Endocrine-disrupting Chemicals impact on Obesity for those exposed in-Utero

Developmental exposure to estrogenic compounds and obesity

Chemicals May Play Role in Rise in ObesityA 2005 NIEHS Study where DES appears to permanently disrupt the hormonal mechanisms regulating body weight…

… ” Exposure to tributyltin is increasing the number of fat cells, so the individual will get fatter faster as these cells produce more of the hormones that say ‘feed me ” … ” Once these genetic changes happen in utero, they are irreversible and with the individual for life ” …


Taken together, our data support the idea that brief exposure to low levels of environmental estrogens early in life increases body weight as the mice age. Whether our results can be extrapolated to humans, as in the reproductive abnormalities from the DES mouse model, remains to be determined, but this is a fruitful area for further research. In addition, the use of this mouse model to study mechanisms involved in altered weight homeostasis (direct and/or endocrine feedback loops, e.g., ghrelin, leptin) by environmental endocrine disrupting chemicals is an important basic research area that may shed light on the future prevention and treatment of obesity.

DES and Obesity

More DES DiEthylStilbestrol Resources

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