Can Brain Scans diagnose Autism accurately?

Brain activity analysis in response to social words such as “hug”

Right now, diagnosing disorders like autism relies heavily on interviews and behavioral observations. But scientists from Pittsburgh’s Carnegie Mellon University have shown that a much more objective measure – reading a person’s thoughts through an fMRI brain scan – might be able to diagnose autism with close to perfect accuracy…


Brain scan activity image
The researchers could distinguish “autism” from “not autism” (control) in 33 of 34 study participants, by using computerized analysis of brain scans showing activity in response to social words such as “hug.”

Autism is a psychiatric / neurological condition in which alterations in social interaction (among other symptoms) are diagnosed by behavioral psychiatric methods. The main goal of this study was to determine how the neural representations and meanings of social concepts (such as to insult) are altered in autism. A second goal was to determine whether these alterations can serve as neurocognitive markers of autism. The approach is based on previous advances in fMRI analysis methods that permit (a) the identification of a concept, such as the thought of a physical object, from its fMRI pattern, and (b) the ability to assess the semantic content of a concept from its fMRI pattern. These factor analysis and machine learning methods were applied to the fMRI activation patterns of 17 adults with high-functioning autism and matched controls, scanned while thinking about 16 social interactions. One prominent neural representation factor that emerged (manifested mainly in posterior midline regions) was related to self-representation, but this factor was present only for the control participants, and was near-absent in the autism group. Moreover, machine learning algorithms classified individuals as autistic or control with 97% accuracy from their fMRI neurocognitive markers. The findings suggest that psychiatric alterations of thought can begin to be biologically understood by assessing the form and content of the altered thought’s underlying brain activation patterns.

Sources and more information
  • Identifying Autism from Neural Representations of Social Interactions: Neurocognitive Markers of Autism,
    PLOS one, DOI: 10.1371/journal.pone.0113879, December 2, 2014.
  • Can a Brain Scan Diagnose Autism?
    autismspeaks, December 03, 2014.
  • How Brain Scans Can Diagnose Autism With 97% Accuracy,
    Time, Dec. 2, 2014.
  • Researchers: Brain activity can help predict autism,
    mcall, Dec. 2, 2014.

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