Bisphenol A (BPA) is a component of polycarbonate and other plastics including resins that line food and beverage containers. BPA is known to leach from products in contact with food and drink, and is therefore thought to be routinely ingested. In a recent cross sectional study, BPA was detected in urine samples from 92.6% of the US population examined. The potential for BPA to influence body weight is suggested by in vitro studies demonstrating effects of BPA on adipocyte differentiation, lipid accumulation, glucose transport and adiponectin secretion. Data from in vivo studies have revealed dose-dependent and sex dependent effects on body weight in rodents exposed perinatally to BPA. The mechanisms through which perinatal BPA exposure acts to exert persistent effects on body weight and adiposity remain to be determined. Possible targets of BPA action are discussed.
BPA as an estrogen
BPA’s actions as an estrogen may contribute to effects on body weight. Sex-dependent and dose-dependent differences in body weight in response to early postnatal exposure to DES, an estrogenic compound with structural similarities to BPA have been reported. Those studies demonstrated increased body weight at 4 months of age in females exposed to DES (1 μg DES/day) from postnatal days 1 through 5. In contrast, males exposed to DES during that time period demonstrated a decrease in body weight relative to controls at 4 months of age. The administration of another estrogenic compound, the soy isoflavone, genistein to 4 week old male and female mice (in doses of 50–200,000 μg/kg/day for 15 days) also revealed dose and sex-dependent effects on adipose tissue deposition. In this specific paradigm, the males proved to be more sensitive to the effects of genistein showing increased adipose tissue deposition following treatment with nutritional doses of genistein and a significant decrease in fat pads when they were treated with pharmacological doses of the compound. It is intriguing to note that continuous exposure of male mice from conception through adulthood to a high phytoestrogen diet (containing high levels of genistein as well as diadzein) resulted in decreased adiposity, increased energy expenditure, and improved glucose and lipid metabolism. These data further suggest the importance of the dose and the precise timing of exposure to estrogenic compounds as well as the compounds themselves in determining their effects on adiposity and glucose homeostasis.
- Read Bisphenol A: Perinatal Exposure and Body Weight
NCSI, March 9 2009.
- After watching “Bisphenol A explained on Video… What is BPA and where is it used?“, you can go more in depth and find all you need to know about the endocrine disruptor BPA. The 2nd paragraph covers the similarities between BPA and DES!
- Find out more about BPA – BPS – Endocrine disruptors.
DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.