Mice Study shows DES GrandDaughters may have increased Rates of Cancer

Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol

Mice Study shows DES Granddaughters’ may have increased Rates of Cancer” … scientists at the National Institute of Environmental Health Sciences report that they have observed an increase in cancers, including cancer of the uterus, in female mice whose mothers were exposed to DES in utero — while in the uterus … ”

1998 Study Abstract

 

Prenatal exposure to diethylstilbestrol (DES) has been associated with the subsequent development of reproductive tract abnormalities, including poor reproductive outcome and neoplasia, in experimental animals and humans. Experimental animal studies with chemical carcinogens have raised the possibility that adverse effects of DES may be transmitted to succeeding generations. To evaluate this possibility and to determine if there is a sensitive window of developmental exposure, outbred CD-1 mice were treated with DES during three stages of development: group 1 was treated on days 9-16 of gestation (2.5, 5 or 10 microg/kg maternal body wt), the time of major organogenesis; group II was treated once on day 18 of gestation (1000 microg/kg maternal body wt) just prior to birth; group III was treated on days 1-5 of neonatal life (0.002 microg/pup/day). Female mice (F1) in each group were raised to sexual maturity and bred to control males. As previously reported, fertility of the F1 DES-exposed females was decreased in all groups. Female offspring (DES lineage or F2) from these matings were raised to maturity and housed with control males for 20 weeks. The fertility of these DES lineage female mice was not affected by DES exposure of their ‘grandmothers’. DES lineage mice were killed at 17-19 and 22-24 months of age. An increased incidence of malignant reproductive tract tumors, including uterine adenocarcinoma, was seen in DES lineage mice but not in corresponding controls; the range and prevalence of tumors increased with age. Because uterine adenocarcinomas were seen in all three DES groups, all developmental exposure periods were considered susceptible to the adverse effects of DES. These data suggest that the reduced fertility observed in the DES F1 female mice was not transmitted to their descendants; however, increased susceptibility to tumor formation is apparently transmitted to subsequent generations.
Read ‘DES Daughters’ Had Increased Rates Of Cancer; An Animal Study Shows ‘DES Granddaughters’ May Too, qajyjuvoma, Medical News, June 26, 2012.

More DES DiEthylStilbestrol Resources

Double Standard: Women must typically Work Harder to Lose Weight

Several Factors Make Weight Loss for Men Easier

Women Must Typically Work Harder to Lose Weight

 

The gender gap is a phrase usually used to describe disparities in income between men and women, but it may very well apply to weight loss as well.

Read weight loss for women by Dr. Mercola via J. Ruth Kelly

Eli Lilly lawsuit – The Melnick sisters interview – Boston DES Breast Cancer trial

This is a drug that was never adequately tested and never adequately warned said Aaron Levine, a lawyer for the Melnick sisters and the other women who have sued in Boston.

The Melnick sisters

  • Read Sisters take Eli Lilly to court over their breast cancer on IndyStar.com
  • Read Diethylstilbestrol Lawsuit: Melnick Sisters Sue Eli Lilly And Co., Producer Of DES Pregnancy Drug, After Breast Cancer Diagnoses on The Huffington Post
  • Read ‘DES Daughters’ to sue Drug Company over link between Mother’s Pregnancy Drug and Breast Cancer on BlissTree.com
  • Read Trial set to begin in Boston over pregnancy on boston.com and on drugwcvb.com

Boston DES Breast Cancer Trial 2013 January 08th

Prothèses PIP : les autorités savaient

En octobre 2009, 14 ruptures PIP sont constatées

Prothèses PIP : les autorités savaientL’Agence de sécurité du médicament collectionne les ratés: Mediator, di-Antalvic, cérivastatine, distilbène… tous ont tardé à être retirés du marché malgré les signaux envoyés.

Lisez: Prothèses PIP : les autorités savaient,
Le Petit Bleu – santé, 07/01/2012.

What are your thoughts on the HPV Vaccine?

Young Women Are Not Completing the HPV Vaccine Regimen

vaccination image
Young Women Are Not Completing the HPV Vaccine Regimen

Read post Young Women Are Not Completing the HPV Vaccine Regimen

and the update New Evidence Demolishes Claims of Safety and Effectiveness of HPV Vaccine

By the way, did you take the Gardasil Cervarix HPV Vaccine Survey?

New Evidence Demolishes Claims of Safety and Effectiveness of HPV Vaccine

The HPV Vaccine Risks You’re Not Being Told About

New Evidence Demolishes Claims of Safety and Effectiveness of HPV Vaccine

There are currently two HPV vaccines on the market, but if there was any regard for sound scientific evidence, neither would be promoted as heavily as they are.

  • Review of HPV Trials Conclude Effectiveness is Still Completely Unproven
  • Media Reports on Merck Study, But Ignores Canadian Review
  • The HPV Vaccine Risks You’re Not Being Told About
  • Large-Scale Study Shows HPV Vaccine is Ineffective and Increases Rate of Carcinogeic HPV Types in Vaccinated Women
  • Talk to Your Kids about HPV and Gardasil
  • Jerry Brown Signs Bill Requiring Signatures for Those Opting Out of Vaccinations
  • Why We Must Protect Vaccine Exemptions

Read New Evidence Demolishes Claims of Safety and Effectiveness of HPV Vaccine

DES and Breast Cancer

Parker Waichman LLP is one of the preeminent personal injury law firms in the U.S.

DES and Breast CancerLegal Help for Victims

Parker Waichman LLP is one of the preeminent personal injury law firms in the US.  If you were diagnosed with breast cancer, and are a DES Mother or a DES Daughter, you may be entitled to receive compensation for medical bills, lost wages, pain and suffering, and other damages.

More info on DES Breast Cancer website.

More DES DiEthylStilbestrol Resources

PIP Inquiry rejects DES Story

In summary, by its actions and inactions, the TGA has stymied the availability of data to the Department of Health and Ageing in relation to the magnitude of the DES problem in Australia

PIP Inquiry Rejects DES StoryGreat disappointment from Down Under! Australian Senate PIP Inquiry rejects DES story’s correlation to PIP breast implant scandal … This is tragic for PIP recipients and all other victims of drug/medical device disasters. Kudos to DES Activist Carol Devine for making a submission about the Therapeutic Goods Administration’s (TGA) mismanagement of the DES drug disaster and how this correlates to the TGA’s current handling of the PIP scandal. It’s so disheartening for DES Activists all over the world … What will it take for the DES story to be heard and its lessons to be learned …?????

Read PIP Inquiry Rejects DES Story.

More DES DiEthylStilbestrol Resources

Hormone Replacement Therapy: The Wonder Drug for the ’90s?

The Advantages and the Disadvantages of HRT

HRT The Wonder Drug for the ’90s
Proceed with extra caution if you have been exposed to DES

What are your views about HRT?

Do you think the benefits of Hormone Replacement Therapy during menopause are worth the risks, known and unknown?
Is the treatment safe for DES-exposed women?

Read HRT The Wonder Drug for the ’90s
by Isabelle Trépanier and Marie Cocking, DES Action Canada

All our posts about Estrogen – HRT – Menopause.

Breast Milk Secrets that the FDA doesn’t want You to Know

Do The Infant Formulas Have The Right Type Of Fats?

Breast Milk Secrets that the FDA doesn’t want You to KnowNot DES related but a fascinating article! Formula milk, synthetic oestrogens (like DES), you name it, nature can’t be replicated and so true health can’t be mimicked! …

Read Breast Milk Secrets that the FDA doesn’t want You to Know