Increase in Birth Defects with Topiramate and Valproate Drugs

14-fold increase in birth defects in those taking topiramate in pregnancy

UK Pregnancy Study Finds Slight Increase in Birth Defects with Topiramate
There was a 14-fold increase in birth defects in those taking topiramate with other antiseizure medications

Researchers in the United Kingdom reported in a study – Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register – an increase in birth defects among children born to mothers taking the antiseizure medications  valproate and/or topiramate (Topomax) – also widely prescribed in the US for migraine.

Read UK Pregnancy Study Finds Slight Increase in Birth Defects with Topiramate, Neurology Today, 2009.

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