimate crude and adjusted hazard ratios with 95% CIs.

Results
During 904 035.50 person-years of follow-up, 1054 children (0.7%) were diagnosed with ASD; boys with ASD outnumbered girls by a ratio of about 4:1. The mean (SD) age of children at the end of follow-up was 6.24 (3.19) years. Adjusting for potential confounders, use of antidepressants during the second and/or third trimester was associated with the risk of ASD (31 exposed infants; adjusted hazard ratio, 1.87; 95% CI, 1.15-3.04). Use of selective serotonin reuptake inhibitors during the second and/or third trimester was significantly associated with an increased risk of ASD (22 exposed infants; adjusted hazard ratio, 2.17; 95% CI, 1.20-3.93). The risk was persistent even after taking into account maternal history of depression (29 exposed infants; adjusted hazard ratio, 1.75; 95% CI, 1.03-2.97).

Conclusions and Relevance
Use of antidepressants, specifically selective serotonin reuptake inhibitors, during the second and/or third trimester increases the risk of ASD in children, even after considering maternal depression. Further research is needed to specifically assess the risk of ASD associated with antidepressant types and dosages during pregnancy.

Sources and more information
  • Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children, JAMA Pediatrics, doi:10.1001/jamapediatrics.2015.3356, December 14, 2015.
  • Taking antidepressants during pregnancy increases risk of autism by 87 percent, medicalxpress, December 14, 2015.
  • Antidepressants during pregnancy linked to autism, medicalnewstoday, 14 December 2015.

Green pastures? comic strip about the need for safer chemicals

Taken from “Choosing our future” comic book, 2012 edition

How chemicals are harming our health – Page 1

No matter how old we are, where we live, or what we do, none of us can escape exposure to man-made chemicals in our everyday lives that threaten our health.

The unborn child and children are most at risk because they have fewer defences and longer periods of life ahead of them in which cancer and other health problems may emerge.

We are exposed through food and water, through cosmetics that we rub into our skin and through the fumes from cleaning products and polluted city air.

Green-Pastures-1 comic strip
For a healthier life, consume chemicals in moderation! @HealthandEnv 2012.

Green pastures? the comic strip

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Depression and diethylstilbestrol exposure in women

The Journal of Reproductive Medicine, 1987

image of Mental-Illness
In this 1987 study, there were significant differences between DES-exposed women and their unexposed sisters (sister controls) in major depression and major recurrent depression. Mental Illness.

1987 Study Abstract

Fifty women exposed to diethylstilbestrol (DES) in utero, 50 of their unexposed sisters (sister controls) and 43 women with abnormal Papanicolaou smears (population controls) were tested using the Diagnostic Interview Schedule to assess differences in depression and other kinds of psychologic impairment possibly associated with DES exposure.

There were significant differences between DES-exposed women and their sisters in major depression and major recurrent depression. Papanicolaou controls were more depressed in comparison to sister controls. However, there were no significant differences in depression between Papanicolaou controls and the DES exposed, suggesting that major and recurrent depressions are more likely to result from concern about reproductive and other gynecologic problems than from the hormonal effects of intrauterine exposure to DES. Differences in amphetamine abuse/dependence were also noted between the DES exposed and the sister controls.

Sources and more information
  • Depression and diethylstilbestrol exposure in women, The Journal of reproductive medicine, NCBI PMID: 3430493, 1987 Nov;32(11):847-50.
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U.S. Congress votes to Ban Microbeads in Cosmetics

The House Just Voted to Ban Those Tiny Pieces of Plastic in Your Toothpaste and Face Wash

Microbeads
New act would phase out the tiny pieces of plastic found in soap, toothpaste and body washes, which pollute waters and spread throughout the food chain.

Monday 7 DEcember 2015, the US House of Representatives voted to phase out microbeads, the little pieces of plastic that act as exfoliants in personal-care products ranging from face wash to toothpaste. The bill, which had been backed by a bipartisan committee, will now go to the Senate for approval.

The bill was introduced last year by Rep. Frank Pallone (D-N.J.) and would ban the use of synthetic microplastics in cosmetics by 2018.

Sources and more information

  • The House Just Voted to Ban Those Tiny Pieces of Plastic in Your Toothpaste, motherjones, Dec. 8, 2015.
  • Congress Votes To Ban Microbeads In Personal Care Products, hngn, Dec. 8, 2015.
  • US to ban soaps and other products containing microbeads, theguardian, 8 December 2015.
  • Congress to vote on bill to ban microbead hygiene products in US, theguardian, 18 November 2015.