Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol
” … scientists at the National Institute of Environmental Health Sciences report that they have observed an increase in cancers, including cancer of the uterus, in female mice whose mothers were exposed to DES in utero — while in the uterus … ”
1998 Study Abstract
Prenatal exposure to diethylstilbestrol (DES) has been associated with the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia, in experimental animals and humans. Experimental animal studies with chemical carcinogens have raised the possibility that adverse effects of DES may be transmitted to succeeding generations. To evaluate this possibility and to determine if there is a sensitive window of developmental exposure, outbred CD-1 mice were treated with DES during three stages of development: group 1 was treated on days 9-16 of gestation (2.5, 5 or 10 microg/kg maternal body wt), the time of major organogenesis; group II was treated once on day 18 of gestation (1000 microg/kg maternal body wt) just prior to birth; group III was treated on days 1-5 of neonatal life (0.002 microg/pup/day). Female mice (F1) in each group were raised to sexual maturity and bred to control males. As previously reported, fertility of the F1 DES-exposed females was decreased in all groups. Female offspring (DES lineage or F2) from these matings were raised to maturity and housed with control males for 20 weeks. The fertility of these DES lineage female mice was not affected by DES exposure of their ‘grandmothers’. DES lineage mice were killed at 17-19 and 22-24 months of age. An increased incidence of malignant reproductive tract tumors, including uterine adenocarcinoma, was seen in DES lineage mice but not in corresponding controls; the range and prevalence of tumors increased with age. Because uterine adenocarcinomas were seen in all three DES groups, all developmental exposure periods were considered susceptible to the adverse effects of DES. These data suggest that the reduced fertility observed in the DES F1 female mice was not transmitted to their descendants; however, increased susceptibility to tumor formation is apparently transmitted to subsequent generations.
Read ‘DES Daughters’ Had Increased Rates Of Cancer; An Animal Study Shows ‘DES Granddaughters’ May Too, qajyjuvoma, Medical News, June 26, 2012.
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Parker Waichman LLP is one of the preeminent personal injury law firms in the US. If you were diagnosed with breast cancer, and are a DES Mother or a DES Daughter, you may be entitled to receive compensation for medical bills, lost wages, pain and suffering, and other damages.
In summary, by its actions and inactions, the TGA has stymied the availability of data to the Department of Health and Ageing in relation to the magnitude of the DES problem in Australia
Great disappointment from Down Under! Australian Senate PIP Inquiry rejects DES story’s correlation to PIP breast implant scandal … This is tragic for PIP recipients and all other victims of drug/medical device disasters. Kudos to DES Activist Carol Devine for making a submission about the Therapeutic Goods Administration’s (TGA) mismanagement of the DES drug disaster and how this correlates to the TGA’s current handling of the PIP scandal. It’s so disheartening for DES Activists all over the world … What will it take for the DES story to be heard and its lessons to be learned …?????