Endocrine Disruption of the Neuro-immune Interface

By the Collaborative on Health and the Environment

Dr. Jamie DeWitt describes scenarios where endocrine disrupting chemicals can alter brain development by changing signals to the immune cells that can mediate development of sex specificity in the brain.

Building on the January 8, 2014 teleconference featuring Dr. Rodney Dietert  on how the developing immune system is a target for endocrine disrupting chemicals, Dr. Jamie DeWitt discussed how certain cells of the immune system may mediate endocrine signals to direct aspects of brain development. She also described scenarios where endocrine disrupting chemicals can alter brain development by changing signals to the immune cells that can mediate development of sex specificity in the brain.

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Additional resources of interest:
  • Suppression of Humoral Immunity by Perfluorooctanoic Acid is Independent of Elevated Serum Corticosterone Concentration in MicePDF
  • Current Status of Developmental Immunotoxicity: Early-Life Patterns and TestingPDF
  • Breaking Patterns of Environmentally Influenced Disease for Health Risk Reduction: Immune PerspectivesPDF
  • Bisphenol A: Developmental Toxicity from Early Prenatal ExposurePDF

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