60 MiNueTs Toxic

UCSF Program on Reproductive Health and the Environment, 2017

Video published on 18 Apr 2019 by the UCSF Program on Reproductive Health and the Environment.

The University of California San Francisco (UCSF) Program on Reproductive Health and the Environment (PRHE)’s mission is to create a healthier environment for human reproduction and development through advancing scientific inquiry, clinical care and health policies that prevent exposures to harmful chemicals in our environment.

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PFAS chemicals found in biodegradable food containers can leach out and build up in compost

A worrisome class of chemicals called PFAS are found in some compostable food containers and many other consumer items like nonstick cookware. The compounds can leach out of the containers and build up in compost

Perfluoroalkyl Acid Characterization in U.S. Municipal Organic Solid Waste Composts

Abstract

Composting the organic fraction of municipal solid waste (OFMSW) creates a nutrient rich soil amendment and reduces the amounts of wastes going to landfills or incineration. However, the occurrence and fate of persistent and challenging per- and polyfluoroalkyl substances (PFAS) in OFMSW composts have not been well studied.

The loads and leachability of 17 perfluoroalkyl acids (PFAAs) were analyzed in nine OFMSW commercial composts and one backyard compost. PFAA loads ranged from 28.7 to 75.9 μg/kg for OFMSW composts that included food packaging and from 2.38 to 7.60 μg/kg for composts that did not include food packaging. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) were detected in all composts; however, OFMSW composts were dominated by short-chain PFAAs (>64%) and perfluoroalkyl carboxylates (PFCAs, >68%), particularly the C6 PFCA. The total oxidizable precursor assay indicated the presence of PFAS precursors in three OFMSW composts for which 6:2 fluorotelomer sulfonate and 6:2 dipolyfluoroalkyl phosphate ester were identified. Of the total PFAA load in the composts, 25–49% was released to porewater (∼1 g/2 mL). PFAA porewater concentrations versus PFAA loads as well as organic carbon-normalized sorption coefficients versus the number of PFAA CF2 units are strongly correlated (R2 > 0.85).

Study. Press release. Image.

Adult and Prenatal Chemical Exposures

Breast Cancer Prevention Partners, with Tracey Woodruff, Ph.D., Mar 2019

  • How am I exposed to chemicals?
  • What are prenatal exposures?
  • How can I reduce my own personal exposures?
  • What more can I do to help make a change?

Featuring BCPP Science Advisory Panel member Tracey Woodruff, Ph.D., Director of the Program on Reproductive Health and the Environment, University of California, San Francisco, Professor in the Department of Obstetrics, Gynecology, and Reproductive Sciences and Philip R. Lee Institute for Health Policy Studies at UCSF

La psychiatrie conserve une place importante dans les parcours de transition des personnes transgenres

Transidentité: la difficile question de la psychiatrie dans les parcours de transition

Pour débuter une thérapie hormonale, un examen psychiatrique est presque systématique en milieu hospitalier.
S’ensuit un passage devant une commission pluridisciplinaire, composée d’un psychiatre, d’un endocrinologue, ou encore d’un chirurgien.

La communauté scientifique spécialisée “s’accorde bien heureusement pour affirmer” que la “variance de genre” n’est pas une pathologie.

Dry olive leaf extract attenuates DNA damage induced by DES in human peripheral blood cells in vitro

The protective potential of dry olive leaf extract could arise from the synergistic effect of its scavenging activity and enhancement of the cells’ antioxidant capacity

2018 Study Highlights

  • Antigenotoxic potential of DOLE was investigated on the human whole blood in vitro, using comet assay.
  • E2 and DES were used as DNA damage inducers, expressing a genotoxic effect.
  • DOLE exhibited antigenotoxic properties.

Abstract

Phenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties.

Dry olive (Olea europaea L.) leaf extract is known to contain bioactive and antioxidative components and to have an ability to modulate the effects of various oxidants in cells.

The main goal of this study was to investigate antigenotoxic potential of a standardized dry olive leaf extract on DNA damage induced by 17β-estradiol and diethylstilbestrol in human whole blood cells in vitro, using comet assay.

Our results indicated that both hormones showed a genotoxic effect at a concentration of 100 μM (P < 0.05, n = 6).

Dry olive leaf extract was efficient in reducing number of cells with estrogen-induced DNA damage at tested concentrations (0.125, 0.5 and 1 mg/mL) (P < 0.05, n = 6) and under two experimental protocols, pre-treatment and post-treatment, exhibiting antigenotoxic properties.

Analysis of antioxidant properties of the extract revealed moderate ABTS radical scavenging properties and reducing power.

Overall, our results suggested that the protective potential of dry olive leaf extract could arise from the synergistic effect of its scavenging activity and enhancement of the cells’ antioxidant capacity.

DES DiEthylStilbestrol Resources

Substances toxiques : la mainmise des entreprises sur la réglementation

Peut-on dire que les firmes ont le permis de nous empoisonner ?

Le sociologue Henri Boullier, auteur de “Toxiques légaux” était l’invité de “L’entretien de l’intelligence économique” sur France 24.

Les gouvernements ont beau multiplier les réglementations, ils ne parviennent pas à interdire les produits toxiques pour la santé et pour l’environnement, et semblent incapables de résister aux pressions du marché.

Vidéo publiée le 27 mars 2019.

Bad Diets Are Responsible For More Deaths Than Smoking, Global Study Finds

About 11 million deaths a year are linked to poor diet around the globe

Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Summary

Background
Suboptimal diet is an important preventable risk factor for non-communicable diseases (NCDs); however, its impact on the burden of NCDs has not been systematically evaluated. This study aimed to evaluate the consumption of major foods and nutrients across 195 countries and to quantify the impact of their suboptimal intake on NCD mortality and morbidity.

Methods
By use of a comparative risk assessment approach, we estimated the proportion of disease-specific burden attributable to each dietary risk factor (also referred to as population attributable fraction) among adults aged 25 years or older. The main inputs to this analysis included the intake of each dietary factor, the effect size of the dietary factor on disease endpoint, and the level of intake associated with the lowest risk of mortality. Then, by use of disease-specific population attributable fractions, mortality, and disability-adjusted life-years (DALYs), we calculated the number of deaths and DALYs attributable to diet for each disease outcome.

Findings
In 2017, 11 million (95% uncertainty interval [UI] 10–12) deaths and 255 million (234–274) DALYs were attributable to dietary risk factors. High intake of sodium (3 million [1–5] deaths and 70 million [34–118] DALYs), low intake of whole grains (3 million [2–4] deaths and 82 million [59–109] DALYs), and low intake of fruits (2 million [1–4] deaths and 65 million [41–92] DALYs) were the leading dietary risk factors for deaths and DALYs globally and in many countries. Dietary data were from mixed sources and were not available for all countries, increasing the statistical uncertainty of our estimates.

Interpretation
This study provides a comprehensive picture of the potential impact of suboptimal diet on NCD mortality and morbidity, highlighting the need for improving diet across nations. Our findings will inform implementation of evidence-based dietary interventions and provide a platform for evaluation of their impact on human health annually.

Carey Gillam on Monsanto Lawsuit

The legal picture and the bigger picture, MARCH 29, 2019

How much power will we grant profit-driven corporations to determine not just what we’re exposed to, but what we’re permitted to know about it ?

Carey Gillam, longtime journalist, is currently research director at the group US Right to Know, and author of the book Whitewash: The Story of a Weedkiller, Cancer and the Corruption of Science.

Reference.

Vaccin Gardasil : vers un nouveau scandale sanitaire ?

Drs Nicole & Gérard Delépine, Culture Populaire, 1/2

Vidéo publiée le 28 février 2019. (Suite de 1/2).

Gérard Délépine chirurgien, oncologue et statisticien et Nicole Délépine, pédiatre, oncologue, se battent depuis plus de 40 ans pour améliorer la prise en charge des malades atteints de cancer et informer la population sur l’état actuel de la science en se basant sur les faits avérés, les registres nationaux des cancers et publications internationales.

Le Gardasil, vaccin contre le papillomavirus, a pour objectif officiel de diminuer la fréquence des cancers du col utérin dans les populations vaccinées. Pourtant ce cancer est rare (moins de 3000 par an en France, pour 1000 décès) et prévenu à plus de 80 % par le dépistage.

Quand aucune urgence de santé publique n’existe, pourquoi les agences du médicament accordent-elles des autorisations à toute allure, comme s’il s’agissait de maladies gravissimes ? Pourquoi le Gardasil a-t-il été traité comme un produit d’urgence vitale et bénéficié d’une publicité et d’un soutien massif des sociétés savantes, des experts et des gouvernants ? Pourquoi chaque jour apporte un nouvel article publicitaire trompeur dans les grands médias ? Pourquoi des députés déposent-ils un amendement pour rendre ce vaccin obligatoire ? Pourquoi tant d’émissions répandent-elles la peur chez les familles des jeunes femmes, et bientôt des garçons ?

Autant de questions auxquelles tente de répondre cet ouvrage, en faisant le bilan à 12 ans de la commercialisation sur les résultats avérés, et mettant en lumière la réalité des résultats des vaccinations larges et les confrontant aux espoirs des inconditionnels du vaccin, bercés d’illusions par les modélisations et simulations sur des hypothèses qui s’avèrent fausses. Ces résultats confirment la découverte de Lars Anderson sur la population suédoise : contrairement aux espoirs et simulations statistiques, le nombre de cancers du col utérin a augmenté chez les populations vaccinées.

Ainsi, en l’absence de prise de conscience rapide et mondiale, le Gardasil pourrait bien être le prochain scandale sanitaire, bien plus grave par son ampleur que ceux du Distilbène, du Vioxx, de la Dépakine ou encore du Médiator.

EDC-Mix Risk policy brief

Key messages on the risks of exposure to mixtures of endocrine disrupting chemicals

Safe chemicals for future generations

EDC-MixRisk is an EU project designed to ultimately lead to a safer environment for our children, an environment where the next generation can grow old without their quality of life being threatened by environmental chemicals or their mixtures.

The endocrine disrupting properties of chemicals, and mixtures thereof, have become a global concern. A normally functioning healthy endocrine system is essential for our ability to reproduce and develop. Endocrine disrupting chemicals (EDCs) are linked to serious health problems such as diabetes, obesity, neurodevelopmental disorders and reproductive problems. The fact that we are exposed to complex mixtures of EDCs is of particular concern.

EDC-MixRisk is an EU Horizon 2020 research project that studied the effects of prenatal exposure to mixtures of suspected EDCs on the development and health in children. Our work emphasises potential effects of EDC mixtures during foetal development and provides new tools and approaches for mixture risk assessment.

Key findings

  • Chemicals identified in pregnant women within the general population originated from different sources and application areas which are currently regulated by different pieces of European Union legislations.
  • Epidemiological analysis showed that prenatal exposure to mixtures of EDCs was associated with various effects in children’s health and development. Some effects were sex specific.
  • The tested mixtures affected hormone-regulated and disease-relevant outcomes in a variety of experimental models at the same concentrations found in the pregnant women.
  • Applying our novel whole mixture approach indicates a higher risk for children compared to risk estimated by current methods based on a single compound assessment.

Read the full EDC-MixRisk policy brief on edcmixrisk.ki.se, 2019.
Read the press release, 26 March, 2019.