Health risks and effects of prenatal exposure to diethylstilbestrol

The Journal of family practice, 1983

DiEthylStilbestrol usage review buttress the need for adequate and rigorous research into the use of drugs in pregnancy and ensure that they do more good than harm before being introduced for consumption.
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1983 Study Abstract

Patients exposed prenatally to diethylstilbestrol (DES) have been shown to have a number of significant health risks that may be considered in the evaluation of this population. Neoplastic lesions of the cervix and vagina have been observed in a few patients. Increased prevalence of squamous intraepithelial neoplasms has been reported by several large clinical centers, and a recent observation of ovarian neoplasms has been reported. The significance of these observations remains to be substantiated. Anatomic deformities of the cervix, vagina, uterus, and fallopian tubes have been associated with increased pregnancy loss or infertility. The epithelial abnormalities of adenosis and cervical erosion essentially hallmark prenatal exposure to diethylstilbestrol. These changes are in themselves not malignant or premalignant and rarely warrant therapy.

Sources and more information
  • Health risks and effects of prenatal exposure to diethylstilbestrol, The Journal of family practice, NCBI PMID: 6848637, 1983 Jan;16(1):51-4.
More DES DiEthylStilbestrol Resources

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