A technique that uses focused ultrasound under magnetic resonance (MR) guidance to heat and destroy tumors may offer a safe and effective treatment for breast cancer, according to research being presented this Wednesday at the annual meeting of the Radiological Society of North America (RSNA).
PURPOSE:
To assess safety and feasibility of non-invasive high intensity 3T MR guided focused Ultrasound (MRgFUS) ablation of biopsy-proven invasive ductal breast cancer (IDC) (stage T1 M0 N0) before surgical resection and sentinel lymph node biopsy.
METHOD AND MATERIALS:
Our retrospective study included 12 patients with unifocal biopsy-proven IDC, scheduled and consented to lumpectomy and sentinel lymph node biopsy. We use 3T MRI exam (Discovery 750, GE; Gd-BOPTA, Bracco) to confirm presence and treatable location of enhancing lesion (less than 2 cm). Patient underwent day-surgery single session MRgFUS treatment using ExAblate 2100 system (InSightec), under IRB approval. Post-surgery pathology evaluation test the efficacy of the treatment.
RESULTS:
No significant complications were observed in all subjects during or immediately after the procedure. In 10 patients, multiparametric MRI no shows enhancement at breast treatment area. Post-surgery histological evaluation confirmed the absence of residual neoplastic foci in necrotic tissue area with at least 5 mm margins of normal breast tissue in all 10 patients. In 2 cases treatment failed due to transducer malfunction, and pathologist observed 15% of residual tumor. Results demonstrate excellent agreement between pathology and post-treatment MRI.
CONCLUSION:
MRgFUS is a promise treatment to determines focal and noninvasive excision of unifocal breast cancer, according to histopathology findings.
CLINICAL RELEVANCE/APPLICATION:
MRgFUS is an innovative incisionless technique to obtained reliable ablation of invasive breast cancer and successful clinical outcome.
Read MR-guided Ultrasound Offers Noninvasive Treatment for Breast Cancer, RSNA Press Release, 4 Dec 2013
Sources: Clinical Experience in Noninvasive Treatment of Focal Breast Cancer with Magnetic Resonance Guided High Intensity
Focused Ultrasound (MRgFUS), RSNA, 4 Dec 2013
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Alain
merci Alain
Thanks for the info Dom
Oncle Gerrit
thanks, this looks good so far