Anyone got any health problems after the HPV vaccination ?

Contact “TimeForAction”, a campaign group run by UK families for UK families

My daughter has developed health problems after receiving the Gardasil vaccine, what should I do ?

If your daughter has developed health problems after HPV vaccination, please get in touch with TimeForAction – a campaign group run by UK families for UK families. They’re campaigning hard to ensure that these health problems are properly acknowledged and investigated, that families are treated with compassion and respect within the health service and that there is educational support in place for the girls who are struggling to attend school on a full timetable.

TimeForAction is also calling for a full disclosure of all the potential risks associated with the HPV vaccination to be given to parents when seeking consent, in conjunction with a more accurate assessment of the stated benefits. For more information, visit TimeForAction website, call 07885 422690, email, tweet or use this form.

How big data’s big bias is bringing noise and conflicts to US drug regulation

Jeanne Lenzer investigates, The BMJ, July 2017

A little known private foundation to support FDA’s “regulatory science” takes money out of the FDA’s coffers to support analyses using levels of evidence recommended by industry; many of the foundation’s directors have financial links to the drug and device makers that the FDA regulates.

Overview
  • No drug risks identified
  • Reagan-Udall Foundation
  • Directors’ ties to industry
  • Panel stacking
  • Funding the foundation
  • Funding the Medical Evidence Development and Surveillance (IMEDS)
  • Light touch FDA

Big data can be used cautiously to examine real world outcomes and to improve surveillance of drug safety. For example, it has been used to identify overuse of some interventions and can show drug and device complications in real world settings rather than idealized controlled trials.

However, big data are a noisy mess, and analyses by entities with profit motives may identify spurious associations that support fast track approvals and indication creep (broadening the indications for drugs and devices).” …

continue reading Jeanne Lenzer investigation Big data’s big bias: bringing noise and conflicts to US drug regulation on The BMJ, 18 July 2017.

Comment lutter contre les maltraitances médicales ?

La violence médicale est-elle une exception et comment faire évoluer les pratiques de certains soignants ?

LA question que LE DÉBAT DE MIDI s’est mise sous la dent.

Source : Comment lutter contre les maltraitances médicales ?, France Inter, Le débat de midi du lundi 17 juillet 2017.

Les invités de l’émission LE DÉBAT DE MIDI

  • Dominique Dupagne
    médecin généraliste, spécialisé dans la santé et les forums médicaux
  • Marie-Hélène Lahaye
    juriste, blogueuse
  • Odile Buisson
    gynécologue obstétricienne

Quelques Tweets

We are more than the sum of our genes

Epigenetics between the generations : we inherit more than just genes

Epigenetic mechanisms modulated by environmental cues such as diet, disease or our lifestyle take a major role in regulating the DNA by switching genes on and off. It has been long debated if epigenetic modifications accumulated throughout the entire life can cross the border of generations and be inherited to children or even grand children. Now researchers from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg show robust evidence that not only the inherited DNA itself but also the inherited epigenetic instructions contribute in regulating gene expression in the offspring. Moreover, the new insights by the Lab of Nicola Iovino describe for the first time biological consequences of this inherited information. The study proves that mother’s epigenetic memory is essential for the development and survival of the new generation.

Abstract

Gametes carry parental genetic material to the next generation. Stress-induced epigenetic changes in the germ line can be inherited and can have a profound impact on offspring development. However, the molecular mechanisms and consequences of transgenerational epigenetic inheritance are poorly understood. We found that Drosophila oocytes transmit the repressive histone mark H3K27me3 to their offspring. Maternal contribution of the histone methyltransferase Enhancer of zeste, the enzymatic component of Polycomb repressive complex 2, is required for active propagation of H3K27me3 during early embryogenesis. H3K27me3 in the early embryo prevents aberrant accumulation of the active histone mark H3K27ac at regulatory regions and precocious activation of lineage-specific genes at zygotic genome activation. Disruption of the germ line–inherited Polycomb epigenetic memory causes embryonic lethality that cannot be rescued by late zygotic reestablishment of H3K27me3. Thus, maternally inherited H3K27me3, propagated in the early embryo, regulates the activation of enhancers and lineage-specific genes during development.

Sources
  • Epigenetics between the generations : researchers prove that we inherit more than just genes, Max-Planck-Gesellschaft, July 13, 2017.
  • Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition, sciencemag, DOI: 10.1126/science.aam5339, 14 Jul 2017.
  • Featured image © MPI of Immunobiology a. Epigenetics / F. ZenkEgg-cell of a female fruit fly with the egg cell in which H3K27me3 was made visible through green staining. This cell, together with the sperm, will contribute to the formation of the next generation of flies. In the upper right corner, a maternal and paternal pre-nucleus are depicted before their fusion during fertilization. The green colouration of H3K27me3 appears exclusively in the maternal pre-nucleus, indicating that their epigenetic instructions are inherited into the next generation.

Who has the “best” health system in the “developed” world ?

International Comparison Reflects Flaws and Opportunities for Better Health Care

Depends what you want, a recently published Commonwealth Fund report shows that the UK is the best for ease of access and efficiency. But it also shows the UK is among the worst for outcomes; in fact it’s next to bottom.

Now call me picky, but when I’m admitted somewhere I’d prefer to remain alive in a hospital that maybe a little inefficient than die in an efficient one.

Martin Townsend.

ABSTRACT

ISSUE
The United States health care system spends far more than other high-income countries, yet has previously documented gaps in the quality of care.

GOAL
This report compares health care system performance in Australia,
Canada, France, Germany, the Netherlands, New Zealand, Norway,
Sweden, Switzerland, the United Kingdom, and the United States.

METHODS
Seventy-two indicators were selected in five domains: Care Process, Access, Administrative Efficiency, Equity, and Health Care Outcomes. Data sources included Commonwealth Fund international surveys of patients and physicians and selected measures from OECD, WHO, and the European Observatory on Health Systems and Policies. We calculated performance scores for each domain, as well as an overall score for each country.

KEY FINDINGS
The U.S. ranked last on performance overall, and ranked last or near last on the Access, Administrative Efficiency, Equity, and Health Care Outcomes domains. The top-ranked countries overall were the U.K., Australia, and the Netherlands. Based on a broad range of indicators, the U.S. health system is an outlier, spending far more but falling short of the performance achieved by other high-income countries. The results suggest the U.S. health care system should look at other countries’ approaches if it wants to achieve an affordable highperforming health care system that serves all Americans.

Sources and Press Releases
  • Mirror, Mirror 2017: International Comparison Reflects Flaws and Opportunities for Better U.S. Health Care, commonwealthfund, JULY 2017.
  • Appendices – Mirror, Mirror 2017: International Comparison Reflects Flaws and Opportunities for Better U.S. Health Care, commonwealthfund, JULY 2017.
  • UK has best health system in developed world, US analysis concludes, The BMJ 2017;358:j3442, 14 July 2017.
  • HOW BAD IS U.S. HEALTH CARE? AMONG HIGH-INCOME NATIONS, IT’S THE WORST, STUDY SAYS, newsweek, 7/14/17.

Les perturbateurs endocriniens affectent le développement du cerveau

Barbara Demeneix, chercheuse, 2017

La chercheuse Barbara Demeneix, biologiste au Muséum national d’Histoire naturelle, nous explique dans cet entretien l’influence des perturbateurs endocriniens sur le développement du cerveau de l’enfant. Pour détecter les perturbateurs endocriniens, cette scientifique utilise des têtards qui changent de couleur en fonction de la présence de polluants.

Des scientifiques avaient alerté, le 16 juin dernier, les vingt-huit ministres européens chargés de l’environnement sur la faiblesse du projet de réglementation européenne de ces polluants. Pour Barbara Demeneix, il y a urgence à agir.

En Savoir Plus
  • Le livre de Barbara Demeneix: Toxic Cocktail, How chemical pollution is poisoning our brains. A HEAL book review, May 2017. Sur Facebook.
Perturbateurs Endocriniens

Assessment of the biodegradability of selected sulfa drugs in two polluted rivers in Poland

Effects of seasonal variations, accidental contamination, turbidity and salinity

Up to 90% of consumed drugs enter the environment. This may have negative effects on wildlife, especially when the drugs take long periods to break down. This study assessed the breakdown of sulphonamides — a class of antibacterials — in samples from two rivers in Poland. The results showed that sulphamethoxazole, a common veterinary antibiotic, was the most persistent and that various factors inhibit degradation, including low temperatures, heavy metal pollution and low pH.

Highlights

  • Biodegradation rate of sulfonamides (SNs) in river water is variable.
  • Biodegradability of SNs depends on the growing season.
  • High concentration of salts in river water inhibits the SNs biodegradation.
  • Sulfamethoxazole could be classified as Persistent Organic Pollutant (POP).

Abstract

Which factors make drugs persistent? A look at sulphonamides in Polish rivers, Science for Environment Policy, 12 January 2017.

Assessment of the biodegradability of selected sulfa drugs in two polluted rivers in Poland: Effects of seasonal variations, accidental contamination, turbidity and salinity, science direct, August 2016.

Image credit Janusz Nowak.

The aim of our study was to assess the aerobic biodegradation of four selected sulfonamides (sulfanilamide, sulfamethoxazole, sulfadiazine and sulfathiazole) using water samples drawn from highly polluted rivers. Additionally, we aimed to identify the factors that have a significant effect on the process efficiency.

The 19 water samples were collected from Brynica and Czarna Przemsza rivers (in Poland) at the same location at approximately monthly intervals. A characteristic feature of the results is the presence of significant differences between the rates of sulfonamides biodegradation in particular samples.

The sulfonamide most resistant to biodegradation was sulfamethoxazole, whereas sulfathiazole was most biodegradable. Seasonal variations and related microbial population changes had the most significant effects on sulfonamides biodegradation, e.g., the studied process was highly inhibited during wintertime. A decrease in the biodegradation rate in the river water could be caused by an accidental water pollution by industrial wastewater with heavy metals, an increase in salinity and a decrease in pH, and turbidity.

Herbicide found in German estuaries, transported to the Baltic Sea

Glyphosate and AMPA in the estuaries of the Baltic Sea method optimization and field study

Glyphosate is a widely used herbicide, able to kill a broad range of plants (‘weeds’) that compete with crops. This study used a validated method to assess its presence in 10 German estuaries that lead to the Baltic Sea. All but one was contaminated with glyphosate, and all were contaminated with its metabolite AMPA. The researchers recommend risk assessments for these chemicals in the Baltic Sea and other marine environments.

Highlights

  • An LC–HESI-MS/MS method for glyphosate and AMPA analysis in estuarine water
  • Contamination of the Baltic estuaries with glyphosate and AMPA
    Glyphosate and AMPA concentrations exceed the European guideline of 100 ng/L.
  • The first study on transport glyphosate and AMPA from land to sea
  • Glyphosate concentrations may cause a toxic effect in some Baltic rivers and estuaries.

Abstract

Herbicide found in German estuaries, transported to the Baltic Sea, Science for Environment Policy, 25 November 2016.

Glyphosate and AMPA in the estuaries of the Baltic Sea method optimization and field study, science direct, November 2015.

Muta @ the Baltic Sea by Satorare.

Water samples from ten German Baltic estuaries were collected in 2012 in order to study the presence of the herbicide glyphosate, its primary metabolite AMPA and their potential transport to the marine environment. For the analyses an LC–MS/MS based analytical method after derivatization with FMOC-Cl was optimized and validated for marine water samples. All investigated estuarine stations were contaminated with AMPA and nine of them also with glyphosate. Concentration ranges observed were 28 to 1690 ng/L and 45 to 4156 ng/L for glyphosate and AMPA, respectively with strong spatial and temporal fluctuations. Both contaminants were found at inbound sampling sites in the stream Muehlenfliess and concentrations decreased along the salinity gradient to the estuaries of the Baltic Sea. The data obtained in this study clearly depict the transport of glyphosate and AMPA to the Baltic Sea. Hence, detailed fate and risk assessment for both contaminants in marine environments are required.

Stibrol

Diethylstilbestrol Injection via Indiamart, India

image of stibrol
DES use for livestock “growth”, weight-gain …

DES was/is still sold under many names including Distilbène®, Stilbetin®, Stilboestrol-Borne®, Benzestrol®, Chlorotrianisene®, Estrobene® and Estrosyn® to name just a few.

Many different companies manufactured and marketed this drug under more than 200 different brand names.

This Stibrol Diethylstilbestrol Injection U.S.P. is sold by Kunj Pharma Private Limited, Chandni Chowk, New Delhi, Delhi, India.

DES Drugs Pictures
DES DiEthylStilbestrol Resources

Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism

Autism: Which children respond to oxytocin treatment ?

Oxytocin treatment has been proven efficient in improving the social behavior of some children with autism, studies have found. A new clinical trial investigates which children will respond best to this treatment and why.

Abstract

Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in part, because existing medications target only associated ASD features. Emerging evidence suggests that the neuropeptide oxytocin (OXT) may be a blood-based biomarker of social functioning and a possible treatment for ASD. However, prior OXT treatment trials have produced equivocal results, perhaps because of variability in patients’ underlying neuropeptide biology, but this hypothesis has not been tested. Using a double-blind, randomized, placebo-controlled, parallel design, we tested the efficacy and tolerability of 4-wk intranasal OXT treatment (24 International Units, twice daily) in 32 children with ASD, aged 6–12 y. When pretreatment neuropeptide measures were included in the statistical model, OXT compared with placebo treatment significantly enhanced social abilities in children with ASD [as measured by the trial’s primary outcome measure, the Social Responsiveness Scale (SRS)]. Importantly, pretreatment blood OXT concentrations also predicted treatment response, such that individuals with the lowest pretreatment OXT concentrations showed the greatest social improvement. OXT was well tolerated, and its effects were specific to social functioning, with no observed decrease in repetitive behaviors or anxiety. Finally, as with many trials, some placebo-treated participants showed improvement on the SRS. This enhanced social functioning was mirrored by a posttreatment increase in their blood OXT concentrations, suggesting that increased endogenous OXT secretion may underlie this improvement. These findings indicate that OXT treatment enhances social abilities in children with ASD and that individuals with pretreatment OXT signaling deficits may stand to benefit the most from OXT treatment.

  • Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism, PNAS 1705521114, June 6, 2017.
  • Autism: Which children respond to oxytocin treatment?, medicalnewstoday, 2 July 2017.