DES Follow-up Study Summary
In this study we evaluated whether women who were exposed in utero to Diethylstilbestrol (DES) follow the recommendations for cervical screening and general physical examinations.
DES-exposed (3140) and unexposed women (826) from the Houston, Boston, Rochester and Los Angeles sites reported on the 1994 questionnaire how frequently over the preceding five years (1990-1994) they had Papanicolau (Pap) smears and general physical examinations.
The study found that DES-exposed women exceeded the recommended frequency of Pap smear screenings compared to unexposed women. The DES exposed women also exceeded the annual recommendations for physical examinations among women without a history of chronic disease when compared to unexposed women. Whereas most DES-exposed women are receiving cervical cancer screening at recommended intervals, a third are not having these annual Pap smear examinations.
2008 Study Abstract
To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women.
Materials and Methods:
1994 Diethylstilbestrol Adenosis cohort data are used to assess the degree of recommended compliance of cervical screenings found in 3,140 DES-exposed and 826 unexposed women. Participants were enrolled at 4 sites: Houston, Boston, Rochester, and Los Angeles. Logistic regression modeling was used to analyze mailed questionnaire data, which included reported frequency over the preceding 5 years (1990-1994) of Papanicolaou smears and general physical examinations.
Diethylstilbestrol-exposed women exceeded the recommended frequency of Papanicolaou smear screenings [adjusted odds ratio (aOR) = 2.15, 95% CI (confidence interval) = 1.60-2.88] compared to the unexposed. This association held among those without a history of cervical intraepithelial neoplasia (aOR = 1.88, 95% CI = 1.35-2.62). Diethylstilbestrol-exposed women exceeded annual recommendations for physical examinations (aOR = 2.27, 95% CI = 1.16-4.43) among women without a history of chronic disease when compared to unexposed women.
Most DES-exposed women are receiving cervical cancer screening at least at recommended intervals, but one third of the women are not receiving annual Papanicolaou smear examinations.
- Cervical screening and general physical examination behaviors of women exposed in utero to diethylstilbestrol, NCBI, PMID: 18369304, 2008 Apr;12(2):111-7. doi: 10.1097/LGT.0b013e31815ae980.
- NCI, DES Follow-up Study Published Papers.
- Screening for DES Daughters – Exposed to DES? Get a Pap Smear!
- Cervical Cancer: Screening Pap Smears tied to higher Cure Rate, study showed
- Are you a probable DES Daughter? See this Chart and establish how much Risk you face!
More DES DiEthylStilbestrol Resources
- DES studies on cancers and screening.
- DES studies on epigenetics and transgenerational effects.
- DES studies on fertility and pregnancy.
- DES studies on gender identity and psychological health.
- DES studies on in-utero exposure to DES and side-effects.
- DES studies on the genital tract.
- Papers on DES lawsuits.
- DES videos and posts tagged DES, the DES-exposed, DES victims.