Unforgettable Cinderella. Comic strip about the need for safe cosmetics

Taken from “Choosing our future” comic book, 2012 edition

Beware of certain cocktails! Page 1

We are exposed to a daily “cocktail” of different man-made chemicals, which may be more potent than just one chemical on its own.

Despite this daily multiple exposure, we have insufficient scientific information about the safety and impact of these chemicals on our health. But absence of proof of harm doesn´t mean that they are safe to use!

We have the right to know that products are safe and which chemicals are used in them.

Unforgettable-Cinderella comic strip image
For a healthier life, consume chemicals in moderation! @HealthandEnv 2012.

Unforgettable Cinderella, the comic strip

Sources
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Removal of endocrine disrupting compounds from wastewater using polymer particles

Nanomaterials and UV light can “trap” chemicals for easy removal from soil and water

MIT-Pollutant-Nano
Nanoparticles that lose their stability upon irradiation with light have been designed to extract endocrine disruptors, pesticides, and other contaminants from water and soils. The system exploits the large surface-to-volume ratio of nanoparticles, while the photoinduced precipitation ensures nanomaterials are not released in the environment. MIT News.

Abstract

Removal of endocrine disrupting compounds from wastewater using polymer particles, Water science and technology : a journal of the International Association on Water Pollution Research, NCBI PubMed PMID: 26744949, 2016.

This study evaluated the use of particles of molecularly imprinted and non-imprinted polymers (MIP and NIP) as a wastewater treatment method for endocrine disrupting compounds (EDCs).

MIP and NIP remove EDCs through adsorption and therefore do not result in the formation of partially degraded products. The results show that both MIP and NIP particles are effective for removal of EDCs, and NIP have the advantage of not being as compound-specific as the MIP and hence can remove a diverse range of compounds including 17-β-estradiol (E2), atrazine, bisphenol A, and diethylstilbestrol.

Removal of E2 from wastewater was also tested to determine the effectiveness of NIP in the presence of interfering substances and natural organic matter. Removal of E2 from wastewater samples was high and increased with increasing NIP. NIP represent an effective way of removing a wide variety of EDCs from wastewater.

Neonatal abstinence syndrome: opioid use in pregnancy puts infants at risk

Opioids in pregnancy: high prescribing rates have probably contributed to recent increases in neonatal abstinence syndrome

image of opioid use in pregnancy
Greater use of prescribed opioids among women during pregnancy has probably contributed to the rise in neonatal abstinence syndrome NAS,

Abstract

The steep increase in the number of opioid prescriptions dispensed in the United States has been associated with a parallel rise in their misuse, fatal overdoses, and heroin use. More recently, attention has been focused on the large increase in the number of infants born with neonatal abstinence syndrome (NAS). In the US, between 2000 and 2009, the incidence of NAS increased from 1.20 to 3.39 per 1000 live births, and between 2004 and 2013 the total percentage of days spent in intensive care because of NAS increased from 0.6% to 4.0%. The rise in NAS is also likely to be a consequence of increased opioid prescriptions—estimates indicate that 14-22% of pregnant women in the US receive an opioid prescription during their pregnancy—as well as an increase in the prevalence of opioid use disorders among pregnant women.

The lack of scientific information on the effects of opioids on fetal brain development, combined with their known association with NAS, indicates that opioids should be reserved for pregnant women with severe pain that cannot be controlled through more benign means, and ideally limited to a short term use. If long term use is unavoidable, such as for women in need of buprenorphine or methadone maintenance therapy for heroin addiction, then careful assessment and monitoring should be undertaken to minimise the risk of overdoses, NAS, and misuse.

Sources and more information
  • Opioids in pregnancy: High prescribing rates have probably contributed to recent increases in neonatal abstinence syndrome, BMJ 2016;352:i19, 12 January 2016.
  • Opioid use in pregnancy puts infants at risk, medicalnewstoday, 12 January 2016.
  • Concerns over prescribed opioid use among pregnant women, eurekalert, 12 January 2016.

High dose of vitamin C kills cancer cells in mice

Human trials unlikely because drug companies cannot patent vitamins

image of oranges
High-dose vitamin C can boost the cancer-killing effect of chemotherapy in the lab and mice. Orange.

Getting all stressed out by vitamin C

Few experimental cancer therapies have incited as much debate as vitamin C. Yet the mechanistic effect of vitamin C on cancer cells is still poorly understood. Yun et al. studied human colorectal cancer cells with KRAS or BRAF mutations and found that they “handle” vitamin C in a different way than other cells, ultimately to their detriment (see the Perspective by Reczek and Chandel). Because a certain receptor is up-regulated in the mutant cells, they take up the oxidized form of vitamin C (dehydroascorbate). This leads to oxidative stress, inactivation of a glycolytic enzyme required by the mutant cells for growth, and finally cell death. Whether the selective toxicity of vitamin C to these mutant cells can be exploited therapeutically remains unclear.

Abstract

More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations and are often refractory to approved targeted therapies. We found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C. This effect is due to increased uptake of the oxidized form of vitamin C, dehydroascorbate (DHA), via the GLUT1 glucose transporter. Increased DHA uptake causes oxidative stress as intracellular DHA is reduced to vitamin C, depleting glutathione. Thus, reactive oxygen species accumulate and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Inhibition of GAPDH in highly glycolytic KRAS or BRAF mutant cells leads to an energetic crisis and cell death not seen in KRAS and BRAF wild-type cells. High-dose vitamin C impairs tumor growth in Apc/KrasG12D mutant mice. These results provide a mechanistic rationale for exploring the therapeutic use of vitamin C for CRCs with KRAS or BRAF mutations.

Study and Press Releases
  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH, science, 11 Dec 2015.
  • High dose of vitamin C kills cancer cells in mice, arstechnica, Nov 18, 2015.
  • Vitamin C ‘gives chemotherapy a boost’, BBC News, 9 February 2014.
  • Research continues to confirm that high doses of vitamin C injections destroy cancer, but don’t expect to hear that from Big Pharma, newstarget.

Stop unecessary pesticide use in Bristol parks and streets

Living in the “Green Capital”, Bristolians really need to sort this out and move with the times

SPRAYING-MONSANTO-GLYPHOSATE banner image
STOP SPRAYING MONSANTO GLYPHOSATES ON BRISTOL’S STREETS AND PARKS!
SIGN THE PETITION!

TO: BRISTOL CITY COUNCIL & GEORGE FERGUSON, MAYOR OF BRISTOL

Please ban the spraying of Monsanto’s Roundup and other glyphosate herbicides on the streets and parks of Bristol.

Why is this important?

Bristol Council currently uses four glyphosate herbicides including Monsanto’s Roundup on our streets and parks. This is despite the fact that the World Health Organisation (WHO) has identified glyphosate as likely to cause cancer in humans. The WHO finding sits alongside a wealth of existing evidence that raises alarming questions marks over the long term safety of exposure to glyphosate both on its own and in combination with other chemicals found in formulas such as Roundup.

The use of glyphosates has already been banned or restricted in 8 countries. It is not acceptable that ourselves, our children and the animals we share this city with are being routinely exposed to these chemicals whether we like it or not.

If Bristol is to have any credentials as the current European Green Capital, it must exercise the precautionary principle and follow the example of cities such as Chicago, Paris and Rotterdam by banning this spraying in public places.

This is a matter of great importance for those of us who care about each other’s health and the health of our children, our cats, our dogs and all the flora and fauna of this city, of course including our beloved bees.

For more information see this article from The Bristol Cable.

There are viable safe alternatives to glyphosates. The Netherlands have outright banned glyphosates in public spaces and are using a hot water treatment instead. A hot water and foam method is also available in the UK and Bristol Council is already aware that this can be a more effective alternative than hot water on its own. Glyphosates are the cheapest option but we must send the message loud and clear that value is not just about price and that the health and safety issues around glyphosate render its ‘cheap and easy’ status irrelevant. Other effective methods may cost more in cash terms but represent far better value to local residents. Using a formula such as Roundup in our public spaces is simply unacceptable no matter how cheap and quick it makes the task of urban weed management.

Have your say and SIGN the petition!

2017 Update

Read Forget the vinegar, the real reek is inaction on glyphosates, thebristolcable, 31st January, 2017.

Can essential oils help children with ASD remain calmer during transition periods and sleep better?

Parents say essential oils help children with autism sleep, but is there proof?

essential-oil-study-for-asd
Parents often use essential oils on their children with autism to help them remain calm and sleep better. A scientific study is underway at The Ohio State University Wexner Medical Center’s Nisonger Center to see if there are actual benefits.

Parents Say Essential Oils Help Children With Autism Sleep, But Is There Proof? msn, 10/28/2015.

Transition periods are especially challenging for many children with autism spectrum disorder. One of the most problematic times of the day occurs when children make the transition from dinner to bedtime. Reports have indicated that up to three out of four children with autism spectrum disorder experience trouble falling asleep or staying asleep, and there are currently no Food and Drug Administration-approved medications for treating pediatric sleep problems.

But over the last few years, parents across the country have been sharing success stories about the use of essential oils. Lavender and sandalwood oils, along with vetiver and frankincense, have been said to help children with autism remain calmer during transition periods and to even sleep more soundly.

Can essential oils help children with autism? medicalxpress, January 11, 2016.

The Ohio State University Wexner Medical Center’s Nisonger Center has launched a randomized, double-blind crossover study comparing two different combinations of 18 essential oils to test which is the safest and most effective for improving quality of life, by increasing relaxation and enhancing sleep efficiency in children with autism spectrum disorder.

EPA’s first neonicotinoid assessment confirms risk to bees

EPA says chemical neonicotinoids can harm bee colonies in certain situations

image of honey-bee
A widely used neonicotinoid insecticide poses a risk to honey bees, EPA said.

The Environmental Protection Agency said today in a “pollinator risk assessment” that imidacloprid, a popular neonicotinoid pesticide, poses a significant risk to honeybees — but it failed to examine risks to nearly 4,000 North American native bees and all other pollinators, including imperiled butterflies, bats and birds.

” You can’t claim to do a ‘pollinator risk assessment’ and really only look at one pollinator, the honeybee,that’s not only cheating on the purpose of this work but also cheating the native bees, birds, butterflies and other species threatened by this pesticide. In fact, many of these other pollinators are even more vulnerable to neonicotinoids than honeybees. ”
said Lori Ann Burd, Environmental Health director at the Center for Biological Diversity “

Today’s analysis indicates that for some crop uses, honeybees can be exposed to imidacloprid at concentrations that negatively affect the health of the hive. But a recent Nature study found that wild bees are more sensitive to the acute toxic effects of neonicotinoids — specifically that neonicotinoid seed coatings reduce wild bee density, solitary bee nesting and bumblebee colony growth. The EPA did acknowledge that bumblebees are affected by the pesticide at much lower levels than honeybees, but it nonetheless failed to properly assess the risk.

Continue reading EPA Concludes Neonicotinoids Pose Risk to Bees, Fails to Analyze Other Pollinators, biologicaldiversity, January 6, 2016.

WSJ press release:EPA Says Insecticide May Pose Risk to Bees, Jan. 6, 2016.

Le Procès de Julien, Petit-Fils Distilbène

L’hormone qui frappe la 3ème génération : Julien, le fils de Sylvie LE COSSEC

rallumer-les-étoiles

Communiqué de presse

Il est grand temps de rallumer les étoiles, celles de l’espérance et de la confiance en l’avenir. Bientôt en mars 2016, le procès du Distilbène devant la justice, l’hormone qui a frappé la 3ème génération de la famille Le Cossec: Julien, leur fils aîné polyhandicapé.

Le 10 mars 2016 aura lieu le second procès de Sylvie Le Cossec contre le laboratoire UCB Pharma, à l’origine du scandale du Distilbène.
Ce procès devra considérer si l’exposition au Distilbène de Sylvie LE COSSEC est responsable de l’accouchement prématuré, qui lui-même explique de façon directe le handicap majeur dont souffre son fils Julien.

En mars 2014, le premier procès avait permis d’établir le lien de causalité entre la mère, qui avait pris ce médicament, et sa fille, Sylvie Le Cossec.
Elle était enfin reconnue comme victime.
Un complément d’expertise avait été ordonné par le tribunal pour valider le lien de causalité entre Sylvie Le Cossec, fille DES comme on les appelle, et son fils Julien, né prématurément et lourdement handicapé.

Ce premier procès fut aussi celui des responsables du laboratoire pharmaceutique UCB Pharma qui commercialisa, dès 1953, cette molécule malgré sa haute toxicité. En dépit des mises en garde, le laboratoire continua de commercialiser ce médicament pendant 25 ans.

Ce procès fut celui des détenteurs de l’autorité morale et opérationnelle qui n’ont pas respecté leur devoir élémentaire de protection de la santé des personnes.

Ainsi, dans cette optique, nous avons pleinement confiance en notre justice.

Le TGI de Nanterre aura à se prononcer sur la responsabilité d’UCB Pharma sur ce dossier touchant maintenant la 3ème génération de la famille LE COSSEC.

Pour rappel, Le Distilbène est une hormone de synthèse prescrite aux femmes entre 1950 et 1977 pour prévenir les fausses couches.

Le fabricant, UCB Pharma, a décidé de rendre publique sa contre indication en 1977, soit 6 ans après son interdiction aux Etats-Unis.

Handicap : le Distilbène devant la justice. L’hormone qui frappe la 3ème génération : Julien, le fils de Sylvie LE COSSEC.

Sylvie LE COSSEC, la mère de Julien accuse le Distilbène d’être à l’origine du handicap de son fils Julien. Le médicament a provoqué une malformation utérine chez Sylvie LE COSSEC. Cette exposition au Distilbène in utero est responsable de son accouchement prématuré à la suite de la rupture prématurée de la poche des eaux à 31 semaines.

Aujourd’hui, Julien souffre d’un handicap à 80%.

  • Il présente une paralysie cérébrale très sévère.
  • Il n’a pas d’autonomie pour les actes de la vie courante, il a besoin d’une assistance en permanence.
  • Il présente une pathologie orthopédique secondaire évolutive.
  • Julien a des capacités d’expression limitée, il ne fait pas de phrase et se limite à répéter des idées.
  • C’est un enfant de 2 ans dans le corps d’un adolescent de 17 ans.

2 grossesses pathologiques, un cancer de l’utérus, une vie de femme et de famille irréversiblement bouleversée. Sylvie le Cosseccontact média souhaite ardemment la reconnaissance du handicap de son fils Julien.

Elle pourra alors entamer un processus de reconstruction et gagner une certaine forme de liberté et de sérénité pour elle et sa famille.

Sources
Le Distilbène DES, en savoir plus

The Human Genome: a New Picture of Disease Genetics

“High risk” cell populations may be playing important roles in human disorders and diseases

Research in the University of Utah Gregg Lab is focused on understanding genetic and epigenetic pathways and neuronal circuits that influence motivated behaviors and susceptibility to mental illness.

Mental illnesses are extremely complex and involve both genetic and environmental factors that alter brain functions and behavioral drives.

The NIMH estimates that about one in four Americans suffer from a diagnosable mental disorder with nearly 6% suffering serious disabilities as a result, and that the total cost of serious mental illness in the US exceeds $317 billion per year.

THE UNIVERSITY OF UTAH

Cancer screening – does it save lives?

Healthcare providers are encouraged to be frank about the limitations of screening—the harms of screening are certain, but the benefits in overall mortality are not

Why cancer screening has never been shown to “save lives”—and what we can do about it, BMJ 2016;352:h6080,
06 January 2016.

The claim that cancer screening saves lives is based on fewer deaths due to the target cancer. Vinay Prasad and colleagues argue that reductions in overall mortality should be the benchmark and call for higher standards of evidence for cancer screening.
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