Low-dose exposures to chemical mixtures in the environment and cancer risk

Low-Dose Exposures to Chemical Mixtures in the Environment linked to Human Cancer: Cause and Prevention

The relative contribution of the environment, genetic susceptibility and DNA replication errors to cancer causation has been a longstanding area of investigation in the fields of molecular epidemiology of cancer and carcinogenesis.

Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This risk may be overlooked by current regulatory practices and needs to be vigorously investigated.

Carcinogenesis published a series of reviews on the carcinogenic potential of exposure to low doses and mixtures of chemicals.

  • Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression, Suppl_1/S2.full, September 19, 2014.
  • Disruptive chemicals, senescence and immortality, Suppl_1/S19.full, August 5, 2014.
  • The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling, Suppl_1/S38.full, December 15, 2014.
  • Causes of genome instability: the effect of low dose chemical exposures in modern society, Suppl_1/S61.full, December 11, 2014.
  • Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death, Suppl_1/S89.full, February 3, 2015.
  • Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions, Suppl_1/S111.full, January 19, 2015.
  • The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis, Suppl_1/S128.full, November 19, 2014.
  • The effect of environmental chemicals on the tumor microenvironment, Suppl_1/S160.full, November 28, 2014.
  • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis, Suppl_1/S184.full, December 15, 2014.
  • Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?, Suppl_1/S203.full, February 24, 2015.
  • Environmental immune disruptors, inflammation and cancer risk, Suppl_1/S232.full, January 14, 2015.
  • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead, Suppl_1/S254.full, January 31, 2015.

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