Diethylstilbestrol Clear Cell Adenocarcinoma Vaginal Cancer

Elevated risk for this type of cancer in DES Daughters as they age

DES and Cancer: the Never Ending Story

Diethylstilbestrol DES clear cell adenocarcinoma CCA vaginal cancer41 years ago, a connection between DES exposure and cancer in DES daughters was established.  Cases of Clear Cell Adenocarcinoma (CCA) of the vagina were diagnosed in an age group never before found to develop it. At the time the peak incidence of CCA in DES Daughters was in the late teens and early 20s. Most young women with CCA of the vagina have a history of prenatal exposure to diethylstilbestrol (DES). DES daughters were told by physicians that the risk was low when you reach your 30s and you can still read today on some websites that “if a DES daughter has not developed this cancer by age 30, she will not develop it”.

But today, DES daughters cancer fears are confirmed and justified as the findings and conclusions of a new report by CDC researchers suggest an elevated risk for this vaginal/cervical cancer in DES Daughters as they age.

When researchers first linked prenatal DES exposure to vaginal / cervical cancer in a small group of women, soon after, the Food and Drug Administration (FDA) notified physicians throughout the U.S.A. that DES should not be prescribed to pregnant women (note that it wasn’t banned!). In Europe, the drug continued to be prescribed to pregnant women until 1978. So even though this report says “elevated risk among women born between 1947 and 1971 in the United States”, it should read “among all women born between 1947 and 1978 in countries where DES was prescribed”. In the United States alone it is estimated that five to 10 million people were exposed to DES between 1938 and 1971.

When will this stop?  The statement “The more I learn the less I know” really seems to apply to the DES tragedy. As we learn more about the devastating health effects of diethylstibestrol, we begin to become more aware of the limits of our knowledge regarding the long term effects not only for DES daughters but also DES sons and the DES 3rd generation (children of DES daughters and sons). DES truly is a never ending story!

Wherever you are stay safe and remind your GP that DES daughters need yearly Pap test and pelvic exam as well as regular health screening and adequate care!

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New England Journal of Medicine Report

Diethylstilbestrol in utero exposure and cancers risk, 2011

From Maryland – Exposure to Diethylstilbestrol in the womb raises a woman’s risk of many cancers, according to a report published in the New England Journal of Medicine. Researchers studied over 6500 women, 4600 of whom were exposed to DES in the womb. Results showed that this exposure significantly increased risk of many cancers and fertility problems, including a 40x increased risk of clear-cell adenocarcinoma, 8x increased risk of neonatal death, 2.4x increased risk of infertility and a 1.8x increased risk of breast cancer.

Video from Insidermedicine In 60.

Watch our compilation of DES Videos in English on YouTube via the Diethylstilboestrol Channel.

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Beating Cancer One Lap at a Time

DES Daughter Susan Helmrich is one of the best swimmers in the world in her age group

Susan Helmrich is one of the best swimmers in the world in her age group. She’s also a three-time cancer survivor and a victim of one of the greatest drug tragedies in history. With luck, determination, great medical care, the support of family and friends and the benefits of the sport of swimming, Susan has fought to escape the deadly legacy of a supposed wonder drug turned nightmare.

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SlideShow DES Adverts

Back in the 1950’s and 1960’s, doctors were the target for most drug advertising campaigns including DES

DES Adverts Information

desPLEX

 

Back in the 1950’s and 1960’s, doctors were the target for most drug advertising campaigns including DES as shows this Flickr album.

Drug companies supplied hundreds of doctors with samples to give to their female patients, thus creating a market for the drug (in the case of diethylstilbestrol even before it was approved by the FDA).

Somehow DES set the template of “How To” market a dangerous drug to women. In 1948, diethylstilbestrol was advertised as the “Wonder Drug” recommended for all pregnancies. The face of a cherubic infant grinned up from the pages of medical journals next to the caption: “Really? Yes, desPLEX to prevent abortion, miscarriage and premature labor…bigger and stronger babies“.

As early as 1953, research revealed that DES did not work – that DES actually brought about higher rates of premature birth and infant mortality – yet DES continued to be prescribed to pregnant women for decades mainly because pharmaceutical companies continued to heavily promote DES use to doctors and most doctors relied on the drug companies and their sales representatives for information.

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2012 DES UK Media Coverage

Thousands of women could be at risk from silent Thalidomide

Since Sunday 22nd January 2012, there has been an unprecedented flurry of media attention on DES related health issues in the United Kingdom. This comes after two journalists – Sarah Morrison and Jaymi McCann – thoroughly investigated DES issues in the UK and published an exclusive DES report in the Independent on Sunday: “Thousands of women could be at risk from silent Thalidomide. Very quickly ripple effects started and the story spread not only throughout the country but as far as the U.S. and Australia. Many newspapers and websites caught up on the story thus increasing DES awareness locally and nationally and forcing UK health websites to update their DES information.

“Silent Thalidomide” the Secret Killer – Ten of thousands of British women in pregnancy drug scare – Exclusive Report

Independent on Sunday – Jan 22, 2012 : “Thousands of women could be at risk from silent Thalidomide”

Daily Mail – Jan 22, 2012 : ‘Silent Thalidomide’: Thousands of mothers and their daughters at risk of cancer from anti-miscarriage drugs they took decades ago

Lifestyle AOl –  Jan 22, 2012 : “Anti-miscarriage drug could cause cancer in daughters of women who took it decades ago”

Yorkshire Post – Jan 23, 2012 : “Call for compensation over pregnancy drug “

Press Association ( UKPA) – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters'”

Once the story was published by the UK Press Association it started to spread all over the country, here are a few websites where it was re-published:

London Evening Standard – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters'”

Yahoo News – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Topix, Local News Bristol – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

The Bucks Herald – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Fenland Citizen – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Crawley and Horley Observer – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Pendle Today – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Harvill Echo – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Boston Standard – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Buckingham Today – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Leigh Reporter – Jan 22, 2012: “Lawyer hunts for UK ‘DES daughters”

Halifax Courier, the Voice of Calderdale – Jan 22, 2012: “Lawyer hunts for UK ‘DES daughters”

Selby Times – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Peterborough Today – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Newmarket Journal – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Scaborough Evening News – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Hastings & St Leonards Observer – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Hemel Today – Jan 27, 2012 : “Lawyer hunts for UK ‘DES daughters”

Isle of Man Examiner – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Sussex Express – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

IC Newcastle – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Diss Express – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

News Post Leader – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Guardian – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Fleetwood Weekly News – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Suffolk Free Press – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Thame Gazette – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

Pocklington Post – Jan 22, 2012 : “Lawyer hunts for UK ‘DES daughters”

………………………. The list continues endlessly to cover 16 Google Search Pages. Enter “Lawyer hunts for UK ‘DES daughters” in your Google Search Box for the full list. Jaymi McCann’s report in the Independent on Sunday truly created ripples, waves, or should I say rather a tsunami in the UK Press.

I am thrilled that the work my husband and I have been doing over the past year or so to raise DES awareness in the UK via our Social Media networks is paying off.  As far as I know when Jaymi McCann stumbled upon my “Journal of a DES daughter” she knew little about DES but my story and the information featured in my blog was enough to spark her interest. I can’t thank her enough for the extraordinary work she and Sarah Morrison have done to pull this excellent report together. I am grateful for the opportunity they’ve given me to share my DES story to such a large audience and for the repercussions the report will have for DES daughters and hopefully also DES sons and DES grandchildren in the UK . Now the UK government and the NHS must react, launch an national awareness campaign and ensure DES victims in the UK receive appropriate care and monitoring. Let’s keep the pressure on …

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SlideShow DES Research

About chemicals that, at certain doses, can interfere with the endocrine (or hormone) system in mammals

DES and EDCs Research

The DES Mouse at 6 Months of Age

 

The FlickrDES Researchphoto set features a selection of graphs, stats and the 2011 AFSSAPS DES survey report from France about the adverse effects of Diethylstilbestrol, the synthetic oestrogen prescribed to millions of pregnant women around the world decades ago in the mistaken belief that it would reduce the risk of complications during pregnancy.

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The DES Generations Concern

Diethylstilbestrol DES has consequences for those who took it, their children and maybe their grandchildren

Meet Caitlin McCarthy, a multi-award winning writer and DES Daughter. Diethylstilbestrol DES has consequences for those who took it, their children and maybe their grandchildren.

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SlideShow DES Media

A selection of press cuttings from around the world about the adverse effects of Diethylstilbestrol

DES Press Releases

DES Exclusive Report, UK - Independent on Sunday Front Cover

 

The FlickrDES Press Releasesphoto set features a selection of press cuttings from around the world in English and French about the adverse effects of Diethylstilbestrol, the synthetic oestrogen prescribed to millions of pregnant women around the world decades ago in the mistaken belief that it would reduce the risk of complications during pregnancy.

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DES and Breast Cancer

A breast cancer survivor, Jackie, reports on her DES journey

Jackie White is one of 53 women who is bringing the DES Breast Cancer lawsuit in Boston against the maker of the drug DES (diethylstilbestrol) prescribed to millions of women decades ago.

According to a large study, DES, the anti-miscarriage drug used in the USA until 1971 but also used in Australia and many European countries well after 1971, has been linked to health problems — including breast cancer, infertility, difficult pregnancies and early menopause — in the daughters and the granddaughters of women who took it.

The study suggests that one in 50 DES daughters had the chance of developing breast cancer due to their DES exposure.
Read more about DES and breast cancer risks.

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The DES Paper 40th Anniversary – Dr Arthur Herbst

The University of Chicago, 17 May 2011

Commemorating Arthur L Herbst and the 40th Anniversary of His Landmark DES Paper.

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