Prenatal and postnatal bisphenol A exposure and social impairment in 4-year-old children

BPA linked to social deficits in offspring, particularly in girls

image of 4-year-old girl

2017 Study Abstract

Background
Prenatal and postnatal exposure to bisphenol A (BPA) may affect early brain development. Rodent studies suggest that prenatal and postnatal neurodevelopmental toxicity from BPA exposure may manifest as social deficits in offspring. We investigated the association between prenatal and postnatal exposure to BPA and social impairments in a sample of 4-year-old children.

Methods
We recruited second-trimester pregnant women between 2008 and 2011, and measured their creatinine-adjusted prenatal urine BPA levels. In 2014-2015, a subset of 4-year-old children born to these women underwent neurobehavioral assessment and physical examination. We collected urine and blood from the children and assessed social impairments, including deficits in social interaction, social communication, and other behavior patterns using the Korean version of the Social Communication Questionnaire (K-SCQ) (n = 304). We examined social impairments associated with prenatal exposure at mid-term pregnancy and postnatal exposure to BPA at 4 years of age, using linear and piecewise linear regression models.

Results
The relationship between prenatal BPA exposure and social communication was non-linear and statistically significant at or above the flexion point for BPA levels of 3.0 μg/g creatinine in girls (58.4%, 95% confidence interval [CI], 6.5% to 135.8%). Each 2-fold increase in postnatal BPA exposure was significantly associated with an 11.8% (95% CI, 0.6% to 24.3%) increase in impairment in social communication in 4-year old girls, as indicated by the linear regression model.

Conclusion
Prenatal and postnatal BPA exposure is associated with social impairment at 4 years of age, particularly in girls.

The prospective cohort study design is a strength of this study investigating the relationships between prenatal and postnatal BPA concentrations and social impairments at 4 years of age. Although the study has several limitations, including parent-reported questionnaires to evaluate social impairments and no participants with severe social impairments, the study makes a significant contribution to research on endocrine disruptors’ impact on children health because the relationship between BPA exposure and neurodevelopmental effects has not been fully elucidated in humans, and our results elucidate BPA exposure effects related to social impairments. Specifically, prenatal BPA exposure was significantly associated with impairments at or above the flexion point of 3.0 μg/g creatinine, whereas there was a linear association for postnatal BPA exposure. Further studies to evaluate the health implications and underlying mechanisms of these findings are warranted.

4 years old girl featured image credit kiwi huang.

Author: DES Daughter

Activist, blogger and social media addict committed to shedding light on a global health scandal and dedicated to raise DES awareness.

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